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Related terms: Carcinoma, Malignant Disease, Malignant Tumor

FDA Medwatch Alert: Adrucil (fluorouracil Injection, USP) 5 g/100 mL (50 mg/mL): Recall - Particulate Matter

Posted 7 hours ago by Drugs.com

ISSUE: Teva Parenteral Medicines issued a voluntary recall of eight lots of Adrucil (fluorouracil injection, USP) 5 g/100 mL (50 mg/mL) due to the potential presence of particulate matter identified as aggregate of silicone rubber pieces from a filler diaphragm and fluorouracil crystals. See the press release for a listing of affected lot numbers. Administration of an intravenous product with particulate matter has the potential to result in inflammation, allergic reactions, or blockage of blood vessels, leading to tissue death, which may be life-threatening if vital organs are affected. BACKGROUND: Adrucil Injection is used in the palliative management of carcinoma of the colon, rectum, breast, stomach and pancreas and is packaged in pharmacy bulk packages. The pharmacy bulk package has five 5 g/100ml vials per shelf pack. Individual Adrucil 5 g/100 ml vials have the NDC code ... Read more

Related support groups: Cancer, Fluorouracil, Adrucil

Age-Linked Structures on DNA May Also Hint at Cancer Risk

Posted 7 hours ago by Drugs.com

TUESDAY, May 5, 2015 – For the first time, researchers have identified a pattern of change in DNA that may signal the development of cancer long before a standard diagnosis can be made. At issue is the shifting status of telomeres in the blood. Study investigators describe telomeres as protective "caps" on the end of DNA strands. Telomeres have long been viewed as an important indicator of biological age because as people get older telomeres become shorter. The current study revealed that telomeres start to age at a faster pace than normal in people who eventually develop cancer. The study authors said that telomeres belonging to future cancer patients may shorten in length to such a degree that they resemble telomeres belonging to people 15 years older. "Understanding this pattern of telomere growth may mean it can be a predictive biomarker for cancer," study lead author Dr. Lifang ... Read more

Related support groups: Cancer, Diagnosis and Investigation

U.S. Hispanics Face Unique Health Challenges, CDC Says

Posted 7 hours ago by Drugs.com

TUESDAY, May 5, 2015 – Hispanics in the United States carry very different health risks than whites and face a tougher time getting needed medical care, according to a new federal report. Similar to whites, the two leading causes of death among Hispanics are heart disease and cancer, the U.S. Centers for Disease Control and Prevention found in its first national study of Hispanic health issues. But Hispanics are much more likely than whites to die from diabetes, homicide, or chronic liver disease and cirrhosis, the CDC researchers found. They also are more likely to be obese. The good news is that Hispanics have an overall 24 percent lower death rate than whites, as well as lower death rates for nine of the 15 leading causes of death. These include cancer, heart disease, injuries, stroke, respiratory disease, Alzheimer's disease and suicide. This phenomenon is known as the "Hispanic ... Read more

Related support groups: Obesity, Cancer, Heart Disease, Cirrhosis, Liver Cirrhosis, Diabetes Mellitus, Prevention of Cardiovascular Disease, Cardiovascular Risk Reduction

FDA Medwatch Alert: Injectable Products by Mylan: Recall - Presence of Particulate Matter

Posted 10 days ago by Drugs.com

including certain lots of: Gemcitabine for Injection Carboplatin Injection Methotrexate Injection Cytarabine Injection See the press release for a listing of the product strength, NDC, and lot numbers affected by this recall. Some products may be packaged with a Pfizer Injectables label (see Background below)   [Posted 04/24/2015] ISSUE: Mylan N.V. is conducting a voluntary nationwide recall to the hospital/user level of select lots of injectable products due to the presence of visible foreign particulate matter observed during testing of retention samples. Administration of a sterile injectable that has foreign particulates has the potential of severe health consequences. Intrathecal administration could result in a life threatening adverse event or result in permanent impairment of a body function. Intravenous administration has the potential to damage and/or obstruct blood ... Read more

Related support groups: Cancer, Methotrexate, Carboplatin, Gemzar, Gemcitabine, Cytarabine, Trexall, Cytosar-U, Cytosar, Methotrexate LPF Sodium, Rheumatrex Dose Pack, Carboplatin Novaplus, Rasuvo, Paraplatin, Otrexup, Tarabine PFS, Folex PFS

FDA Approves Cyramza (Ramucirumab) for Use with FOLFIRI in Second-Line Treatment of Metastatic Colorectal Cancer

Posted 11 days ago by Drugs.com

INDIANAPOLIS, April 24, 2015 /PRNewswire/ – Eli Lilly and Company (NYSE: LLY) has received its fourth U.S. Food and Drug Administration (FDA) approval for Cyramza (ramucirumab). Cyramza (ramucirumab injection 10 mg/mL solution) is now also indicated in combination with FOLFIRI (irinotecan, folinic acid, and 5-fluorouracil) chemotherapy for the treatment of patients with metastatic colorectal cancer (mCRC) with disease progression on or after prior therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine. "Cyramza now has approvals in advanced or metastatic forms of three of the world's most common and deadly cancers – gastric, non-small cell lung, and colorectal – with four FDA approvals received in just over a year," said Sue Mahony, Ph.D., senior vice president and president, Lilly Oncology. "This progress is encouraging and supports our ongoing development program for Cyramza. ... Read more

Related support groups: Cancer, Colorectal Cancer, Cyramza, Ramucirumab

New Technology Tests Tumors Inside the Patient to Find Best Treatment

Posted 13 days ago by Drugs.com

WEDNESDAY, April 22, 2015 – Two new devices may eventually lead to more accurate, less toxic methods of predicting how well a specific cancer drug might work on an individual's cancer, researchers report. The goal: to construct a "laboratory in a patient" method for safely exposing tumors to tiny samples of many different drugs all at once, to observe each drug's preliminary impact on the cancer, without exposing patients to the drug's potential side effects. "Different patients can respond completely differently to the same drug," explained the lead author of one of the studies, Oliver Jonas. Jonas is a post-doctoral associate in the Robert Langer Lab at the Massachusetts Institute of Technology's Institute for Integrative Cancer Research, in Cambridge. "And normally in cancer, and in some other diseases as well, there aren't good predictive markers. So you have to test therapies ... Read more

Related support groups: Cancer, Diagnosis and Investigation

Vaccine Spurs Immune Response to Fight Aggressive Cancers in Mice

Posted 13 days ago by Drugs.com

WEDNESDAY, April 22, 2015 – In a step toward personalized vaccines against cancer, scientists report they have developed an immune-system therapy that knocks out several types of aggressive tumors in mice. German researchers said the findings, reported April 22 in the journal Nature, could lead to a "blueprint" for developing tailored vaccines for a range of cancers. Such vaccines would be designed for individual patients, based on the specific genetic mutations in their tumors. The goal would be to enlist the immune system to attack the cancer – somewhat like the way standard vaccines get the immune system to prevent infections such as measles and chickenpox. Researchers have long been testing therapeutic vaccines to treat certain cancers, but it hasn't been an easy road. "For decades, we've had cancer vaccines that fail to work, and we haven't really understood why," said Dr. Lynn ... Read more

Related support groups: Cancer, Vaccination and Prophlaxis

Many Smokers Try to Quit After Cancer Diagnosis

Posted 15 days ago by Drugs.com

MONDAY, April 20, 2015 – Cancer survivors are about 50 percent more likely to quit smoking two years after their diagnosis than smokers without cancer, a new study found. While the finding buttresses the theory that a cancer diagnosis can be a "teachable moment" to promote smoking cessation, the study also revealed that a such diagnosis isn't enough to get many smokers to quit. Almost 70 percent of study participants were smoking at least two years after their diagnosis, and 57 percent were still smoking four years after being diagnosed with cancer. "This speaks to the difficulty of quitting an addiction," said study lead author J. Lee Westmaas, director of Tobacco Control Research at the American Cancer Society's Behavioral Research Center. "We also know there's evidence that cancer patients who have smoked are not followed up to see if they have quit smoking and are often not ... Read more

Related support groups: Cancer, Smoking, Smoking Cessation

Chemo for Breast Cancer Erases Woman's Fingerprints

Posted 19 days ago by Drugs.com

WEDNESDAY, April 15, 2015 – A 65-year-old breast cancer patient ran into an unexpected problem with her bank: She was denied a transaction because her fingerprints had disappeared. Reporting in the April 16 issue of the New England Journal of Medicine, doctors in Mexico said the woman's unusual case was due to the effects of chemotherapy for an advanced breast cancer that had spread to the lungs. A chemotherapy side effect called "hand-foot syndrome" appears to be tied to the fingerprint loss, wrote Drs. Yanin Chavarri-Guerra and Enrique Soto-Perez-de-Celis, of the Institute of Medical Science and Nutrition in Mexico City. They described the syndrome as "characterized by redness, swelling, and pain on the palms of the hands or soles of the feet." The patient in question experienced hand-foot syndrome that was so bad it interfered with everyday tasks, the two physicians said. "Loss of ... Read more

Related support groups: Cancer, Breast Cancer, Avastin, Xeloda, Capecitabine, Breast Cancer - Palliative, Bevacizumab

Cancer Gene Tests Should Include Healthy Tissue, Too: Study

Posted 15 Apr 2015 by Drugs.com

WEDNESDAY, April 15, 2015 – If genetic tests are only done on cancer tissue, as many as half of patients may not receive the most appropriate treatment for their cancer, a new study reports. Cancer doctors increasingly rely on genetic testing to look for opportunities to use treatments that target specific genetic causes of cancer – called targeted therapy. But doctors often examine just the genetics – or DNA – of a patient's cancerous tissue, and don't compare it against a genetic analysis of normal tissue, explained study senior author Dr. Victor Velculescu. He is a professor of oncology and pathology at Johns Hopkins University School of Medicine, and co-director of the school's Cancer Biology Program. The problem is that it's not unusual for people to have genetic variations in normal tissue that aren't causing cancer. By ignoring a person's normal genetics and only looking at ... Read more

Related support groups: Cancer, Diagnosis and Investigation

New Specialty Medicines Drive Up Drug Spending

Posted 14 Apr 2015 by Drugs.com

TUESDAY, April 14, 2015 (HealthDay New) – New medicines targeting conditions like hepatitis C, cancer and multiple sclerosis helped to propel drug spending to its highest level in more than a decade, a new report finds. Medicine sales jumped 13 percent, to nearly $374 billion, in 2014 after a period of mostly low single-digit growth, according to the report released Tuesday by the IMS Institute for Healthcare Informatics in Parsippany, N.J. Last year's increase was the largest since 2001, as spending rose 17 percent to nearly $174 billion on the growth of new "blockbuster" drugs, the report said. For the report, the IMS Institute tallies U.S. drug spending across all settings – from hospitals to retail pharmacies – and outlines the forces channeling that growth. The institute received no drug company or government funding for the report. New drug innovation, higher sticker prices and ... Read more

Related support groups: Cancer, Multiple Sclerosis, Hepatitis C

Uninsured May Face Much Higher Charges for Cancer Drugs

Posted 7 Apr 2015 by Drugs.com

TUESDAY, April 7, 2015 – Doctors may charge uninsured patients anywhere from two to 43 times what private insurance plans or Medicare pay for chemotherapy drugs, a new study estimates. Researchers said the findings, reported in the April issue of Health Affairs, highlight a fundamental inequity. "It seems that uninsured patients should not be charged more than an insurance company would pay for the same services," said lead researcher Stacie Dusetzina, an assistant professor at the University of North Carolina at Chapel Hill's Gillings School of Global Public Health. It's no surprise, she said, that uninsured patients may be charged more than the negotiated, discounted rates paid by insurance companies and Medicare – the federal health insurance program for older Americans. "What was surprising was the magnitude of the difference," Dusetzina said. Most of the charges for chemo drugs ... Read more

Related support groups: Cancer

Could Fish Oil Interfere With Cancer Care?

Posted 2 Apr 2015 by Drugs.com

THURSDAY, April 2, 2015 – Fish oil supplements, and even certain fish, may hinder the effectiveness of cancer-fighting chemotherapy, a new study suggests. Dutch researchers found herring, mackerel and three other fish oils increased blood levels of the fatty acid called 16:4(n-3) in cancer patients. Experiments in mice have suggested this fatty acid makes cancer cells resistant to chemotherapy, the researchers said. But, it's not certain that what was found to happen in mice would happen with human cancer patients. Experts noted that research on whether fish oil hurts or helps cancer patients has produced mixed results. "Dietary supplements are not necessarily benign," said Dwight Kloth, director of pharmacy at Fox Chase Cancer Center in Philadelphia, who had no role in the new study. "There are numerous cases in the literature where nutritional supplements and herbal drugs have had ... Read more

Related support groups: Cancer, Fish Oil, Lovaza, Omega-3, Omacor, MaxEPA, Omega-3 Polyunsaturated Fatty Acids, Animi-3, Marine Lipid Concentrate, Omega 3-6-9 Complex, TheraTears Nutrition, MegaKrill, Proepa, TherOmega, Sea-Omega 30, Vascazen, Super-EPA, Mi-Omega, Omtryg, Omega-500

More Americans Survive Childhood Cancers, But Health Problems Persist

Posted 1 Apr 2015 by Drugs.com

WEDNESDAY, April 1, 2015 – More Americans are surviving childhood cancers than ever before, but many suffer lingering health problems as adults, a new study finds. About 70 percent of adults who survived cancer in childhood have a mild or moderate chronic condition. And nearly one-third have a severe, disabling or life-threatening condition, the researchers found. "The fact that many of the indicators of the chronic conditions we examined increased with age was not altogether surprising. However, when you look at the age of these survivors, the magnitude of these conditions at relatively young ages is quite striking," said lead researcher Siobhan Phillips, an assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine in Chicago. Typically, these health conditions wouldn't be expected to be a problem until people are much older, Phillips said. ... Read more

Related support groups: Cancer

Harnessing the Power of the Poliovirus as a Cancer Cure

Posted 31 Mar 2015 by Drugs.com

Polio, a highly infectious and crippling disease, was certainly one of the most feared viruses in the 20th century. Each year, thousands of children were left paralyzed. Polio has been successfully eliminated in the U.S. for decades due to a widespread vaccine program. So why would a group of researchers be interested in injecting the poliovirus directly into the brain of a patient? Clinical trials are now ongoing and research is revisiting the poliovirus in new and hopeful ways, ironically to help battle deadly cancers. Glioblastoma multiforme is one of the most common and fatal brain cancers. Gliobastomas are aggressive tumors that occur in the brain or spinal cord leading to headaches, nausea, seizures, blurred vision and a host of other unpleasant effects. The tumors grow quickly and often leave patients with only months to live. Treatments for glioblastoma involve surgery to ... Read more

Related support groups: Cancer, Brain Tumor, Glioblastoma Multiforme, Malignant Glioma

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