View full screen / Print PDF » Download PDF ⇩

Please read this leaflet carefully before you
start to take this medicine.
• If you have further questions, please ask
your doctor or your pharmacist.
• This medicine has been prescribed for you
personally and you should not pass it on to
others. It may harm them, even if their
symptoms are the same as yours.
• Keep this leaflet; you may need to read it
1. What your medicine is and what it is used for
2. Before you take your medicine
3. How to take your medicine
4. Possible side effects
5. Storing your medicine
6. More information



The name of your medicine is Doxycycline 100mg
Capsules. It belongs to a group of medicines
called tetracycline antibiotics. It may be used to
treat a wide range of infections caused by
bacteria, these include:
• Chest, lung or nasal infections e.g. bronchitis,
pneumonia, sinusitis
• Infections of the kidneys and bladder e.g.
cystitis, urethritis
• Infections of the skin such as acne
• Eye infections
• Sexually transmitted diseases e.g. gonorrhoea,
syphilis, chlamydia
• Rickettsial infections such as Q fever or fevers
associated with louse or tick bites
• Malaria, when chloroquine is not effective
• Other infections such as cholera, brucellosis,
leptospirosis and psittacosis
Doxycycline capsules are also used to prevent
certain infections developing such as scrub
typhus, traveller’s diarrhoea, malaria and
leptospirosis (a bacterial infection caused by
exposure to bacteria in fresh water contaminated
by animal urine).



Do not take your medicine and tell your doctor,
if you:
• have taken Doxycycline or any other antibiotic
before and suffered an allergic reaction (e.g.
rash, itching, swelling of the face, fainting and
breathing problems)
• are allergic to any of the other ingredients in
Doxycycline Capsules (see section 6 More
• are pregnant or trying to become pregnant
• are breast-feeding
• are giving it to a child under 12 years of age
Important information about one of the
ingredients in this medicine
Doxycycline 100mg Capsules contain sucrose. If
you have been told by your doctor that you have
an intolerance to some sugars, contact your
doctor before taking this medicinal product.
Take special care with your medicine
You should let your doctor know and ask their
advice, if you:
• are likely to be exposed to strong sunlight or
ultraviolet light (e.g. on a sunbed)
• have liver problems or are taking medicines
which affect your liver
• have severe kidney problems
• have myasthenia gravis (a disease which
causes unusual tiredness and weakness of
certain muscles, particularly in the eyelid,
difficulty chewing and swallowing and slurred
• have porphyria (a rare genetic disease of blood
• have systemic lupus erythematosus (SLE) a
condition characterised by a rash (especially on
the face), hair loss, fever, malaise and joint
pain. This condition may be worsened by taking
Taking other medication
Please tell your doctor or pharmacist if you are
taking or have recently taken any other medicines,
including medicines obtained without a
prescription. Especially:
• Penicillin antibiotics (used to treat infections)
• Rifampicin (used to treat tuberculosis)
• Anticoagulants (used to thin the blood, e.g.
• Quinapril (used to lower high blood pressure)

• Kaolin (used to treat diarrhoea)
• Sucralfate (used to treat and prevent stomach
• Oral contraceptives (‘The Pill’). This medicine
may make the oral contraceptive pill less
effective. You should use additional
contraceptive precautions whilst taking this
medicine and for 7 days after stopping.
• Barbiturates (strong sleeping tablets, e.g.
• Ergotamine or methysergide (used to treat
migraines or headaches)
• Typhoid vaccine (used to prevent typhoid fever
if travelling to infected areas of the world)
• Carbamazepine, phenytoin, primidone or other
drugs used to control epilepsy
• Ciclosporin (used to affect the body’s immune
response following organ transplants)
• Methoxyflurane (an anaesthetic). If you need an
operation, tell your doctor or dentist that you are
taking Doxycycline.
• Methotrexate (used to treat cancer, psoriasis or
rheumatoid arthritis)
• Medicines such as antacids (indigestion tablets
or liquids) containing aluminium, calcium,
magnesium or other medicines containing iron,
bismuth or zinc salts, should not be taken at the
same time as your medicine, as absorption of
your medicine may be reduced
• Retinoids (used to treat various skin conditions)
Alcohol may reduce the effect of your medicine. It
is therefore advisable to avoid drinking any
Pregnancy and breast-feeding
If you are pregnant, planning to become pregnant
or are breast-feeding ask your doctor or
pharmacist for advice before taking any medicine
as Doxycycline could harm the baby.
Driving and using machines
Do not drive or use machines if you suffer from
visual disturbances such as blurring of vision while
taking Doxycycline.



Always take your medicine exactly as your doctor
has instructed you. You should check with your
doctor or pharmacist, if you are unsure. Do not
take more than your doctor has recommended.

Your medicine should be taken by mouth as
• You must take your capsules as your doctor
has told you to.
• It is important to swallow each doxycycline
capsule whole with a glass of water.
• It is best to take your capsules at the same
time(s) each day, when standing or while sitting.
• It is important not to lie down for at least thirty
minutes after taking Doxycycline capsules, so
that the capsule can move as swiftly as possible
into the stomach and prevent irritation of the
throat or oesophagus (canal taking food from
the mouth to the stomach).
• If your stomach is upset, Doxycycline capsules
can be taken with milk or a meal.
Adults and the elderly
Respiratory, urinary tract, ophthalmic and
other infections
The usual dose is 200mg on the first day as a
single dose or two 100mg doses, followed by
100mg daily. For severe infections your doctor
may increase the dose to 200mg a day. The
duration of treatment is dependent on the infection
being treated.
50mg daily for 6-12 weeks, with food or fluid.
Sexually transmitted diseases
100mg twice daily for 7-10 days.
Primary and secondary syphilis
300mg daily in divided doses for at least 10 days.
Fevers associated with louse or tick bites
Single dose of 100mg or 200mg depending on
Treatment of malaria, when chloroquine is not
200mg daily for at least 7 days.
Prevention of malaria
100mg daily for 1-2 days before travelling until 4
weeks after returning.
Prevention of scrub typhus
Single dose of 200mg.

Dimensions: 297mm x 210mm
Pantone Blue
280 C

DIMENSIONS 297 x 210mm


Prevention of leptospirosis
200mg once each week during the stay in the
area; 200mg on completion of the trip. If you are
planning to take these capsules for more than 21
days, please consult your doctor.
Doctors may prescribe different doses to these
depending on the infection being treated. Check
with your doctor if you are not sure why you have
been prescribed the medicine.
The label on the pack will tell you what dose YOU
should take, how often and for how long to take it.
If you are still not sure, ask your doctor or
Children over 12 years of age
The recommended dosage schedule for children
over 12 years of age, weighing 50kg or less is
4 mg/kg of body weight on the first day of
treatment (given as a single dose or divided into
two equal doses with a 12 hour interval), followed
by 2 mg/kg of body weight on subsequent days.
For more severe infections up to 4 mg/kg of body
weight may be used daily.
For children over 50 kg the usual adult dose
should be used.
Children under 12 years of age
Doxycycline capsules are not recommended for
use in children under 12 years of age as it can
cause permanent discolouration of tooth enamel
and affect bone development.
Overdose: If you take more of your medicine
than you should
If you (or someone else) swallow a lot of capsules
at the same time, or you think a child may have
swallowed any, contact your nearest hospital
casualty department or tell your doctor
If you forget to take your medicine
Do not take a double dose to make up for a
forgotten dose. If you forget to take a dose take it
as soon as you remember it and then take the
next dose at the right time.

If you stop taking your medicine
Do not stop treatment early as your infection may
return if you do not finish the course of capsules.



Like all medicines, Doxycycline can cause side
effects, although not everybody gets them.
Stop taking your medicine and tell your doctor
immediately, or go to accident and emergency
if you notice any of the following symptoms.
Although the symptoms are very rare, they
may be severe.
• Symptoms of an allergic reaction - sudden
wheeziness, difficulty in breathing, chest pain,
fever, sudden swellings of the face, lips, tongue,
throat, hands or feet, rash or itching (especially
affecting the whole body), pericarditis
(inflammation of the membrane surrounding the
heart), worsening of systemic lupus
erythematosus (autoimmune disease)
If you experience any of the side effects listed
below, tell your doctor as soon as possible:
• Severe skin reactions such as erythema
multiforme (circular, irregular red patches),
Stevens-Johnson syndrome (rash with flushing,
fever, blisters or ulcers), toxic epidermal
necrolysis (reddening, peeling and swelling that
resembles burns)
• Sensitivity to sunlight - you may get a skin rash,
itching, redness or severe sunburn when out in
sunlight or after using a sun bed
• Increased pressure in the skull (severe
headaches, blurred and/or double vision, blind
spots, permanent loss of vision)
• Bulging fontanelles (soft spot on head) of
• Swollen tongue, severe watery or bloody
diarrhoea, fever and cramps
(pseudomembranous colitis)
• Low blood pressure
• Aches in the joints or muscles
• Unusual rapid heart beats (palpitations),
• Blood disorders (symptoms may include
tiredness, weakness, easy bruising or
susceptibility to infection)
• Porphyria (sensitivity of the skin to sunlight,
inflammation of nerves and stomach pains)
• Discolouration of thyroid tissue (does not affect
thyroid function)
• Changes in liver function tests

• Hepatitis (inflammation of the liver)
• Liver failure
• An increase in urea in the blood
• Jaundice (yellowing of the skin or white of the
eyes) has rarely been reported
• Pancreatitis (manifested by severe upper
abdominal pain) has rarely been reported
• Discolouration or underdevelopment of teeth
• Loosening of the nail from the nail bed after
exposure to the sun
Most of these side effects are infrequent but if
they persist or are troublesome you should
see your doctor.
• Inflammation and/or ulcers of the
gastrointestinal tract (symptoms may include
sore mouth, indigestion and difficulty
• Feeling or being sick, diarrhoea
• Loss of appetite
• A ringing or buzzing noise in the ear
• Soreness and itching of the rectal and/or genital
• Yeast infection around the anus or genitals
The list of side effects mentioned above is not
complete. If you should suffer from any of these
side effects or any other undesired effect please
tell your doctor or pharmacist. Do not be alarmed
by this list of possible side effects. You may not
experience any of them.



Do not use your medicine after the expiry date
shown on the blister and carton. The expiry date
refers to the last day of that month.
Store below 25°C. Store in the original package.
Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the



What your medicine contains
The active substance (the ingredient that make
the capsules work) is doxycycline hyclate.
The other ingredients in the capsule are sucrose,
maize starch, crospovidone, polymethacrylate and
The capsule shell contains gelatin and the
colourings E171, E132 and E172.
The white printing contains shellac, propylene
glycol, ammonium hydroxide, potassium
hydroxide and the colour E171.
What your medicine looks like
Doxycycline capsules are opaque green capsules
with “100mg” printed in white ink.
The capsules are available in packs of 8, 10, 14
and 50 capsules. Not all pack sizes may be
Marketing Authorisation Holder
Kent Pharmaceuticals Limited, Repton Road,
Measham, DE12 7DT, U.K.
Company responsible for release of this
Kent Pharmaceuticals Ltd, Crowbridge Road,
Ashford, Kent, TN24 0GR, U.K.
Kent Pharmaceuticals Limited, Repton Road,
Measham, DE12 7DT, U.K.


Prevention of travellers’ diarrhoea
100mg twice daily on the first day of travel,
followed by 100mg daily throughout the stay in the
area. If you are planning to take these capsules
for more than 21 days, please consult your doctor.

Distributor: Almus Pharmaceuticals, 43 Cox
Lane, Chessington, KT9 1SN, UK
PL 08215/0009
This leaflet was last revised in July 2013.


Dimensions: 297mm x 210mm
Pantone Blue
280 C

Expand view ⇕

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Learn about treatments for OA knee pain to help you stay active. Watch Video