Ziconotide Side Effects

It is possible that some side effects of ziconotide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ziconotide: intrathecal solution

As well as its needed effects, ziconotide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ziconotide, check with your doctor or nurse immediately:

More common
  • Anxiety
  • being forgetful
  • change in walking and balance
  • changes in patterns and rhythms of speech
  • clumsiness or unsteadiness
  • confusion
  • decrease in the frequency of urination
  • decrease in urine volume
  • delusions
  • dementia
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • feeling unusually cold
  • painful urination
  • problems with speech or speaking
  • seeing, hearing, or feeling things that are not there
  • shakiness and unsteady walk
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • slurred speech
  • thoughts of killing oneself
  • trembling or shaking of the hands or feet
  • uncontrolled eye movements
  • unsteadiness, trembling, or other problems with muscle control or coordination
Less common
  • Aggressive or angry
  • chest pain
  • chills
  • confusion as to time, place, or person
  • convulsions
  • cough
  • dark-colored urine
  • dizziness
  • drowsiness
  • fainting
  • fast heartbeat
  • fearfulness, suspiciousness, or other mental changes
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • fever
  • general feeling of illness
  • holding false beliefs that cannot be changed by fact
  • lightheadedness
  • muscle spasm or jerking of all extremities
  • muscle stiffness
  • rapid, shallow breathing
  • severe mood or mental changes
  • shortness of breath
  • sneezing
  • sore throat
  • stiff neck or back
  • tightness in the chest
  • troubled breathing
  • trouble in concentration
  • trouble in sleeping
  • unusual behavior unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • wheezing
Rare
  • Actions that are out of control
  • changes in behavior
  • irritability
  • talking, feeling, and acting with excitement
Incidence not known
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

If any of the following symptoms of overdose occur while taking ziconotide, get emergency help immediately:

Symptoms of overdose
  • Decreased awareness or responsiveness
  • severe sleepiness

Some ziconotide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Blurred vision
  • crawling feelings
  • diarrhea
  • dizziness
  • dizziness or lightheadedness
  • excessive muscle tone, tension, or tightness
  • feeling of constant movement of self or surroundings
  • headache
  • itching
  • lack or loss of strength
  • loss of appetite
  • loss of memory
  • nausea
  • pain in the arms or legs
  • problems with memory
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • vomiting
  • weight loss
Less common
  • Acid or sour stomach
  • back pain
  • bad, unusual, or unpleasant (after) taste
  • belching
  • bladder pain
  • bloody or cloudy urine
  • bruising
  • change in taste
  • congestion
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • crying
  • dehydration
  • depersonalization
  • depression
  • difficulty seeing at night
  • difficulty with moving
  • double vision
  • dry mouth
  • dry skin
  • dysphoria
  • euphoria
  • fainting
  • frequent urge to urinate
  • hearing loss
  • heartburn
  • hoarseness
  • increased sensitivity of the eyes to sunlight
  • increased sensitivity to pain or touch
  • indigestion
  • loss of bladder control
  • loss of taste
  • lung disorder
  • nerve pain
  • pain in the joints
  • pain or tenderness around the eyes and cheekbones
  • pale skin
  • pounding in the ears
  • quick to react or overreact emotionally
  • rapidly changing moods
  • red, scaly, swollen, or peeling areas of the skin
  • redness or pain at the catheter site
  • runny nose
  • severe muscle stiffness
  • shortness of breath or troubled breathing
  • sleeplessness
  • slow or fast heartbeat
  • stomach discomfort, upset, or pain
  • stuffy nose
  • sweating
  • swelling or redness in the joints
  • tender, swollen glands in the neck
  • tightness of the chest or wheezing
  • trouble with swallowing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • warmth on the skin
  • weakness or heaviness in the legs
Incidence not known
  • Burning sensation on the skin
  • flaking and falling off of skin
  • skin blisters
  • sores on the skin

For Healthcare Professionals

Applies to ziconotide: intrathecal solution

Nervous system

Nervous system side effects including dizziness (up to 47%), confusion (18% to 33%), somnolence (up to 22%), memory impairment (7% to 22%), ataxia (up to 16%), abnormal gait (15%), speech disorder (9% to 14%), headache (13%), aphasia (8% to 12%), hypertonia (11%), nystagmus (8%), abnormal thinking (8%), amnesia (up to 8%), dysesthesia (7%), hallucinations (7%), nervousness (7%), paresthesia (7%), tremor (7%), dysarthria (7%), vertigo (up to 7%), and dysgeusia (5%) have been reported. Abnormal dreams, agitation, abnormal cerebrospinal fluid, depression, difficulty concentrating, dry mouth, emotional lability, hostility, hyperesthesia, incoordination, mental slowing, meningitis, neuralgia, paranoid reaction, decreased reflexes, stupor, and twitching have been reported in at least 2% of patients participating in the clinical trials. Cerebrovascular accident, grand mal convulsion, meningitis, myoclonus, and rhabdomyolysis have been reported in less than 2% of patients participating in the clinical trials.

A 42% incidence of confusion has been reported in patients 65 years of age and older. A 29% incidence of confusion has been reported in patients under 65 year of age.

Cognitive impairment may appear gradually after several weeks of treatment. The various cognitive effects of ziconotide are generally reversible within 2 weeks after drug discontinuation.

Gastrointestinal

Gastrointestinal side effects including nausea (up to 41%), diarrhea (up to 19%), vomiting (up to 16%), and anorexia (up to 10%) have been reported. Constipation, gastrointestinal disorder, nausea, nausea with vomiting, and dyspepsia have been reported in at least 2% of patients participating in the clinical trials.

Hepatic

Hepatic side effects have included serum creatine kinase (CK) levels above the upper limit of normal (40%). Eleven percent of patients had serum CK that were 3 or more times the upper limit of normal.

In cases where CK was fractionated, only the muscle isoenzyme (MM) was elevated.

General

General side effects including asthenia (up to 22%), headache (15%), abnormal gait (14%), pain (11%), rigors (7%), and fever (up to 7%) have been reported. Abdominal pain, accidental injury, back pain, catheter complication, cellulitis, chest pain, infection, malaise, neck pain, neck rigidity, and flu syndrome have been reported in at least 2% of patients participating in the clinical trials.

Psychiatric

Psychiatric side effects including confusional state (15%), hallucinations (12%), anxiety (8%), insomnia (6%), paranoid reactions (3%), hostility (2%), delirium (2%), psychosis (1%), and manic reactions (0.4%) have been reported.

Ocular

Ocular side effects including blurred vision (12%) and abnormal vision (10%) have been reported. Diplopia and photophobia have been reported in at least 2% of patients participating in the clinical trials.

Local

Local side effects have included catheter site pain, pump site pain, pump site complication, and pump site mass which have been reported in at least 2% of patients participating in the clinical trials.

Cardiovascular

Cardiovascular side effects including hypertension, hypotension, postural hypotension, syncope, tachycardia, and vasodilation have been reported in at least 2% of patients participating in the clinical trials. Atrial fibrillation and abnormal cardiograms have been reported in less than 2% of patients participating in the clinical trials.

Hematologic

Hematologic side effects including anemia and ecchymosis have been reported in at least 2% of patients participating in the clinical trials.

Metabolic

Metabolic side effects including increased creatinine phosphokinase, dehydration, edema, hypokalemia, peripheral edema, and weight loss have been reported in at least 2% of patients participating in the clinical trials.

Musculoskeletal

Musculoskeletal side effects including arthralgia, arthritis, leg cramps, myalgia, muscle spasm, limb pain, and myasthenia have been reported in at least 2% of patients participating in the clinical trials.

Respiratory

Respiratory side effects including bronchitis, increased cough, dyspnea, lung disorder, pharyngitis, pneumonia, rhinitis, and sinusitis have been reported in at least 2% of patients participating in the clinical trials. Respiratory distress has been reported in less than 2% of patients participating in the clinical trials. Fatal aspiration pneumonia has been reported in less than 1% of patients participating in clinical trials.

Dermatologic

Dermatologic side effects including cutaneous surgical complication, dry skin, pruritus, rash, skin disorder, and sweating have been reported in at least 2% of patients participating in the clinical trials.

Other

Other side effects including vertigo have been reported in 7% of patients. Taste perversion and tinnitus have been reported in at least 2% of patients participating in the clinical trials. Sepsis and suicidal ideations have been reported in less than 2% of patients participating in the clinical trials.

Renal

Renal side effects including urinary retention (9%) have been reported. Urinary incontinence, urinary tract infection, and impaired urination have been reported in at least 2% of patients participating in the clinical trials. Acute kidney failure has been reported in less than 2% of patients participating in the clinical trials.

Genitourinary

Genitourinary side effects including urinary retention (9%) have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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