Twinrix Side Effects

Generic name: hepatitis a adult vaccine / hepatitis b adult vaccine

Note: This document contains side effect information about hepatitis a adult vaccine / hepatitis b adult vaccine. Some of the dosage forms listed on this page may not apply to the brand name Twinrix.

Some side effects of Twinrix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to hepatitis a adult vaccine / hepatitis b adult vaccine: intramuscular suspension

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with hepatitis A or B is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction while taking hepatitis a adult vaccine / hepatitis b adult vaccine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• fast or pounding heartbeats; or

• easy bruising or bleeding.

Less serious side effects include:

• redness, pain, tenderness, swelling, or a hard lump where the shot was given;

• headache, tired feeling;

• mild fever;

• runny or stuffy nose, sore throat, other cold symptoms; or

• nausea, vomiting, loss of appetite, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hepatitis a adult vaccine / hepatitis b adult vaccine: intramuscular suspension

General

Hepatitis A-hepatitis B vaccine is generally well-tolerated. Most side effects were mild, self-limiting, and of short duration (less than 48 hours).

Local

Local side effects have included soreness, redness, swelling, induration, pruritus, and ecchymosis at the injection site.

Other

Other side effects have included headache, fatigue, fever, sweating, weakness, flushing, influenza-like symptoms, tingling, tinnitus, and earache.

Cardiovascular

Cardiovascular side effects have included syncope, hypotension, tachycardia, and palpitations.

Dermatologic

Dermatologic side effects have included rash, urticaria, petechiae, erythema, hyperhidrosis, angioedema, eczema, herpes zoster, erythema nodosum, and alopecia.

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, abdominal pain, anorexia, constipation, dysgeusia, and dyspepsia.

Hematologic

Hematologic side effects have included lymphadenopathy and thrombocytopenia.

Hepatic

Hepatic side effects have included jaundice, hepatitis, and abnormal liver function tests.

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis, anaphylactoid reactions, erythema multiforme, Stevens-Johnson syndrome, angioedema, arthritis, and serum-sickness-like syndrome (arthralgia, arthritis, fever, urticaria, erythema multiforme, ecchymoses, and erythema nodosum).

Musculoskeletal

Musculoskeletal side effects have included arthralgia, myalgia, back pain, and creatine phosphokinase elevations.

Nervous system

Nervous system side effects have included migraine, paresthesia, vertigo, somnolence, insomnia, irritability, agitation, dizziness, hypertonic episode, convulsions, paresis, encephalopathy, neuropathy, myelitis, Guillain-Barre syndrome, multiple sclerosis, Bell's palsy, and transverse myelitis.

Ocular

Ocular side effects have included photophobia, optic neuritis, conjunctivitis, keratitis, and visual disturbances.

Respiratory

Respiratory side effects have included upper respiratory tract infections, dyspnea, bronchospasm, and asthma-like symptoms.

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