Histologic Inflammation With IBD Tied to Serious Infections
By Lori Solomon HealthDay Reporter
FRIDAY, Dec. 8, 2023 -- Histologic inflammation with inflammatory bowel disease (IBD) is an independent risk factor for serious infections, according to a study published online Oct. 29 in Clinical Gastroenterology and Hepatology.
Karl Mårild, M.D., Ph.D., from Sahlgrenska Academy in Gothenburg, Sweden, and colleagues assessed whether serious infection risk varies by IBD histologic disease activity. The analysis included 55,626 individuals diagnosed with IBD (1990 to 2016).
The researchers found that risk for serious infection was higher for histologic inflammation versus remission (4.62 and 2.53 serious infections per 100 person-years of follow-up, respectively; adjusted hazard ratio [aHR], 1.59). There was also an increased risk for serious infection for histologic inflammation in both ulcerative colitis (aHR, 1.68) and Crohn disease (aHR, 1.59) compared with remission. A higher risk for sepsis and opportunistic infections were also seen (aHRs, 1.66 and 1.71, respectively). Results were consistent across age groups, sex, and education level and persisted after adjusting for IBD-related medications (aHR, 1.47).
"Compared with IBD patients in remission, IBD patients with histologic inflammation had an increased risk of serious infections overall and across infectious disease categories, including sepsis," the authors write. "Our findings suggest that achieving histologic remission of IBD may reduce the risk of serious infections."
Several authors disclosed ties to the pharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted December 2023
Read this next
Risk for Most Cardiovascular Diseases No Higher With Inflammatory Bowel Disease
FRIDAY, May 3, 2024 -- Among postmenopausal women with inflammatory bowel disease (IBD), there is no higher risk for cardiovascular disease (CVD) compared with women without IBD...
Following Drop After COVID-19 Onset, Inappropriate Antibiotic Prescribing Is Up
WEDNESDAY, May 1, 2024 -- There was an initial decrease in inappropriate antibiotic prescriptions following onset of COVID-19, followed by an increase, according to a study...
Multisite QI Collaborative Increases Appropriate Pediatric Antibiotic Use
MONDAY, April 29, 2024 -- A multisite collaborative increases appropriate antibiotic use for pediatric community-acquired pneumonia, skin and soft tissue infections, and urinary...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.