Xerava Side Effects

Generic name: eravacycline

Medically reviewed by Drugs.com. Last updated on Nov 21, 2023.

Note: This document contains side effect information about eravacycline. Some dosage forms listed on this page may not apply to the brand name Xerava.

Applies to eravacycline: intravenous powder for solution.

Serious side effects of Xerava

Along with its needed effects, eravacycline (the active ingredient contained in Xerava) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking eravacycline:

Less common

• Bleeding wound
• blurred vision
• confusion
• diarrhea
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• red, tender, or oozing skin at the incision site
• sweating
• unusual tiredness or weakness

Rare

• Black, tarry, stools
• bloating
• chest pain
• chills
• constipation
• cough
• dark urine
• difficult or labored breathing
• fast, irregular, pounding, or racing heartbeat or pulse
• fever
• hives, itching, skin rash
• hoarseness
• indigestion
• irritation
• joint pain, stiffness or swelling
• loss of appetite
• lower back or side pain
• mood or mental changes
• muscle cramps in the hands, arms, feet, legs, or face
• nausea
• numbness and tingling around the mouth, fingertips, or feet
• painful or difficult urination
• pains in the stomach, side, or abdomen, possibly radiating to the back
• pale skin
• redness of the skin
• seizures
• sore throat
• stomach cramps
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• tremor
• troubled breathing or swallowing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• vomiting
• yellow eyes or skin

Other side effects of Xerava

Some side effects of eravacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Dry, red, hot, or irritated skin

Rare

• Anxiety
• change in taste
• discouragement
• feeling sad or empty
• loss of interest or pleasure
• loss of taste
• trouble concentrating
• trouble sleeping

For Healthcare Professionals

Applies to eravacycline: intravenous powder for injection.

General

The most common side effects were infusion site reactions, nausea, and vomiting. This drug was discontinued due to side effects in 2% of patients (compared to 2% for comparator); discontinuation was most often due to gastrointestinal disorders.^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, thrombophlebitis (includes thrombophlebitis, infusion site thrombosis), phlebitis (includes phlebitis, infusion site phlebitis, superficial phlebitis, injection site phlebitis)

Frequency not reported: Palpitations

Dermatologic

Uncommon (0.1% to 1%): Rash, hyperhidrosis

Tetracycline class:

-Frequency not reported: Photosensitivity

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, diarrhea

Uncommon (0.1% to 1%): Pancreatitis

Frequency not reported: Acute pancreatitis, pancreatic necrosis, increased amylase, increased lipase

Antibiotic class:

-Uncommon (0.1% to 1%): Treatment-related diarrhea

-Frequency not reported: Pseudomembranous colitis

Hematologic

Frequency not reported: Prolonged activated partial thromboplastin time, decreased WBC count, neutropenia

Hepatic

Uncommon (0.1% to 1%): Increased ALT, increased AST, hyperbilirubinemia

Frequency not reported: Increased GGT

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Local

Common (1% to 10%): Infusion site reactions (includes catheter/vessel puncture site pain, infusion site extravasation, infusion site hypoesthesia, infusion/injection site phlebitis, infusion site thrombosis, injection site/vessel puncture site erythema, phlebitis, superficial phlebitis, thrombophlebitis, vessel puncture site swelling, injection site pain/discomfort, injection site swelling/inflammation), infusion site phlebitis

Uncommon (0.1% to 1%): Infusion site thrombosis, vessel puncture site erythema, infusion site hypoesthesia

Metabolic

Frequency not reported: Hypocalcemia

Nervous system

Uncommon (0.1% to 1%): Dizziness, headache

Frequency not reported: Dysgeusia

Tetracycline class:

-Frequency not reported: Pseudotumor cerebri

Other

Common (1% to 10%): Wound dehiscence

Frequency not reported: Chest pain

Antibiotic class:

-Frequency not reported: Overgrowth of nonsusceptible organisms (including fungi)

Tetracycline class:

-Frequency not reported: Antianabolic action (leading to increased BUN, azotemia, acidosis, hyperphosphatemia)

Psychiatric

Frequency not reported: Anxiety, insomnia, depression

Renal

Frequency not reported: Decreased renal clearance of creatinine

Respiratory

Frequency not reported: Pleural effusion, dyspnea

Frequently asked questions

• What type of drug is Xerava?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer