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Xylocaine Topical Side Effects

Generic Name: lidocaine topical

Note: This page contains side effects data for the generic drug lidocaine topical. It is possible that some of the dosage forms included below may not apply to the brand name Xylocaine Topical.

It is possible that some side effects of Xylocaine Topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to lidocaine topical: topical application aerosol liquid, topical application cream, topical application dressing, topical application foam, topical application gel/jelly, topical application lotion, topical application ointment, topical application pad, topical application patch extended release, topical application powder, topical application solution, topical application spray

As well as its needed effects, lidocaine topical (the active ingredient contained in Xylocaine Topical) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking lidocaine topical, check with your doctor immediately:

Rare
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cough
  • cracked, dry, or scaly skin
  • fast heartbeat
  • fever
  • hives or welts, itching, or skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
Incidence not known
  • Blistering, bruising, burning, discoloration, itching, redness, or swelling at the application site
  • blurred vision
  • chest pain or discomfort
  • cold, clammy, or pale skin
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness or dizziness
  • false or unusual sense of well-being
  • fear or nervousness
  • irregular, fast or slow, or shallow breathing
  • lethargy
  • no blood pressure or pulse
  • pale or blue lips, fingernails, or skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness in the legs, arms, hands, or feet
  • slow heart rate
  • slow or irregular heartbeat
  • stopping of heart
  • trembling or shaking of the hands or feet
  • twitching
  • unconsciousness
  • unusual tiredness or weakness
  • weakness

Some lidocaine topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • cold or numbness
  • confusion about identity, place, and time
  • continuing ringing or buzzing or other unexplained noise in the ears
  • double vision
  • headache
  • hearing loss
  • heat sensation
  • lack or loss of strength
  • metallic taste
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to lidocaine topical: intradermal device, mucous membrane solution, mucous membrane spray, topical cream, topical film, topical gel, topical gel with applicator, topical kit, topical liquid, topical lotion, topical ointment, topical solution, topical spray, topical stick

General

The most common adverse events were administration site reactions: burning, dermatitis, erythema, pruritus, rash, skin irritation, and vesicles.[Ref]

Dermatologic

Very common (10% or more): Erythema (up to 67.3%), petechiae (up to 46.4%)
Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Skin lesion, skin injury
Frequency not reported: Flushing, cutaneous lesions, urticaria, dermatitis[Ref]

Local

Very common (10% or more): Administration site reactions
Common (1% to 10%): Irritation, redness, itching, application site erythema, application site burning, application site pain, application site pruritus, edema
Uncommon (0.1% to 1%): Venipuncture site hemorrhage, burning sensation
Frequency not reported: Locus of abnormal sensation, paleness (pallor or blanching), alteration in temperature sensation, blisters, bruising, depigmentation, dermatitis, discoloration, exfoliation, papules, petechiae, vesicles, application site dermatitis, application site vesicles, skin irritation[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Dizziness
Frequency not reported: Lightheadedness, nervousness, apprehension, euphoria, confusion, drowsiness, tinnitus, nystagmus, headache, nausea, vomiting, sensations of heat, cold or numbness, twitching, tremors, paraesthesia, convulsions, unconsciousness, respiratory depression and arrest, pain and/or dysesthesia in the buttocks or legs, unconsciousness
Postmarketing reports: Headache, hyperesthesia, hypoesthesia, lightheadedness, metallic taste, somnolence, taste alteration[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting[Ref]

Immunologic

Common (1% to 10%): Nasopharyngitis[Ref]

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic reaction, hypersensitivity
Frequency not reported: Anaphylactoid reactions, anaphylactic shock, angioedema, bronchospasm, shock, dyspnea, laryngospasm[Ref]

Cardiovascular

Frequency not reported: Bradycardia, hypotension, arrhythmia, cardiovascular collapse, cardiac arrest, AV block, myocardial depression[Ref]

Hematologic

Frequency not reported: Methemoglobinemia[Ref]

Ocular

Frequency not reported: Corneal irritation, blurred or double vision
Postmarketing reports: Visual disturbances[Ref]

Respiratory

Rare (less than 0.1%): Endotracheal tube occlusion
Frequency not reported: Sore throat, hoarseness, loss of voice[Ref]

Psychiatric

Frequency not reported: Confusion, psychosis, disorientation, dizziness[Ref]

Other

Postmarketing reports: Open wound, asthenia, pain exacerbated[Ref]

References

1. "Product Information. LMX 4 (lidocaine topical)." Ferndale Laboratories Inc, Ferndale, MI.

2. "Product Information. Zingo (lidocaine topical)." Sagent Pharmaceuticals, Inc., Schaumberg, IL.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Lidoderm (lidocaine topical)." Endo Laboratories LLC, Chaddsford, PA.

6. Gammaitoni AR, Davis MW "Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing." Ann Pharmacother 36 (2002): 236-40

7. Gammaitoni AR, Alvarez NA, Galer BS "Pharmacokinetics and safety of continuously applied lidocaine patches 5%." Am J Health Syst Pharm 59 (2002): 2215-20

8. "Product Information. Xylocaine 2% jelly (lidocaine topical)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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