Persistent Fluorinated Chemicals Tied to Higher Risk for Inflammatory Bowel Disease
By Lori Solomon HealthDay Reporter
FRIDAY, Jan. 12, 2024 -- Perfluoroalkyl and polyfluoroalkyl substance (PFAS) exposure is associated with later occurrence of inflammatory bowel disease (IBD), according to a research letter published online Dec. 26 in Clinical Gastroenterology and Hepatology.
Manasi Agrawal, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined the association of PFAS mixture concentrations in prediagnostic serum in patients with adult-onset IBD participating in a pilot study within the preclinical Proteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects study. The analysis included military personnel with Crohn disease (CD), those with ulcerative colitis (UC), and age-, sex-, and race-matched healthy controls (25 in each group).
The researchers found that estimated mean concentrations in the study population were 5.19 µg/L for perfluorooctane sulfonic acid, 2.57 µg/L for perfluorooctanoic acid, and 2.32 µg/L for perfluorohexane sulfonate, which were comparable to PFAS levels in the general U.S. population. Within one year of diagnosis, each one-unit increase in decile mixture of fluorinated compounds in serum samples, including the known PFAS, was associated with higher odds of CD and UC (odds ratios, 2.13 and 1.76, respectively). At all four time points up to 10 years prior to diagnosis, these associations persisted for the PFAS mixture for both CD and UC.
"Studies in larger cohorts, including analyses of pathways perturbed due to PFAS and the impact of new PFAS on disease outcomes, will be informative toward understanding IBD pathways and developing health policies to minimize exposure to harmful chemical pollutants," the authors write.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted January 2024
Read this next
Physical Activity in Middle Age Improves Health Among Women
FRIDAY, May 3, 2024 -- Adherence to physical activity guidelines during middle age appears to improve health-related quality of life among women, according to a study...
Risk for Most Cardiovascular Diseases No Higher With Inflammatory Bowel Disease
FRIDAY, May 3, 2024 -- Among postmenopausal women with inflammatory bowel disease (IBD), there is no higher risk for cardiovascular disease (CVD) compared with women without IBD...
Diabetes Increases Risk for Functional Limitations in Older Adults
FRIDAY, May 3, 2024 -- Older adults with diabetes are more likely to develop functional limitations than adults without diabetes, according to a study published online April 16 in...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.