Valchlor Side Effects

Generic name: mechlorethamine topical

Medically reviewed by Drugs.com. Last updated on Jul 30, 2023.

Note: This document contains side effect information about mechlorethamine topical. Some dosage forms listed on this page may not apply to the brand name Valchlor.

Applies to mechlorethamine topical: topical application gel/jelly.

Serious side effects of Valchlor

Along with its needed effects, mechlorethamine topical (the active ingredient contained in Valchlor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mechlorethamine topical:

More common

Blistering, crusting, irritation, itching, or reddening of the skin
cracked, dry, scaly skin
pain, swelling, tenderness, or warmth on the skin

Other side effects of Valchlor

Some side effects of mechlorethamine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Darkening of the skin

For Healthcare Professionals

Applies to mechlorethamine topical: topical gel.

Dermatologic

Very common (10% or more): Dermatitis (56%), pruritus (20%), bacterial skin infection (11%)

Common (1% to 10%): Skin ulceration or blistering, skin hyperpigmentation^[Ref]

Hematologic

Very common (10% or more): Reductions in hemoglobin, neutrophil count, or platelet count (13%)^[Ref]

Oncologic

Common (1% to 10%): Nonmelanoma skin cancer^[Ref]

Ocular

Frequency not reported: Eye pain, burns, inflammation, photophobia, blurred vision, blindness, irreversible anterior eye injury^[Ref]

General

The most common adverse reactions (5% or greater) are dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, and hyperpigmentation^[Ref]