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Tazicef Side Effects

Generic Name: ceftazidime

Note: This page contains side effects data for the generic drug ceftazidime. It is possible that some of the dosage forms included below may not apply to the brand name Tazicef.

It is possible that some side effects of Tazicef may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ceftazidime: injection powder for solution

As well as its needed effects, ceftazidime (the active ingredient contained in Tazicef) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ceftazidime, check with your doctor or nurse immediately:

Less common
  • Abdominal or stomach cramps or tenderness
  • bloating
  • bluish color
  • changes in skin color
  • diarrhea, watery and severe, which may also be bloody
  • fever
  • increased thirst
  • itching of the vagina or genital area
  • nausea or vomiting
  • pain
  • pain during sexual intercourse
  • swelling at the site of injection
  • swelling of the foot or leg
  • tenderness
  • thick, white vaginal discharge with no odor or with a mild odor
  • unusual tiredness or weakness
  • unusual weight loss
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash
Rare
  • Back, leg, or stomach pains
  • bleeding gums
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cough
  • dark urine
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • general body swelling
  • headache
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • nosebleeds
  • pale skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • sore throat
  • tightness in the chest
  • wheezing
  • yellowing of the eyes or skin
Incidence not known
  • Agitation
  • bloody or cloudy urine
  • blurred vision
  • change in consciousness
  • chest pain
  • clay-colored stools
  • confusion
  • coughing up blood
  • decreased frequency or amount of urine
  • diarrhea
  • difficult or painful urination
  • drowsiness
  • hallucinations
  • increased blood pressure
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • irritability
  • loss of consciousness
  • lower back or side pain
  • muscle twitching or jerking
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • rhythmic movement of the muscles
  • seizures
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck
  • sudden decrease in the amount of urine
  • swelling of the face, fingers, or lower legs
  • swollen or painful glands
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood
  • watery or bloody diarrhea
  • weight gain

Some ceftazidime side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Red streaks on the skin
  • swelling, tenderness, or pain at the injection site

For Healthcare Professionals

Applies to ceftazidime: injectable powder for injection, intravenous solution

Gastrointestinal

Gastrointestinal side effects reported in less than 2% of patients have included diarrhea, nausea, vomiting, abdominal pain, and pseudomembranous colitis. Oral candidiasis has been reported in less than 1% of patients. Clostridium difficile associated diarrhea has also been reported.

Discontinuation of ceftazidime may be necessary in severe, prolonged cases of diarrhea. Pseudomembranous colitis has been reported and should be considered if the patient does not respond to discontinuation of ceftazidime.

Hypersensitivity

Mild hypersensitivity reactions, such as rash, pruritus, and fever, have been reported and may necessitate discontinuation of ceftazidime (the active ingredient contained in Tazicef) A case of asthma induced by occupational exposure to ceftazidime has been reported.

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.

A patient with sensitization to aztreonam showed cross-reactivity to ceftazidime. Ceftazidime and aztreonam contain the same side chain, which may explain the cross-sensitivity.

Hypersensitivity reactions including rash, pruritus, and fever have been reported (2%). Cross reactions may occur in penicillin-allergic or aztreonam-allergic patients. Rarely, angioedema and anaphylactic reactions have occurred. Allergic reactions including cardiopulmonary arrest have been reported during postmarketing experience. Cephalosporin class antibiotics have been associated with Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis.

Renal

Although increases in serum creatinine do not necessarily indicate renal toxicity, urinary alanine aminopeptidase (AAP) has been found to be significantly increased in some patients and may indicate renal tubular cell damage.

Renal side effects have included transient increases in serum creatinine and BUN. Renal impairment has been reported during postmarketing experience. Cephalosporins as a class have been associated with renal dysfunction and toxic nephropathy.

Nervous system

Ceftazidime-induced encephalopathy has been reported in an 80-year-old man with underlying renal dysfunction. This patient became incoherent and tremulous and had severe myoclonic jerking in all extremities. Therapy was discontinued and symptoms abated, but reappeared on rechallenge with a smaller dose. Symptoms again resolved with discontinuation of ceftazidime (the active ingredient contained in Tazicef) therapy. Several other cases of ceftazidime-induced encephalopathy, and hallucinations have been reported. In most cases the patients had underlying renal dysfunction. Symptoms were similar and resolved with dose reduction or drug discontinuation.

Neurologic reactions may be more likely to occur in patients with underlying renal dysfunction. Close monitoring of neurologic status is recommended.

Nervous system side effects reported in less than 1% of patients have included headache, dizziness, paresthesia, and seizures. Encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia have occurred in patients with renal dysfunction who received unadjusted doses of ceftazidime.

Dermatologic

Dermatologic side effects have included pemphigus erythematosus and urticaria.

Local

Local side effects have included phlebitis and inflammation at the injection site.

Hematologic

Hematologic side effects have included transient eosinophilia, positive Coombs test without hemolysis, thrombocytosis, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, and lymphocytosis. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, prolonged prothrombin time, hemorrhage, neutropenia, pancytopenia, and agranulocytosis.

Other transient hematologic effects, such as thrombocytopenia, thrombocytosis, and leukopenia, have been observed less frequently.

Hepatic

Hepatic side effects have included transient increases in AST, ALT, GGT, and alkaline phosphatase. These elevations generally resolve after discontinuation of therapy. Hyperbilirubinemia and jaundice have been reported during postmarketing experience. Cephalosporins as a class have been associated with hepatic dysfunction, including cholestasis.

Genitourinary

Genitourinary side effects have included vaginitis and candidiasis. Cephalosporins as a class have been associated with false-positive tests for urine glucose.

Other

Other side effects have included superinfection.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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