Medication Guide App

VPRIV Side Effects

Generic Name: velaglucerase alfa

Note: This page contains side effects data for the generic drug velaglucerase alfa. It is possible that some of the dosage forms included below may not apply to the brand name VPRIV.

It is possible that some side effects of VPRIV may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for solution

As well as its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking velaglucerase alfa, check with your doctor or nurse immediately:

More common
  • Body aches or pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • runny nose
  • shortness of breath
  • skin rash
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Blurred vision
  • bone pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nervousness
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • pounding in the ears
  • slow or fast heartbeat
  • sweating

Some velaglucerase alfa side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abdominal or stomach pain
  • back pain
  • joint pain
  • lack or loss of strength
Less common
  • Feeling of warmth
  • hives or welts
  • itching
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection


The most common side effects reported in at least 10% of patients were hypersensitivity reactions, headache, dizziness, abdominal pain, nausea, back pain, joint pain, prolonged activated partial thromboplastin time, fatigue/asthenia, and pyrexia. The most serious side effects reported were hypersensitivity reactions.[Ref]


The term "hypersensitivity reaction" includes any event related to and occurring within up to 24 hours of velaglucerase alfa (the active ingredient contained in VPRIV) infusion, including 1 case of anaphylaxis.[Ref]

Very common (10% or more): Hypersensitivity reaction (up to 52%)
Frequency not reported: Anaphylaxis (at least 1 case)[Ref]

Nervous system

Very common (10% or more): Headache (up to 35%), dizziness (up to 22%)[Ref]


Very common (10% or more): Pyrexia (up to 22%), asthenia/fatigue (13%)
Common (1% to 10%): Flushing (at least 2%)[Ref]


Very common (10% or more): Abdominal pain (up to 19%)
Common (1% to 10%): Nausea (up to 10%)[Ref]


Very common (10% or more): Back pain (up to 18%), knee joint pain (up to 15%)
Common (1% to 10%): Bone pain (at least 2%)[Ref]


Very common (10% or more): Prolonged activated partial thromboplastin time (up to 11%)[Ref]


Common (1% to 10%): Tachycardia (at least 2%), hypertension (at least 2%), hypotension (at least 2%)[Ref]


Common (1% to 10%): Rash (at least 2%), urticaria (at least 2%)[Ref]


Common (1% to 10%): IgG antibodies to velaglucerase alfa (the active ingredient contained in VPRIV) (1.9%)
Frequency not reported: Potential for immunogenicity[Ref]


1. "Product Information. VPRIV (velaglucerase alfa)." Shire US Inc, Florence, KY.

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