I have been treated for depression for over 20yrs and now have severe major depression for last 6 months. I take 150 mg Effexor XR and it doesn't seem to be working. I also have anxiety and panic attacks.
Responses (69) Page 2
28 Jul 2012
For ME personally a combine of celexa in the am and trazodone in the pm has been quite helpful. Also read, I have xanax for when I cant cope and adderall if I cant get outta bed for a week. And baclofen for neuromuscular spasms, that ones more medical, and what used to be serious painkiller addiction now managed with methadone.
Still some days are better than others. I like hearing from others who deal with both physical and mental torture. (Sorry, today's a kinds bad day. Rainy and t.-storms)
30 May 2012
I find it's trial an error with anti depressants. Effexor didn't do much for me either. It took a long time before we found something that worked for me. Manerix with Lithium is what finally worked for me. I find there is always restriction with all drugs so just need to adapt that all. If it works it's really worth it! I no longer have depressions now.
Good luck and take care!
5 Sep 2012
Why don't you try to increase the dose of your Effexor? 225mg is the maximum recommended dose.
I got severe depression, near suicidal, while taking Effexor and found that increasing it by 37.5 mg did the trick. The doctor said to give it 4 weeks to take effect. After 5 weeks, my depression was completely gone. Yes, completely gone!!!
So rather than playing the game of finding another anti-depressant that might work for you, try increasing the medication that has worked for you in the past.
14 Apr 2013
I have been battleing with depression all my life. Just until recently I was told i have a severe cause of magor depressions, including mental hospitalizations.jMy weight got lower sand lower but you just can force yourself to eat when not hungry. So I Talked to my dr and he changed my antideppression meds ( a few times) till finelly desuvered one that not only made eat start eating again but did gain weight at all. It really boils down to keeping a open relation ship with your dr. Even if you have to be very demandind sometimes. But in the end it is your life and you do pay for his services. And believe it or not you will feel great that you fought for yourself. Keep it up anf please never quit there it help and drs who do care very much!!! Try a new anitdepression Effexor never worked for myself either and ther are minllions out there one will work.
30 May 2012
Sorry you are having so much trouble finding an anti-depressant that works for you. I am bipolar type 2 depressed, which means I hardly ever get manic. So, essentially I have been depressed most of my life.
After pooping out on SSRI and SNRI meds, my shrink tried me on Lamictal along with my trusted old friend Klonopin. I started with a dose of 25 mg a day and maxed out at 200 mg daily. After a couple of weeks, started feeling a whole lot better. It was amazing to me. So I'm just giving you my extensive experience with anti-depressant meds, 43 years worth, the Lamictal was the answer to my prayers.
30 May 2012
Hi,sorry 2 read u have had it that long. Efexor 75mg,in the past helped me with depression,i get down at times,i önly now take valium2 relax my mind n body,and also take a stress free natural herb tablet,anti depresants dnt always wk,but we r all different,talk 2 a doc c wat else they recommend.my pschlgst 4 my anxiety a big help ,im doing gym,piltates relaxes me beta than a tablet,do u keep urself busy?i hope u find an answer 2 feel better.
30 May 2012
There are so many, and so many variables as well. What works for one does nothing for someone else. All I can offer is you stay in touch with your Dr and hopefully/eventually you'll hit on something that works for you. Be patient (no pun intended) and keep a good relationship with your Dr. Hope this helps.
30 May 2012
Well, I liked Cymbalta and I was dealing with Recurrent Major Depression with Suicidal Ideation. Two medications in my entire life have ever worked for me on that issue. The first was PARNATE an MAOInhibitor which I was on for 8 years until it seemed to stop working. The second was Cymbalta which worked quickly for me and was on up to 120mg then dropped down to 60mg. The starting dose is 30mg.
It is also possible that you may need a combination of medications: one to handle the depression and the second to handle the anxiety.
For the anxiety and to help me sleep, I take Ativan 2mg at night.
I hope that helps you and gives you some food for thought. Good luck with it and keep us posted should you need additional support or still have questions.
13 Aug 2013
There are three things that you can do 1) give some time for the effexor to work
2) you can augment effexor safely with mirtazapine starting with a low dose
3)lastly try increasing your effexor to 187.5mg. Anything more than 200mg will increase your blood pressure
if nothing works try Electroconvusive therepy with above medicatiion if you have suicidal ideas or plans.
hope it helps
Medical officer of Psychiatry
30 May 2012
It appears that u feel the same way that I feel. If u have been battling depression for 20 yrs, have u tried several ADs? If so, which ones have u tried? I recommend that u add SAM-e to your AD as soon as u can. Of course after u talk it over with your dr first. Also, if u tried most of the newer ADs then perhaps u should try the older ones, MAOIs, etc. Have u tried prozac, wellbutrin as an add-on, Paxil, Cymbalta as an add-on, SAM-e as an add on, or deplin as an add-on, inositol as an add-on, celexa or any of the popular ones that pop-up when we google medication for depression?
I recommend that u research all the ones I mention above & take the list of the ones u wanna try to your doctor. If u don't have any get up & go or if u isolate today, then u do indeed need to change meds & the sooner the better, but if u change & feel that the 4-6 week wait is taking 2 long for you, u should consider adding the SAM-e soon as possible. U can buy it from Vitacost website or Swanson's vitamin website pretty cheap. Please, please keep me posted & hang in there! God bless u!
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