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Methotrexate Blog

Lower Doses of Rheumatoid Arthritis Drugs May Work for Some

Posted 5 Nov 2014 by Drugs.com

WEDNESDAY, Nov. 5, 2014 – Some people in the early stages of rheumatoid arthritis may be able to safely lower their medication doses once their symptoms are well under control, a new study suggests. In a clinical trial, British researchers found that many patients were able to remain in remission for months after their doctors lowered their doses of the drugs methotrexate and Enbrel (etanercept). What's more, some continued to do well when they were taken off the drugs altogether, the researchers said in the Nov. 6 issue of the New England Journal of Medicine. The findings suggest it's "reasonable" to lower, or even stop, certain patients' medication doses, wrote the researchers, led by Dr. Paul Emery of the University of Leeds. But experts not involved in the study stressed that there are some big unknowns. For one, it's not clear which patients would likely do well if their drug ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Enbrel, Etanercept, Methotrexate LPF Sodium, Trexall, Rheumatrex Dose Pack, Rasuvo, Otrexup, Folex PFS

Medicines Are Biggest Culprit in Fatal Allergic Reactions: Study

Posted 10 Oct 2014 by Drugs.com

THURSDAY, Oct. 9, 2014 – Although food allergies have garnered a lot of attention lately, a new study reports that medications are actually the biggest cause of sudden deaths related to allergy. Over a little more than a decade, nearly 60 percent of the allergy-related deaths were caused by medications, while less than 7 percent were caused by food allergies, the study found. "Medications can be dangerous," said study researcher Dr. Elina Jerschow, director of the Drug Allergy Center at Montefiore Medical Center and assistant professor of medicine at Albert Einstein College of Medicine, in New York City. While research from other countries has reported medications as a major culprit in anaphylaxis-related deaths, Jerschow said, the problem has been less defined in the United States. One reason is that there is no national registry for anaphylaxis deaths, she said. The study was ... Read more

Related support groups: Provera, Amoxicillin, Doxycycline, Depo-Provera, Methotrexate, Penicillin, Bactrim, Cephalexin, Clindamycin, Metronidazole, Azithromycin, Lupron, Cipro, Accutane, Ciprofloxacin, Levaquin, Augmentin, Flagyl, Zithromax, Keflex

FDA Approves Rasuvo (methotrexate) Injection

Posted 14 Jul 2014 by Drugs.com

Chicago, IL, July 14, 2014 – Medac Pharma, Inc., a privately held pharmaceutical company focused on the development of new molecules and improving the effectiveness of existing medicines, announced that the U.S. Food and Drug Administration (FDA) has approved Rasuvo, a subcutaneous injectable methotrexate (MTX) therapy delivered in an auto-injector for rheumatoid arthritis (RA), polyarticular-course juvenile idiopathic arthritis (pJIA) and psoriasis. Rasuvo will be available in 10 dosage strengths, ranging from 7.5 mg to 30 mg in 2.5 mg increments and will be launched in the U.S. The company concurrently announced that the U.S. District Court for the District of Delaware has denied a motion for a preliminary injunction filed by Antares Pharma, Inc. “We’re delighted to have secured approval for our lead product, Rasuvo, and look forward to introducing this much-needed therapy to the ma ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Psoriasis, Juvenile Idiopathic Arthritis

Otrexup (Methotrexate) Injection Approved By FDA

Posted 15 Oct 2013 by Drugs.com

EWING, N.J., October 14, 2013 — Antares Pharma, Inc. today announced the approval of Otrexup (methotrexate) injection by the U.S. Food and Drug Administration (FDA). Otrexup is the first FDA approved subcutaneous (SC) methotrexate (MTX) for once weekly self-administration with an easy-to-use, single dose, disposable auto injector. Otrexup is indicated for adults with severe active rheumatoid arthritis (RA) who have had an insufficient therapeutic response to or are intolerant of an adequate trial of first line therapy including full dose non-steroidal anti-inflammatory agents (NSAIDs), or children with active polyarticular juvenile idiopathic arthritis (pJIA). The FDA also approved adult use of Otrexup for symptomatic control of severe recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy. In 2012, approximately six million prescriptions were w ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Psoriasis, Juvenile Rheumatoid Arthritis, Juvenile Idiopathic Arthritis

Kidney Damage a Risk of Some Childhood Cancer Treatments, Finds Study

Posted 24 Sep 2013 by Drugs.com

TUESDAY, Sept. 24 – Some adult survivors of childhood cancer are at increased risk for kidney problems, a new study says. The study included more than 1,100 adults, aged 18 and older, who were followed for five to 42 years after being diagnosed and treated for childhood cancer. The researchers examined the long-term effects of kidney-damaging treatments, including the chemotherapy drugs ifosfamide, cisplatin, carboplatin, high-dose methotrexate and high-dose cyclophosphamide; radiation therapy to the kidney region; and partial or complete surgical removal of the kidney (nephrectomy). Compared with patients who did not receive kidney-damaging treatments, those who were treated with ifosfamide or cisplatin and those who underwent nephrectomy had poorer kidney function, which persisted throughout the follow-up period. The researchers also found that patients treated with high doses of ... Read more

Related support groups: Cancer, Methotrexate, Renal Failure, Carboplatin, Cytoxan, Cisplatin, Cyclophosphamide, Platinol, Trexall, Methotrexate LPF Sodium, Ifosfamide, Cytoxan Lyophilized, Folex PFS, Paraplatin, Carboplatin Novaplus, Rheumatrex Dose Pack, Ifex, Neosar, Platinol-AQ

Expensive or Not, Rheumatoid Arthritis Drugs Have Similar Effect: Study

Posted 1 Jul 2013 by Drugs.com

MONDAY, July 1 – Treatment with a pricey biological drug was no better than cheaper, conventional therapy in terms of reducing time off from work for people with rheumatoid arthritis, a new study finds. Swedish researchers assessed lost work days among rheumatoid arthritis patients who had not responded to initial treatment with a standard medication, methotrexate. The group of 204 patients were randomly given either the biological drug infliximab (Remicade) or conventional combination therapy with the non-biologics sulfasalazine plus hydroxychloroquine. At the start of the study, the average amount of lost work time was 17 days per month for all patients. During the 21-month study, the patients receiving conventional therapy lost about six fewer days of work per month, compared with about five fewer days for those taking Remicade – not a significant difference. Regardless of the ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Remicade, Plaquenil, Hydroxychloroquine, Sulfasalazine, Infliximab, Azulfidine, Sulfazine, Trexall, Methotrexate LPF Sodium, Plaquenil Sulfate, Folex PFS, Quineprox, Rheumatrex Dose Pack, Azulfidine EN-tabs

Rheumatoid Arthritis Treatment May Not Work As Well for Heavier Patients

Posted 18 Jun 2013 by Drugs.com

TUESDAY, June 18 – Overweight and obese people with rheumatoid arthritis are less likely to go into remission in the early stages of the disease and require much more drug treatment than people with normal weight, according to a new study. The study included nearly 350 people with early rheumatoid arthritis (RA) who underwent a treatment meant to achieve remission of their disease. The strategy included strict follow-up visits, as well as treatment with steroids and the drug methotrexate, combined with anti-tumor necrosis factor (anti-TNF) therapy if a good response didn't occur. Anti-TNF drugs are used to reduce inflammation in a variety of conditions. At six and 12 months of follow-up, overweight and obese patients had lower rates of remission. After 12 months, a higher percentage of overweight and obese patients were still on anti-TNF therapy, compared to normal-weight patients. The ... Read more

Related support groups: Obesity, Rheumatoid Arthritis, Methotrexate, Humira, Enbrel, Remicade, Cimzia, Simponi, Infliximab, Etanercept, Adalimumab, Golimumab, Trexall, Methotrexate LPF Sodium, Folex PFS, Certolizumab, Rheumatrex Dose Pack

Standard Rheumatoid Arthritis Therapy as Good as Costlier Newcomer: Study

Posted 12 Jun 2013 by Drugs.com

TUESDAY, June 11 – Newer, costlier treatment for rheumatoid arthritis appears no better than an older, less-expensive regimen for people who don't respond to the first-line drug methotrexate, a new study suggests. "Newer isn't always better," said researcher Dr. Ted Mikuls, an associate professor in the rheumatology division at the University of Nebraska Medical Center, in Omaha. "Some of the older medications can be effective." Rheumatoid arthritis causes inflammation in the joints, resulting in swelling, stiffness, pain and reduced joint function. It can also affect other parts of the body. "We compared two different ways of treating rheumatoid arthritis – one that included a new biologic [medication] with an older, more conventional oral medication," Mikuls explained. "We basically showed that at the end of the day patients, regardless of what they got, looked very similar in terms ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Enbrel, Plaquenil, Hydroxychloroquine, Sulfasalazine, Azulfidine, Sulfazine, Etanercept, Trexall, Methotrexate LPF Sodium, Folex PFS, Quineprox, Plaquenil Sulfate, Rheumatrex Dose Pack, Azulfidine EN-tabs

FDA Medwatch Alert: Methotrexate Sodium, USP Injectable Vials by Sandoz US: Recall - Particulate Matter In Vials

Posted 22 May 2013 by Drugs.com

ISSUE: Sandoz is conducting a voluntary nationwide recall to the hospital/user level of two lots of its Methotrexate Sodium, USP, 25 mg/mL, 40 mL vial injectable product in the US, due to the discovery of particulate matter in vials during routine quality examination of retention samples at the manufacturer. Parenteral injection of drug from the affected lots can lead to microembolisation in areas where the particles lodge. Clinical symptoms are not to be expected from these microemboli and Sandoz is not aware of any reports of related adverse events. BACKGROUND: Methotrexate is an antimetabolite used in the treatment of neoplastic diseases, severe psoriasis, and rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis. The lot numbers and expiration dates of the two recalled lots are: CL0996 (expiration date 12/2013) and CJ4948 (expiration date 05/2013). These lots ... Read more

Related support groups: Cancer, Methotrexate, Trexall, Methotrexate LPF Sodium, Folex PFS, Rheumatrex Dose Pack

Cancer Chemotherapy Tied to Slight Rise in Risk for Leukemia

Posted 14 Feb 2013 by Drugs.com

THURSDAY, Feb. 14 – Chemotherapy can be a lifesaver for thousands of cancer patients, but a new study suggests that it might slightly raise the odds for a type of leukemia later in life. Over the past 30 years, the risk for acute myeloid leukemia (AML) has increased for patients who underwent chemotherapy for certain forms of cancer, particularly non-Hodgkin lymphoma, the new study found. On the other hand, the researchers from the U.S. National Cancer Institute said other cancer survivors may have a reduced risk for AML due to a change in chemotherapy agents that occurred decades ago. One expert not connected to the study stressed that cancer patients need to put the findings into perspective. "It's important to realize that the risk of developing acute myeloid leukemia related to prior chemotherapy is small and increases with the number of chemotherapy treatments given over time," ... Read more

Related support groups: Cancer, Provera, Depo-Provera, Methotrexate, Lupron, Accutane, Tamoxifen, Medroxyprogesterone, Arimidex, Lupron Depot, Femara, Gleevec, Fluorouracil, Rituxan, Tretinoin, Zoladex, Claravis, Votrient, Tarceva, Avastin

Newer Psoriasis Drugs May Lower Heart Attack Risk for Patients

Posted 20 Aug 2012 by Drugs.com

MONDAY, Aug. 20 – People with psoriasis who take a new class of drugs known as tumor necrosis factor (TNF) inhibitors may be at a lower risk for heart attack than their counterparts who only use topical medications to treat this inflammatory skin condition, a new study shows. And patients taking older systemic medicines and phototherapy may also have a reduced heart attack risk compared to those using topical preparations, the study found. Of 8,845 study participants, about 57 percent were treated with topical therapy only, 19 percent received a TNF inhibitor for at least two months and about 24 percent were treated with other medications or phototherapy. People who were treated with TNF inhibitors had a 50 percent lower risk, and those treated with other psoriasis drugs or phototherapy had a 46 percent lower risk for heart attack, than those who used topical medications alone. The ... Read more

Related support groups: Rheumatoid Arthritis, Methotrexate, Psoriasis, Humira, Enbrel, Remicade, Cyclosporine, Cimzia, Simponi, Soriatane, Infliximab, Acitretin, Neoral, Etanercept, Adalimumab, Gengraf, Golimumab, Trexall, Methotrexate LPF Sodium, Sandimmune

FDA Medwatch Alert: Hospira Injectable Drug Products: Recall - Visible Particulates from Defective Glass Vials

Posted 18 Jul 2012 by Drugs.com

Including certain lots of the following products: carboplatin cytarabine paclitaxel methotrexate [Posted 07/16/2012] ISSUE: Hospira and FDA notified healthcare professional of a nationwide recall of certain injectable drug products, due to visible particles embedded in the glass located at the neck of the vial. There may be potential for product to come into contact with the embedded particles and the particles may become dislodged into the solution. In the event in which particulate matter could be injected into a patient, there may be the potential for patient injury where medical intervention may be required. Signs and symptoms might include bleeding, bruising, inflammation, itching, rash, chest pain and respiratory symptoms. See the Press Release for a listing of affected product lot numbers and expiration dates. BACKGROUND: These products were distributed nationwide to ... Read more

Related support groups: Cancer, Methotrexate, Carboplatin, Taxol, Paclitaxel, Cytarabine, Trexall, Cytosar-U, Methotrexate LPF Sodium, Cytosar, Folex PFS, Onxol, Rheumatrex Dose Pack, Carboplatin Novaplus, Paraplatin, Tarabine PFS

'Uncertainty' Remains Over Supply of Key Cancer Drugs

Posted 4 Jun 2012 by Drugs.com

MONDAY, June 4 – John Mahan, a 58-year-old Nashville firefighter battling a gastrointestinal cancer, couldn't believe what he was hearing last July. His doctor had just told him that his clinic had run out of injectable fluorouracil (5-FU), the generic chemotherapy Mahan needed to keep his tumor at bay. "My initial reaction was, 'you've got to be kidding, right?'" he said. Unfortunately, the news was all too real. Mahan was switched to another drug, capecitabine. Taken in pill form, it had the same anti-cancer effectiveness as 5-FU but with more onerous side effects. "It made me feel bad, weak," Mahan said, "just run down, feeling tired all of the time, loss of appetite." At a Monday news briefing at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, Mahan spoke on behalf of the thousands of cancer patients who have been hit hard by the recent nationwide ... Read more

Related support groups: Cancer, Methotrexate, Fluorouracil, Colorectal Cancer, Lymphoma, Xeloda, Taxol, Head and Neck Cancer, Paclitaxel, Capecitabine, Hodgkin's Lymphoma, Adrucil, Methotrexate LPF Sodium, Trexall, Onxol, Rheumatrex Dose Pack, Folex PFS

For Juvenile Arthritis, Pill May Work as Well as Needle

Posted 31 May 2012 by Drugs.com

THURSDAY, May 31 – Taking the arthritis drug methotrexate in pill form was just as effective as receiving it by injection for the long-term treatment of children with juvenile rheumatoid arthritis, a new study has found. Since both methods also have a similar incidence of side effects, researchers said the findings suggest that children may as well take the medication as a pill instead of having to put up with the discomfort of injections. They noted, however, that their study looked back at registry information on kids with arthritis. More research – including controlled clinical trials, the gold standard of research – is needed before making a treatment recommendation. The study, published May 30 in the journal Arthritis Care & Research, was funded by drug maker Wyeth BioPharma. Methotrexate (brand name Rheumatrex) is one of the most common first-line disease-modifying ... Read more

Related support groups: Methotrexate, Juvenile Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, Trexall, Methotrexate LPF Sodium, Folex PFS, Rheumatrex Dose Pack

Arthritis in Children Linked to Infections

Posted 1 May 2012 by Drugs.com

TUESDAY, May 1 – Children with juvenile arthritis have higher rates of bacterial infection when hospitalized than children without arthritis, a new study says. While taking high-dose steroids was associated with a higher infection risk among kids with arthritis, other arthritis drugs – methotrexate and tumor necrosis factor alpha (TNF) inhibitors – were not. Researchers analyzed Medicaid data on nearly 8,500 children with juvenile idiopathic arthritis and more than 360,000 arthritis-free children. Idiopathic means that a disease occurs without a known cause. Pharmacy claims were examined to determine arthritis patients' use of drugs that suppress the immune system, including high-dose glucocorticoids (steroids), methotrexate and TNF inhibitors, according to the study published May 1 in the journal Arthritis & Rheumatism. Kids with arthritis who were not currently treated with ... Read more

Related support groups: Prednisone, Methotrexate, Bacterial Infection, Humira, Enbrel, Remicade, Methylprednisolone, Prednisolone, Cortisone, Hydrocortisone, Medrol, Triamcinolone, Dexamethasone, Betamethasone, Cimzia, Decadron, Budesonide, Simponi, Entocort, Juvenile Rheumatoid Arthritis

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