VPRIV Side Effects

Generic Name: velaglucerase alfa

Note: This document contains side effect information about velaglucerase alfa. Some of the dosage forms listed on this page may not apply to the brand name VPRIV.

Some side effects of VPRIV may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for solution

Along with its needed effects, velaglucerase alfa (the active ingredient contained in VPRIV) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking velaglucerase alfa:

More common
  • Body aches or pain
  • cough
  • difficulty with breathing
  • dizziness
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • loss of voice
  • nasal congestion
  • nausea or vomiting
  • runny nose
  • shortness of breath
  • skin rash
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Blurred vision
  • bone pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • nervousness
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • pounding in the ears
  • slow or fast heartbeat
  • sweating

Some side effects of velaglucerase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • back pain
  • joint pain
  • lack or loss of strength
Less common
  • Feeling of warmth
  • hives or welts
  • itching
  • redness of the skin
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection

General

The most common side effects reported in at least 10% of patients were hypersensitivity reactions, headache, dizziness, abdominal pain, nausea, back pain, joint pain, prolonged activated partial thromboplastin time, fatigue/asthenia, and pyrexia. The most serious side effects reported were hypersensitivity reactions.

Hypersensitivity

The term "hypersensitivity reaction" includes any event related to and occurring within up to 24 hours of velaglucerase alfa (the active ingredient contained in VPRIV) infusion, including 1 case of anaphylaxis.

Very common (10% or more): Hypersensitivity reaction (up to 52%)
Frequency not reported: Anaphylaxis (at least 1 case)

Nervous system

Very common (10% or more): Headache (up to 35%), dizziness (up to 22%)

Other

Very common (10% or more): Pyrexia (up to 22%), asthenia/fatigue (13%)
Common (1% to 10%): Flushing (at least 2%)

Gastrointestinal

Very common (10% or more): Abdominal pain (up to 19%)
Common (1% to 10%): Nausea (up to 10%)

Musculoskeletal

Very common (10% or more): Back pain (up to 18%), knee joint pain (up to 15%)
Common (1% to 10%): Bone pain (at least 2%)

Hematologic

Very common (10% or more): Prolonged activated partial thromboplastin time (up to 11%)

Cardiovascular

Common (1% to 10%): Tachycardia (at least 2%), hypertension (at least 2%), hypotension (at least 2%)

Dermatologic

Common (1% to 10%): Rash (at least 2%), urticaria (at least 2%)

Immunologic

Common (1% to 10%): IgG antibodies to velaglucerase alfa (the active ingredient contained in VPRIV) (1.9%)
Frequency not reported: Potential for immunogenicity

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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