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Teriparatide Side Effects

In Summary

Commonly reported side effects of teriparatide include: pain, arthralgia, and rhinitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to teriparatide: subcutaneous solution

As well as its needed effects, teriparatide may cause unwanted side effects that require medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as bone cancer. Discuss these possible effects with your doctor.

Severity: Major

If any of the following side effects occur while taking teriparatide, check with your doctor immediately:

More common:
  • Abdominal pain
  • confusion
  • constipation
  • depression
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • nausea
  • thirst
  • unusual tiredness
  • vomiting
  • weight loss
Less common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • cough
  • difficult or labored breathing
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • nausea
  • shortness of breath
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • wheezing
Incidence not known:
  • Hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling or puffiness of the mouth and face

Severity: Minor

Some teriparatide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Acid or sour stomach
  • belching
  • blurred vision
  • body aches or pain
  • congestion
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • muscle spasm
  • nervousness
  • pain in the joints
  • pounding in the ears
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Less common:
  • Abdominal or stomach cramps
  • back pain
  • discomfort
  • discouragement
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • indigestion
  • irritability
  • lack of appetite
  • leg cramps
  • loss of interest or pleasure
  • neck pain
  • rash
  • sensation of spinning
  • sleeplessness
  • swollen mouth and tongue
  • tiredness
  • tooth disorder
  • trouble concentrating
  • trouble sleeping
  • unpleasant taste
  • urge to have bowel movement
Rare:
  • Pain at the place of injection during or following the injection
  • tingling feeling in the hands and feet
  • urge for bowel movement
Incidence not known:
  • Bruising at the injection site
  • flushing
  • minor bleeding at the injection site
  • unusually warm skin

For Healthcare Professionals

Applies to teriparatide: subcutaneous device

Cardiovascular

Common (1% to 10%): Hypotension, hypertension, palpitations, chest pain, angina pectoris
Uncommon (0.1% to 1%): Tachycardia, cardiac murmur
Frequency not reported: Peripheral edema[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, hiatus hernia, gastro-esophageal reflux disease, constipation, diarrhea, dyspepsia, gastrointestinal disorder, tooth disorder
Uncommon (0.1% to 1%): Hemorrhoids[Ref]

Musculoskeletal

Very common (10% or more): Pain in limb, arthralgia (10%)
Common (1% to 10%): Muscle cramps, neck pain, leg cramps
Uncommon (0.1% to 1%): Myalgia, arthralgia, back cramp/pain[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, sciatica, syncope[Ref]

Respiratory

Common (1% to 10%): Dyspnea, rhinitis, cough increased, pharyngitis, pneumonia
Uncommon (0.1% to 1%): Emphysema[Ref]

Dermatologic

Common (1% to 10%): Rash, sweating increased[Ref]

Endocrine

Frequency not reported: Transient hypoparathyroidism[Ref]

Hypersensitivity

Rare (less than 0.1%): Anaphylaxis, possible allergic events soon after injection (e.g., acute dyspnea, oro/facial edema, generalized urticaria, chest pain, edema (mainly peripheral)
Postmarketing reports: Drug hypersensitivity, angioedema, urticaria[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Local

Common (1% to 10%): Mild and transient injection site events (e.g., pain, swelling, erythema, localized bruising, pruritus, minor bleeding at injection site)
Uncommon (0.1% to 1%): Injection site erythema, injection site reaction[Ref]

Metabolic

Common (1% to 10%): Hypercholesterolemia
Uncommon (0.1% to 1%): Hypercalcemia (greater than 2.76 mmol/L), hyperuricemia, weight gain, alkaline phosphatase increase[Ref]

Other

Very common (10% or more): Pain (21%)
Common (1% to 10%): Vertigo, fatigue, asthenia, syncope[Ref]

Psychiatric

Common (1% to 10%): Depression, insomnia[Ref]

Renal

Uncommon (0.1% to 1%): Urinary incontinence, polyuria, micturition urgency, nephrolithiasis
Rare (less than 0.1%): Renal failure/impairment[Ref]

Oncologic

Frequency not reported: Osteosarcoma[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Forteo (teriparatide)." Lilly, Eli and Company, Indianapolis, IN.

It is possible that some side effects of teriparatide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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