Tolazamide Side Effects
Some side effects of tolazamide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to tolazamide: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking tolazamide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Hypoglycemia, or low blood sugar, is the most common side effect of tolazamide. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.
Call your doctor at once if you have a serious side effect such as:
chest pain, shortness of breath, feeling like you might pass out;
easy bruising or bleeding, unusual weakness; or
extreme thirst with headache, nausea, vomiting, and weakness.
Less serious side effects of tolazamide may include:
dizziness or weakness;
headache, tired feeling;
mild nausea, heartburn, full feeling;
skin rash, redness, or itching; or
increased skin sensitivity to sunlight.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to tolazamide: oral tablet
Gastrointestinal side effects have included nausea, epigastric fullness, and heart burn. These effects tend to be dose-related and may resolve upon a reduction in dose.
Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions. Porphyria cutanea tarda and photosensitivity reactions have been reported with the use of sulfonylureas.
Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.
Metabolic side effects have included hypoglycemia and hyponatremia. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with other sulfonylureas.
Nervous system side effects have included dizziness and headache.
General side effects have included weakness, fatigue, vertigo, and malaise.
A 54-year-old woman with self-limiting cholestatic jaundice after treatment with chlorpropamide experienced a recurrence of jaundice following subsequent treatment with tolazamide. Discontinuation of tolazamide resulted in resolution of the jaundice, indicating a possible hepatic cross-sensitivity with chlorpropamide.
Hepatic side effects have rarely included cholestatic jaundice.
More tolazamide resources
- tolazamide MedFacts Consumer Leaflet (Wolters Kluwer)
- tolazamide Concise Consumer Information (Cerner Multum)
- tolazamide Advanced Consumer (Micromedex) - Includes Dosage Information
- Tolazamide Prescribing Information (FDA)
- Tolazamide Professional Patient Advice (Wolters Kluwer)
- Tolazamide Monograph (AHFS DI)
- Tolinase Prescribing Information (FDA)
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