I, like another gentleman on this website who posed a question about tiredness, just started Methotrexate. I take one dose of 12.5 mg a week. I have never experienced such a feeling of "tired" than I have after taking Methotrexate. I turn into a zombie and cannot do anything for one or two days. I just lie in bed. I have taken only two doses. In addition to feeling really tired, following a dose of this medication I feel as though I could rip somebody's head off. I feel so angry, mean and depressed and I extremely difficult to get along with though I have a husband who is very understanding. (For how long I wonder?) I am not myself. Has anyone else has experienced these side affects? Do the side affects tend to recede after time? I am hoping that this medication will do something as it has taken forever to get diagnosis of seronegative Rheumatoid arthritis. I've barely been able to walk. I am hopeful that this medication will get me onto a new road and that I will experience some improvement. I had reached a point where I felt I could not go on living in the condition I was in. Therefore I am very willing to put up with the side affects to see if they can improve my condition. Just would like to know if these side affects dissapate.
I am also being treated for a MAI infection concurrently with the arthritis. I take Rifampin, Azithromycin, and Ethambutol. I have taken these drugs for some time.