Titralac Side Effects

Generic Name: calcium carbonate

Please note - some side effects for Titralac may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Titralac - for the Consumer

Titralac

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Titralac:

Constipation; diarrhea.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); headache; increased stomach pain; increased urination; loss of appetite; muscle weakness; nausea; slow reflexes; vomiting; weakness.

Titralac Plus Chewable Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Titralac Plus Chewable Tablets:

Constipation; diarrhea.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of appetite; muscle weakness; nausea; slow reflexes; vomiting.

Titralac Plus Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Titralac Plus Suspension:

Constipation; diarrhea.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; frequent urination; increased stomach pain; irritability; loss of appetite; muscle weakness; nausea; slow reflexes; vomiting, including vomit that looks like coffee grounds; weakness.

Side Effects by Body System

Gastrointestinal

Rebound hyperacidity has been associated with calcium salt antacids. This side effect does not appear to be due to the acid buffering capacity of calcium carbonate, but is a consequence of a specific action of calcium on the parietal cell.

Rare cases of calcium carbonate gallstones have been reported in the pediatric literature.

Gastrointestinal side effects have included rebound hyperacidity, constipation (6% to 37%) and gallstones (rarely).

Metabolic

Prolonged ingestion of large amounts of calcium carbonate and other sources of exogenous calcium can rarely result in the "milk alkali syndrome" and calcinosis. The milk alkali syndrome is characterized by the triad of hypercalcemia, metabolic alkalosis, and renal insufficiency.

Metabolic side effects have rarely included hypercalcemia and hypophosphatemia. Hypercalcemia may be more likely and more severe in patients with renal dysfunction. In patients on chronic dialysis, hypercalcemia may also result from excessive calcium in the dialysate, vitamin D intoxication, or severe secondary hyperparathyroidism. Other metabolic side effects have rarely included "mild alkali syndrome", calcinosis, and irreversible renal damage.

Renal

Renal side effects have included renal failure, formation of renal calcium and a single case report of a calcium carbonate and calcium phosphate-filled renal cyst.

The renal failure that accompanies hypercalcemia and alkalosis in the milk alkali syndrome is usually transient.

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