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Teriparatide Side Effects

It is possible that some side effects of teriparatide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to teriparatide: subcutaneous solution

As well as its needed effects, teriparatide may cause unwanted side effects that require medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as bone cancer. Discuss these possible effects with your doctor.

If any of the following side effects occur while taking teriparatide, check with your doctor immediately:

More common
  • Abdominal pain
  • confusion
  • constipation
  • depression
  • dry mouth
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • nausea
  • thirst
  • unusual tiredness
  • vomiting
  • weight loss
Less common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • cough
  • difficult or labored breathing
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • nausea
  • shortness of breath
  • sneezing
  • sore throat
  • sweating
  • tightness in the chest
  • wheezing
Incidence not known
  • Hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling or puffiness of the mouth and face

Some teriparatide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Acid or sour stomach
  • belching
  • blurred vision
  • body aches or pain
  • congestion
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • heartburn
  • hoarseness
  • indigestion
  • lack or loss of strength
  • muscle pain or stiffness
  • muscle spasm
  • nervousness
  • pain in the joints
  • pounding in the ears
  • runny nose
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
Less common
  • Abdominal or stomach cramps
  • back pain
  • discomfort
  • discouragement
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • indigestion
  • irritability
  • lack of appetite
  • leg cramps
  • loss of interest or pleasure
  • neck pain
  • rash
  • sensation of spinning
  • sleeplessness
  • swollen mouth and tongue
  • tiredness
  • tooth disorder
  • trouble concentrating
  • trouble sleeping
  • unpleasant taste
  • urge to have bowel movement
  • Pain at the place of injection during or following the injection
  • tingling feeling in the hands and feet
  • urge for bowel movement
Incidence not known
  • Bruising at the injection site
  • flushing
  • minor bleeding at the injection site
  • unusually warm skin

For Healthcare Professionals

Applies to teriparatide: subcutaneous device


Cardiovascular side effects have included hypertension, angina pectoris, and syncope.[Ref]


Gastrointestinal side effects have included nausea, constipation, diarrhea, and vomiting.[Ref]


Musculoskeletal side effects have included arthralgias and leg cramps. Postmarketing reports have included muscle spasms, such as of the leg or back (between 1 and 10 patients per 100 patients treated).[Ref]

Nervous system

Nervous system side effects have included dizziness, depression, insomnia, and vertigo.[Ref]


Respiratory system side effects have included rhinitis, increased cough, pharyngitis, and pneumonia.[Ref]


Dermatologic side effects have included rash and sweating.[Ref]


General side effects have included pain, headache, asthenia, and neck pain. Pain at the injection site has also be reported.[Ref]


Endocrine side effects have included transient hypoparathyroidism.[Ref]


Hypersensitivity side effects have included postmarketing reports of possible allergic events soon after injection: acute dyspnea, oro/facial edema, generalized urticaria, chest pain (less than 1 in 1000 patients treated).[Ref]


1. "Product Information. Forteo (teriparatide)." Lilly, Eli and Company, Indianapolis, IN.

2. Lindsay R, Nieves J, Formica C, et al. "Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis." Lancet 350 (1997): 550-5

3. Audran M, Basle MF, Defontaine A, et al. "Transient hypoparathyroidism induced by synthetic human parathyroid hormone-(1-34) treatment." J Clin Endocrinol Metab 64 (1987): 937-43

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