Twin-K Side Effects
Generic name: potassium citrate
Note: This document contains side effect information about potassium citrate. Some of the dosage forms listed on this page may not apply to the brand name Twin-K.
Some side effects of Twin-K may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to potassium citrate: oral patch extended release, oral solution, oral tablet, oral tablet extended release
Along with its needed effects, potassium citrate (the active ingredient contained in Twin-K) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking potassium citrate:Incidence not known
- Abdominal or stomach discomfort
Get emergency help immediately if any of the following symptoms of overdose occur while taking potassium citrate:Symptoms of overdose
- Abdominal or stomach pain
- difficult breathing
- irregular heartbeat
- numbness or tingling in the hands, feet, or lips
- shortness of breath
- weakness or heaviness of the legs
For Healthcare Professionals
Applies to potassium citrate: compounding powder, oral liquid, oral tablet extended release
Metabolic side effects have been reported rarely. Hyperkalemia may cause life-threatening cardiac arrhythmias, and can occur even when renal function is normal. Patients should not use potassium-rich salt substitutes without the advice of their healthcare professional during potassium citrate (the active ingredient contained in Twin-K) therapy. Long-term therapy can result in metabolic alkalosis.
Signs of hyperkalemia include muscle weakness (including frank skeletal muscle and diaphragm paralysis), peaked T waves on the ECG, and cardiac arrhythmias.
Gastrointestinal (GI) side effects have been reported the most frequently. These have included nausea, vomiting, and epigastric or abdominal pain (in 3% to 17% of patients). GI side effects may be lessened by taking the drug with meals.
There are numerous reports of GI ulceration and rare reports of gastric or small bowel obstruction associated with the use of solid potassium salt preparations. Patients at higher risk of GI lesions include the elderly and patients with scleroderma, diabetes mellitus, mitral valve replacement, cardiomegaly, esophageal stricture, or impaired GI motility or diverticulae.
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