VPRIV Side Effects

Generic name: velaglucerase alfa

Note: This document contains side effect information about velaglucerase alfa. Some of the dosage forms listed on this page may not apply to the brand name VPRIV.

Some side effects of VPRIV may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to velaglucerase alfa: intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking velaglucerase alfa (the active ingredient contained in VPRIV) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people receiving a velaglucerase alfa injection have had a reaction to the infusion (when the medicine is injected into the vein). Most infusion reactions have been mild. However, tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, short of breath, or have a fast heartbeat, chest tightness, or trouble breathing during the injection.

Less serious side effects of velaglucerase alfa may include:

• headache;

• low fever;

• dizziness, tired feeling;

• nausea, stomach pain;

• knee pain, back pain; or

• cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to velaglucerase alfa: intravenous powder for injection

General

General side effects including infusion-related reaction (up to 51.9%), pyrexia (up to 22.2%), and asthenia/fatigue (up to 13%) have been reported.

Infusion-related reactions include any event considered related to and occurring within up to 24 hours of velaglucerase alfa infusion.

Nervous system

Nervous system side effects including headache (up to 35.2%) and dizziness (up to 22.2%) have been reported.

Gastrointestinal

Gastrointestinal side effects including abdominal pain (up to 18.5%) and nausea (up to 10%) have been reported.

Musculoskeletal

Musculoskeletal side effects including back pain (up to 17.5%) and knee pain (up to 14.8%) have been reported.

Hematologic

Hematologic side effects including prolonged activated partial thromboplastin time (up to 11.1%) has been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.