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Urolene Blue Side Effects

Generic Name: methylene blue

Note: This page contains side effects data for the generic drug methylene blue. It is possible that some of the dosage forms included below may not apply to the brand name Urolene Blue.

For the Consumer

Applies to methylene blue: intravenous solution

As well as its needed effects, methylene blue (the active ingredient contained in Urolene Blue) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking methylene blue, check with your doctor or nurse immediately:

If any of the following symptoms of overdose occur while taking methylene blue, get emergency help immediately:

Symptoms of overdose:
  • Anxiety
  • back pain
  • bluish fingernails, lips, or skin
  • chest pain
  • chills
  • confusion
  • difficulty with breathing
  • dizziness
  • headache
  • leg pain
  • nausea and vomiting
  • severe sweating
  • stomach pain
  • trembling
  • unusual tiredness or weakness

Severity: Minor

Some methylene blue side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Greenish blue to blue discoloration of the urine and stools
Less common:
  • Diarrhea
  • nausea and vomiting
  • painful urination or increased need to urinate

For Healthcare Professionals

Applies to methylene blue: compounding powder, injectable solution, oral tablet


Cardiovascular side effects have included hypertension and precordial pain.[Ref]


1. "Product Information. Methylene Blue (methylene blue)." American Regent Laboratories Inc, Shirley, NY.

It is possible that some side effects of Urolene Blue may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.