Medication Guide App


Generic Name: somatropin (soe ma TROE pin)
Brand Names: Genotropin, Humatrope, Norditropin, Nutropin, Saizen, Serostim, Zorbtive

What is Zorbtive?

Zorbtive is a form of human growth hormone. Zorbtive produces effects that are identical to the body's naturally occurring growth hormone. Human growth hormone is important in the body for the growth of bones and muscles.

Zorbtive is used to treat Short Bowel Syndrome in patients who are on a specialized diet. Zorbtive will not cure Short Bowel Syndrome. Somatropin is also used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, and other causes. It is also used to prevent severe weight loss in AIDS patients.

Zorbtive may also be used for other purposes not listed here.

Important information

Before you receive Zorbtive, tell your doctor about all your past and present medical conditions, especially allergies, trauma, surgery, diabetes, cancer, breathing problems, liver or kidney disease, scoliosis, high blood pressure, pancreas disorder, underactive thyroid, or a brain tumor.

Also tell your doctor about all other medications you use, especially steroids or diabetes medications. Your dosages of these medicines may need to be changed when you start using Zorbtive.

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Do not stop using a steroid suddenly or change any of your medication doses without your doctor's advice

When taking Zorbtive to treat short bowel syndrome, it is very important to follow the diet plan created for you by your doctor or nutrition counselor. Zorbtive is not a cure for short bowel syndrome.

If you have Prader-Willi syndrome and are using somatropin, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.

Call your doctor at once if you have sudden and severe pain in your upper stomach with nausea and vomiting, fast heartbeat, increased thirst or urination, weight loss, or vision changes and sudden, severe pain behind your eyes.

Read and carefully follow the instructions provided with Zorbtive about proper storage before and after it has been mixed.

Before using Zorbtive

Before you receive Zorbtive, tell your doctor if you have ever had an allergic reaction to a growth hormone medicine, or to drug preservatives such as benzyl alcohol, metacresol or glycerin.

You should not use Zorbtive if you are allergic to somatropin, or if you have:

  • diabetic retinopathy (a serious eye condition caused by diabetes);

  • cancer; or

  • Prader-Willi syndrome and are also overweight or have sleep apnea or severe respiratory (lung) problems.

You should also not use Zorbtive if you have a serious medical condition after having:

  • open heart surgery or stomach surgery;

  • trauma or other medical emergency; or

  • breathing problems (such as lung failure).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using Zorbtive, tell your doctor if you have:

  • liver disease;

  • kidney disease (or if you are on dialysis);

  • diabetes;

  • a pituitary gland disorder;

  • scoliosis;

  • high blood pressure (hypertension);

  • a pancreas disorder (especially in children);

  • a history of cancer;

  • carpal tunnel syndrome;

  • underactive thyroid; or

  • a brain tumor or lesion.

FDA pregnancy category B. Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, Serostim,and Zorbtive.

See also: Pregnancy and breastfeeding warnings (in more detail)

Other brands of somatropin are in FDA pregnancy category C. It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin, Nutropin, and Tev-tropin.

Tell your doctor if you are pregnant or plan to become pregnant while using Zorbtive.

It is not known whether somatropin passes into breast milk or if it could harm a nursing baby. Do not use Zorbtive without telling your doctor if you are breast-feeding a baby.

How should I use Zorbtive?

Use Zorbtive exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Zorbtive is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Use a different place on your body each time you give the Zorbtive injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Do not inject this medicine into skin or muscle that is red, sore, infected, or injured.

Do not shake the medication bottle or you may ruin the medicine. When mixing Zorbtive with a diluent (liquid), use a gentle swirling motion. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure Zorbtive is helping your condition and not causing harm, your blood and growth progress will need to be tested often. Your eyes may also need to be checked. Visit your doctor regularly.

If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Zorbtive is not a cure for short bowel syndrome.

After mixing Zorbtive, use it right away. You can save any unused portion of Zorbtive solution remaining in the vial and store in a refrigerator until your next dose. On the next dose, mix a new vial of Zorbtive. Then, draw up the remaining medication from the refrigerated vial, emptying the vial. Draw up the balance of prescribed dose from the new vial, until the dose amount is reached. Read and carefully follow the instructions provided with your medicine about proper storage of Zorbtive before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.

Throw away any Zorbtive left over after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than 3 doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.

What should I avoid?

If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. Follow the instructions of your doctor or nutrition counselor about what types of liquids you should drink while using Zorbtive.

Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.

Zorbtive side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Zorbtive: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  • increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss;

  • sudden and severe pain behind your eyes, vision changes;

  • swelling in your head, face, hands, or feet; or

  • numbness or tingling in your wrist, hand, or fingers.

Less serious Zorbtive side effects may include:

  • headache, feeling tired;

  • redness, soreness, swelling, rash, itching, pain, or bruising where the medicine was injected;

  • pain in your arms or legs, joint stiffness or pain;

  • muscle pain; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Zorbtive?

Before using Zorbtive, tell your doctor if you use insulin or take oral (by mouth) medicine to treat diabetes. Zorbtive may affect blood sugar levels and you may need to adjust your dose of the diabetes medication. Do not change the dose of your diabetes medication without your doctor's advice.

Tell your doctor if you use any type of steroid medicine such as cortisone, dexamethasone, methylprednisolone, prednisone, and others. Steroids can make somatropin less effective and your doses may need to be adjusted. Steroids can make Zorbtive less effective and your doses may need to be adjusted. Do not stop using a steroid suddenly. Follow your doctor's instructions.

Tell your doctor about all other medications you use, especially cyclosporine (Gengraf, Neoral, Sandimmune), seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women.

This list is not complete and there may be other drugs can interact with Zorbtive. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Zorbtive.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zorbtive only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2015 Cerner Multum, Inc. Version: 12.01. Revision Date: 8/10/2011 3:24:13 PM.