Potassium citrate Pregnancy and Breast Feeding Warnings
Potassium citrate is also known as: Twin-K, Urocit-K
Overview
If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Potassium Citrate while you are pregnant. It is not known if Potassium Citrate is found in breast milk. If you are or will be breast-feeding while you use Potassium Citrate , check with your doctor. Discuss any possible risks to your baby.
Potassium citrate Pregnancy Warnings
Potassium citrate has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Some experts consider potassium replacement to be indicated and relatively safe for pregnant women. Potassium citrate is only recommended for use during pregnancy when benefit outweighs risk.
Potassium citrate is a naturally-occurring molecule. If K+ products are necessary in a pregnant patient, close attention to the maternal serum K+ concentrations is recommended due to the risk of maternal and fetal cardiac arrhythmias associated with abnormal serum K+ concentrations. Data from the Michigan Medicaid Birth Defects Study, in which 104,339 deliveries between 1980 to 1983 and 229,101 deliveries between 1985 to 1992 were retrospectively studied, reveal conflicting data (written communication, Frank Rosa, MD, Food and Drug Administration, 1994). In these two studies, 116 and 166 women, respectively, were exposed to a related molecule, potassium chloride (KCl), during gestation. Of the 116 women from the 1980 to 1983 period, 14 defects were observed (7 were expected), of which 4 were cardiovascular abnormalities (1 was expected). These data are consistent with an association between KCl and birth defects. Of the 166 women from the 1985 to 1992 period, 8 defects were observed (7 were expected). There were no cases of cardiovascular abnormalities. There were no cases of cleft palate from either period studied. These data do not provide evidence of an association between KCl and birth defects.
Potassium citrate Lactation Warnings
Human milk is naturally low in potassium, averaging approximately 13 mEq/L. There are no reports of adverse effects associated with the use of potassium salts in the nursing infant, and they are considered unlikely.
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