Temodar Side Effects
Generic Name: temozolomide
Note: This document contains side effect information about temozolomide. Some of the dosage forms listed on this page may not apply to the brand name Temodar.
Some side effects of Temodar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to temozolomide: oral capsule
Other dosage forms:
Along with its needed effects, temozolomide (the active ingredient contained in Temodar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
Check with your doctor immediately if any of the following side effects occur while taking temozolomide:Less common or rare
- black, tarry stools
- blood in the urine or stools
- convulsions (seizures)
- cough or hoarseness
- fever or chills
- lower back or side pain
- muscle weakness or paralysis on one or both sides of the body
- painful or difficult urination
- pinpoint red spots on the skin
- swelling of the feet or lower legs
- unusual bleeding or bruising
- Blistering, peeling, or loosening of the skin
- chest pain
- difficulty swallowing
- fast heartbeat
- fever or chills
- joint or muscle pain
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- skin rash
- sore throat
- tightness in the chest
- troubled breathing
- unusual tiredness or weakness
Some side effects of temozolomide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- nausea and vomiting
- unusual tiredness or weakness
- Abdominal or stomach pain
- blurred or double vision
- breast pain (in females)
- burning or prickling feeling on the skin
- difficulty with speaking
- loss of appetite
- loss of muscle coordination
- mental depression
- muscle pain
- runny or stuffy nose
- skin rash or itching
- sore throat
- trouble with sleeping
- unusual weight gain
- urinary incontinence or increased urge to urinate
For Healthcare Professionals
Applies to temozolomide: intravenous powder for injection, oral capsule
Gastrointestinal effects including nausea (53%), vomiting (42%), constipation (33%), diarrhea (16%), abdominal pain (9%), and anorexia (9%) have been reported.
General effects including headache (41%), fatigue (34%), asthenia (13%), fever (13%), and back pain (8%) have been reported.
Nervous system effects including convulsions (23%), hemiparesis (18%), dizziness (12%), abnormal coordination (11%) amnesia (10%), insomnia (10%), paresthesia (9%), somnolence (9%), paresis (8%), urinary incontinence (8%), ataxia (8%), dysphasia (7%), local convulsions (6%), abnormal gait (6%), and confusion (5%) have been reported.
Cardiovascular effects including peripheral edema (11%) have been reported.
Other effects including viral infection (11%) have been reported.
Endocrine effects including adrenal hypercorticism (8%) have been reported.
Genitourinary effects including urinary tract infection (8%), increased frequency of micturition (6%) and female breast pain (6%) have been reported.
Respiratory effects including upper respiratory tract infection (8%), pharyngitis (8%), sinusitis (6%), and coughing (5%) have been reported. Cases of interstitial pneumonitis/pneumonitis, alveolitis, and pulmonary fibrosis have been reported.
Dermatologic effects including rash (8%) and pruritus (8%) have been reported.
A case of diffuse erythematous skin rash that progressed to an extensive full body desquamative skin rash has been reported. Even though temozolomide was permanently discontinued, the patient continued to experience the rash on a long-term basis with periodic exacerbations.
Psychiatric effects including anxiety (7%) and depression (6%) have been reported.
Metabolic effects including weight gain (5%) have been reported.
Musculoskeletal effects including myalgia (5%) have been reported.
Ocular effects including diplopia (5%) and abnormal vision (5%) have been reported.
Immunologic side effects including rare cases of opportunistic infections such as Pneumocystis carinii pneumonia have been reported.
Oncologic side effects such as very rare cases of myelodysplastic syndrome and secondary malignancies, including leukemia and newly diagnosed glioblastoma multiforme have been reported.
Hematologic side effects have been reported very rarely including prolonged pancytopenia (which may result in aplastic anemia).
Postmarketing hepatic side effects have included elevated liver enzymes, hyperbillirubinemia, cholestasis, and hepatitis.
More about Temodar (temozolomide)
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