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VPRIV Side Effects

Generic Name: velaglucerase alfa

Note: This page contains side effects data for the generic drug velaglucerase alfa. It is possible that some of the dosage forms included below may not apply to the brand name VPRIV.

It is possible that some side effects of VPRIV may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for solution

As well as its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking velaglucerase alfa, check with your doctor or nurse immediately:

More common
  • Body aches or pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • runny nose
  • shortness of breath
  • skin rash
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Blurred vision
  • bone pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nervousness
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • pounding in the ears
  • slow or fast heartbeat
  • sweating

Some velaglucerase alfa side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abdominal or stomach pain
  • back pain
  • joint pain
  • lack or loss of strength
Less common
  • Feeling of warmth
  • hives or welts
  • itching
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection

General

The most common side effects reported in at least 10% of patients were hypersensitivity reactions, headache, dizziness, abdominal pain, nausea, back pain, joint pain, prolonged activated partial thromboplastin time, fatigue/asthenia, and pyrexia. The most serious side effects reported were hypersensitivity reactions.

Hypersensitivity

The term "hypersensitivity reaction" includes any event related to and occurring within up to 24 hours of velaglucerase alfa (the active ingredient contained in VPRIV) infusion, including 1 case of anaphylaxis.

Very common (10% or more): Hypersensitivity reaction (up to 52%)
Frequency not reported: Anaphylaxis (at least 1 case)

Nervous system

Very common (10% or more): Headache (up to 35%), dizziness (up to 22%)

Other

Very common (10% or more): Pyrexia (up to 22%), asthenia/fatigue (13%)
Common (1% to 10%): Flushing (at least 2%)

Gastrointestinal

Very common (10% or more): Abdominal pain (up to 19%)
Common (1% to 10%): Nausea (up to 10%)

Musculoskeletal

Very common (10% or more): Back pain (up to 18%), knee joint pain (up to 15%)
Common (1% to 10%): Bone pain (at least 2%)

Hematologic

Very common (10% or more): Prolonged activated partial thromboplastin time (up to 11%)

Cardiovascular

Common (1% to 10%): Tachycardia (at least 2%), hypertension (at least 2%), hypotension (at least 2%)

Dermatologic

Common (1% to 10%): Rash (at least 2%), urticaria (at least 2%)

Immunologic

Common (1% to 10%): IgG antibodies to velaglucerase alfa (the active ingredient contained in VPRIV) (1.9%)
Frequency not reported: Potential for immunogenicity

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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