Urolene Blue Side Effects

Generic Name: methylene blue

Note: This document contains side effect information about methylene blue. Some of the dosage forms listed on this page may not apply to the brand name Urolene Blue.

Some side effects of Urolene Blue may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to methylene blue: intravenous solution

Along with its needed effects, methylene blue (the active ingredient contained in Urolene Blue) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking methylene blue:

Get emergency help immediately if any of the following symptoms of overdose occur while taking methylene blue:

Symptoms of overdose
  • Anxiety
  • back pain
  • bluish fingernails, lips, or skin
  • chest pain
  • chills
  • confusion
  • difficulty with breathing
  • dizziness
  • headache
  • leg pain
  • nausea and vomiting
  • severe sweating
  • stomach pain
  • trembling
  • unusual tiredness or weakness

Some side effects of methylene blue may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Greenish blue to blue discoloration of the urine and stools
Less common
  • Diarrhea
  • nausea and vomiting
  • painful urination or increased need to urinate

For Healthcare Professionals

Applies to methylene blue: compounding powder, injectable solution, oral tablet


Cardiovascular side effects have included hypertension and precordial pain.

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