Can Otezla make your joints hurt more?

Hell ya. I spent a week in the hospital after reaching full dosage. It's been months am weak and still in pain.

Body aches and pain is considered a more common side effect which should be reported to your Dr. if it does not subside and continues to trouble you.

Incidence not known: joint pain, stiffness, swelling

Incidence not known means:

"It means some people reported having that side effect, but there weren't enough to generate statistics to apply to a populace as a whole, or that the people who reported it were a part of an uncontrolled study."