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Inflammatory Bowel Disease Blog

Related terms: IBD

Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study

Posted 18 Jun 2014 by Drugs.com

WEDNESDAY, June 18, 2014 – A popular class of drugs used to treat inflammatory bowel disease isn't linked to an increase in the short-term risk of cancer, Danish researchers report. Researchers found that people with Crohn's disease or colitis who received the drugs – tumor necrosis factor alpha (TNF-a) antagonists – had about the same risk of cancer as other people with these inflammatory bowel diseases who were not treated with the medication. The drugs work by interrupting the function of TNF-a, a substance used by the immune system to increase inflammation. "Treatment with these drugs inhibits the inflammatory response in the gastrointestinal tract thereby leading to reduced symptoms," said lead author Dr. Nynne Nyboe Andersen of the Statens Serum Institute in Copenhagen. The problem is that TNF-a also serves a key role in protecting the body against cancer, raising concerns that ... Read more

Related support groups: Humira, Enbrel, Crohn's Disease, Remicade, Ulcerative Colitis, Colorectal Cancer, Cimzia, Simponi, Inflammatory Bowel Disease, Infliximab, Etanercept, Adalimumab, Golimumab, Certolizumab

Drug Shows Promise for People With Colitis, Crohn's Disease

Posted 21 Aug 2013 by Drugs.com

WEDNESDAY, Aug. 21 – An experimental drug may help some people who have inflammatory bowel disease that has failed to respond to current medications, two new clinical trials find. The drug, called vedolizumab, is being developed to treat the two main forms of inflammatory bowel disease (IBD) – ulcerative colitis and Crohn's disease. Both arise when the immune system launches an abnormal attack on the lining of the digestive tract, leading to chronic inflammation and symptoms such as abdominal cramps, diarrhea and rectal bleeding. In the new trials, reported in the Aug. 22 issue of the New England Journal of Medicine, researchers found that vedolizumab worked in some cases where standard IBD medications had failed. The drug was more effective for colitis than for Crohn's, however, and an expert not involved in the studies said he suspects vedolizumab might be approved for colitis ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Study Finds No Tie Between Acne Drug Accutane and Crohn's, Colitis

Posted 20 Feb 2013 by Drugs.com

WEDNESDAY, Feb. 20 – A new study counters the notion that the prescription acne drug Accutane raises the risk of Crohn's disease or colitis in women. The study of more than 45,000 women found no such link between Accutane (isotretinoin) use and these illnesses, which are collectively known as inflammatory bowel disease (IBD). One expert not connected to the study called it a "welcome review." "There has been a lot of speculation and even litigation that Accutane causes inflammatory bowel disease," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City. "Dermatologists have been discouraged from using Accutane and the makers of Accutane have discontinued their production due to countless lawsuits," she noted, but "this study once again highlights the safety of Accutane." Ulcerative colitis and Crohn's disease are the most common forms of IBD, a group of ... Read more

Related support groups: Acne, Accutane, Crohn's Disease, Colitis, Claravis, Isotretinoin, Inflammatory Bowel Disease, Amnesteem, Sotret, Myorisan, Absorica

Gene Study Yields New Clues to Crohn's Disease, Colitis

Posted 31 Oct 2012 by Drugs.com

WEDNESDAY, Oct. 31 – Scientists say research into the genetics of inflammatory bowel disease – which includes Crohn's disease and ulcerative colitis – is revealing new insights into the origin of this set of illnesses. The researchers said they have linked genetic variations in 163 regions of the human genome with a heightened risk of developing inflammatory bowel disease (IBD). Of those regions, 71 are newly discovered. IBD comprises a group of chronic, autoimmune digestive disorders that affect 2.5 million people worldwide. Symptoms include abdominal pain and diarrhea and patients typically require lifelong treatment with drug therapy. Many also require surgery to repair tissue damage caused by the disease. In this study, researchers analyzed data from about 34,000 people who took part in 15 previous studies of either Crohn's disease or ulcerative colitis. They also examined data ... Read more

Related support groups: Crohn's Disease, Colitis, Inflammatory Bowel Disease

Antibiotics in Childhood May Increase Bowel Disease Risk: Study

Posted 24 Sep 2012 by Drugs.com

MONDAY, Sept. 24 – Use of certain antibiotics may put children at higher risk for developing bowel diseases, new research has found. The earlier children take antibiotics and the more they take, the higher the risk of later developing the inflammatory bowel diseases known as Crohn's disease and ulcerative colitis, the researchers found. "There appears to be a 'dose response' effect," said Dr. Matt Kronman, assistant professor of pediatric infectious diseases at the University of Washington School of Medicine in Seattle. "The more antibiotics children took, the more their risk increased." Earlier studies had suggested a link between bowel disease and antibiotics use, but most of those studies had limitations. The new study, published online Sept. 24 in the journal Pediatrics, looked at data on more than 1 million children 17 years old or younger in nearly 500 health practices ... Read more

Related support groups: Amoxicillin, Penicillin, Metronidazole, Flagyl, Crohn's Disease, Colitis, Ulcerative Colitis, Tetracycline, Amoxil, Inflammatory Bowel Disease, Penicillin VK, Metro, Flagyl IV, Flagyl IV RTU, Amoxil Pediatric Drops, Bicillin LA, Trimox, Flagyl ER, Penicillin G Procaine, Moxatag

Travel to High Altitudes Tied to Crohn's, Colitis Flare-Ups

Posted 25 May 2012 by Drugs.com

FRIDAY, May 25 – People with inflammatory bowel disease, which includes Crohn's disease and colitis, may be at increased risk for flare-ups when they fly or travel to high altitudes for skiing or mountain climbing, a new study suggests. This complications affected patients with either Crohn's disease (which typically involves the small intestine) or ulcerative colitis (which typically involves the large intestine and rectum), but the risk appears to be higher in those with Crohn's disease, the researchers found. The study included 103 patients who were seen at inflammatory bowel disease clinics in Switzerland. The 52 patients with flares and the 51 patients who were in remission were asked about their activities during the previous month. Overall, patients with flares had made many more frequent flights or trips to areas above 6,500 feet. The study was to be presented Monday at the ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Inflammatory Bowel Disease

Birth Control Pills, HRT Tied to Digestive Ills

Posted 21 May 2012 by Drugs.com

MONDAY, May 21 – The use of oral contraceptives by younger women or hormone therapy by older women may be linked with inflammatory bowel disease, new research indicates. Birth control pills are associated with a higher risk for Crohn's disease, said researcher Dr. Hamed Khalili, a clinical and research fellow of gastroenterology at Massachusetts General Hospital in Boston. Crohn's causes inflammation of the lining and wall of the large or small intestine, or both. The lining can become so inflamed it bleeds. Hormone replacement therapy taken by some women after menopause is linked with ulcerative colitis, the study found. It is a disease of the colon (large intestine) or rectum. It causes diarrhea, abdominal cramping and rectal bleeding. Khalili presented the findings Sunday at the Digestive Disease Week meeting, in San Diego. Of the two links they found, Khalili said, the association ... Read more

Related support groups: Birth Control, Contraception, Plan B, Sprintec, Mirena, Implanon, Provera, NuvaRing, Tri-Sprintec, Yasmin, Depo-Provera, Ortho Tri-Cyclen, Loestrin 24 Fe, Lutera, Microgestin Fe 1/20, Estradiol, TriNessa, Ortho Evra, Mononessa, Ortho Tri-Cyclen Lo

Diagnostic Scans Tied to Radiation Risk for Gastro Patients

Posted 6 Apr 2012 by Drugs.com

FRIDAY, April 6 – Patients with digestive disorders such as inflammatory bowel disease may be exposed to significant levels of radiation from diagnostic imaging tests, a new study suggests. Irish researchers analyzed data from 2,590 patients with gastrointestinal disorders between 1999 and 2009, and found that 57 percent of them had undergone diagnostic imaging tests such as computed tomography (CT) imaging. Higher yearly and total levels of diagnostic radiation exposure were seen in patients with such conditions as inflammatory bowel disease, celiac disease, fatty liver disease and benign liver cysts, as well as in younger patients with irritable bowel syndrome and unexplained abdominal pain syndrome. The study appears in the April 1 online edition of the journal Clinical Gastroenterology and Hepatology. "Our results show that significant increases in radiation exposure in the last ... Read more

Related support groups: Crohn's Disease, Inflammatory Bowel Disease, Diagnosis and Investigation, Computed Tomography

Tropical Trip OK for Most With Crohn's, Colitis

Posted 27 Jan 2012 by Drugs.com

FRIDAY, Jan. 27 – Among people with inflammatory bowel disease – a chronic intestinal disorder that commonly takes the form of Crohn's disease or ulcerative colitis – those who travel to developing nations or tropical locales do not have a greater risk of intestinal infections than other travelers, according to a new study. Researchers in Israel concluded that patients with inflammatory bowel disease who have not had symptoms for at least three months actually should be encouraged to travel. They noted, however, that compared with people who don't have the condition, inflammatory bowel disease patients have a greater risk for illness when visiting industrialized countries. "Inflammatory bowel disease patients are often advised to avoid travel, especially to the developing world. However, we found that the absolute risk of illness is small and most episodes were mild," the study's ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Inflammatory Bowel Disease Less Common in Sunny States

Posted 12 Jan 2012 by Drugs.com

THURSDAY, Jan. 12 – People who live in sunnier regions of the United States are less likely to develop inflammatory bowel disease, a new study says. The findings support previous European research and could lead to new types of treatment and preventive measures, the study authors said. Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis, which can be extremely painful and require surgery. The causes of IBD remain largely unknown. In this study, researchers analyzed long-term data collected from 238,000 participants in the Nurses' Health Study I and the Nurses' Health Study II, which were launched in 1976 and 1989, respectively. None of the participants had inflammatory bowel disease at the start of the studies. Compared to participants who lived in northern areas of the United States, those living in southern areas were 52 percent less likely to develop ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

As Nations Develop, So May Bowel Disease

Posted 7 Jan 2012 by Drugs.com

FRIDAY, Jan. 6 – Inflammatory bowel disease (IBD) is becoming more common around the world, according to a new study. Researchers who analyzed data from all population-based studies about the incidence and/or prevalence of IBD found that the rate of new cases is increasing or stable in virtually every region of the world that has been studied. Canada and Europe had the highest number of cases, while Asia had a lower prevalence, the investigators found. IBD has been rare in developing nations, but incidence of the disease has increased as these countries become more industrialized, according to study lead author Dr. Gilaad Kaplan, of the University of Calgary, and colleagues. IBD includes Crohn's disease and ulcerative colitis. Crohn's involves inflammation and ulceration in the deep layers of the intestinal wall. Symptoms include abdominal pain, diarrhea, weight loss and occasional ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Chronic Bowel Disease Drugs Linked to Skin Cancer Risk

Posted 23 Nov 2011 by Drugs.com

TUESDAY, Nov. 22 – Some patients with inflammatory bowel disease may be at increased risk for skin cancer due to their use of immunosuppressant drugs to treat the intestinal disorder, according to the results of two new studies. The studies, published in the November issue of the journal Gastroenterology, noted that immunosuppressants are commonly used to treat patients with inflammatory bowel disease, or IBD. Currently, there are no specific recommendations for skin cancer screening in IBD patients. In one study, French researchers led by Dr. Laurent Peyrin-Biroulet, of University Hospital of Nancy, found that both past and present use of a widely used class of immunosuppressants called thiopurines significantly increased the risk of non-melanoma skin cancer in irritable bowel disease patients. "The increased risk of skin cancer that we found in our study was observed in all patients, ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Basal Cell Carcinoma, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance, Squamous Cell Carcinoma

Inflammatory Bowel Disease Tied to Higher Risk of Post-Op Blood Clots

Posted 20 Oct 2011 by Drugs.com

THURSDAY, Oct. 20 – Researchers report that following surgery, people with inflammatory bowel disease (IBD) may be at increased risk for blood clots known as deep vein thromboses and pulmonary embolisms. Deep vein thrombosis (DVT) is a blood clot in a deep vein in the thigh or leg – it's best known as "economy-class syndrome," after cases that occurred in passengers on long-haul flights. DVTs can travel to the lungs and lead to dangerous clots there known as pulmonary embolisms (PE). "An increased risk of DVT and PE in patients with IBD has been evident for the past 75 years," co-authors Dr. Andrea Merrill of Massachusetts General Hospital and Dr. Frederick Millham of Newton-Wellesley Hospital, both in Boston, wrote in the study published in the Oct. 17 online edition of the journal Archives of Surgery. However, they added that "most work in this area has not looked specifically at ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease

Health Tip: Coping With Inflammatory Bowel Disease

Posted 1 Sep 2011 by Drugs.com

-- People who have inflammatory bowel disease (IBD) have flares when symptoms worsen, and periods of remission when symptoms ease up. The American Gastroenterological Association offers these suggestions to help you cope with the disease, especially during flares: Learn how IBD affects your body. While foods don't cause IBD symptoms, certain foods can exacerbate symptoms. Recognize which foods make your symptoms worse, and avoid them. Take control over the factors that you are able to control. Build a support system, including support groups, friends and family. Always follow instructions given by your medical team. Read more

Related support groups: Inflammatory Bowel Disease

Hospital Infection Raises Death Risk for Bowel Patients

Posted 23 Apr 2011 by Drugs.com

FRIDAY, April 22 – Patients hospitalized for treatment of inflammatory bowel disease (IBD) have a six-fold increased risk of death if they become infected with Clostridium difficile bacteria, a new study finds. IBD includes Crohn's disease and ulcerative colitis. When people with IBD experience severe symptoms, they often require hospitalization, note the researchers at Imperial College London and St. George's Healthcare NHS Trust in the United Kingdom. They examined data on IBD patients hospitalized between 2002 and 2008 and found that those infected with C. difficile in the hospital were six times more likely to die in the hospital than those not infected with the bacteria. The death rate at 30 days was 25 percent for those with C. difficile and 3 percent for those who were free of the bacteria. The researchers also found that IBD patients with C. difficile stayed in the hospital ... Read more

Related support groups: Inflammatory Bowel Disease

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