VPRIV Side Effects
Generic name: velaglucerase alfa
Note: This document contains side effect information about velaglucerase alfa. Some of the dosage forms listed on this page may not apply to the brand name VPRIV.
Some side effects of VPRIV may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to velaglucerase alfa: intravenous powder for solution
Along with its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking velaglucerase alfa:More common
- Body aches or pain
- difficulty with breathing
- ear congestion
- facial swelling
- fever or chills
- loss of voice
- nasal congestion
- nausea or vomiting
- runny nose
- shortness of breath
- skin rash
- sore throat
- unusual tiredness or weakness
- Blurred vision
- bone pain
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- pain, itching, burning, swelling, or a lump under your skin where the needle is placed
- pounding in the ears
- slow or fast heartbeat
Some side effects of velaglucerase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach pain
- back pain
- joint pain
- lack or loss of strength
- Feeling of warmth
- hives or welts
- redness of the skin
- redness of the face, neck, arms, and occasionally, upper chest
For Healthcare Professionals
Applies to velaglucerase alfa: intravenous powder for injection
General side effects including infusion-related reaction (up to 51.9%), pyrexia (up to 22.2%), and asthenia/fatigue (up to 13%) have been reported.
Infusion-related reactions include any event considered related to and occurring within up to 24 hours of velaglucerase alfa infusion.
Nervous system side effects including headache (up to 35.2%) and dizziness (up to 22.2%) have been reported.
Gastrointestinal side effects including abdominal pain (up to 18.5%) and nausea (up to 10%) have been reported.
Musculoskeletal side effects including back pain (up to 17.5%) and knee pain (up to 14.8%) have been reported.
Hematologic side effects including prolonged activated partial thromboplastin time (up to 11.1%) has been reported.
More VPRIV resources
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