Staphcillin Side Effects
Generic name: methicillin
Note: This document contains side effect information about methicillin. Some of the dosage forms listed on this page may not apply to the brand name Staphcillin.
Some side effects of Staphcillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Applies to methicillin: injectable powder for injection
Adverse hematologic effects occur in approximately 7% of treated patients and appear to be associated with higher doses given for long periods of time. Recovery generally occurs within one to two weeks.
Hematologic adverse effects reported with methicillin include neutropenia, leukopenia, and thrombocytopenia. Agranulocytosis has been reported rarely.
Methicillin (the active ingredient contained in Staphcillin) therapy has resulted in transient increases in liver function tests.
Hypersensitivity reactions to methicillin (the active ingredient contained in Staphcillin) include rash (2% to 6%), eosinophilia (up to 38%), pruritus, fever, chills, and myalgias. Methicillin is contraindicated in patients who are allergic to penicillin.
Local reactions include thrombophlebitis associated with intravenous administration, and pain at injection site if given intramuscularly.
Acute renal failure and interstitial nephritis have been associated with methicillin (the active ingredient contained in Staphcillin) therapy. These problems occur most frequently after prolonged therapy (longer than ten days). Acute interstitial nephritis may be accompanied by rash, fever, dysuria, proteinuria, eosinophilia, and hematuria.
The frequency of acute interstitial nephritis is higher with methicillin than other penicillinase-resistant penicillins and has been reported in up to 17% of patients. Acute renal failure generally occurs after ten days and with doses of methicillin greater than 200 mg/kg/day. Renal function slowly returns towards normal after discontinuation of methicillin, but irreversible decreases in renal function have been observed.
More Staphcillin resources
- Staphcillin Advanced Consumer (Micromedex) - Includes Dosage Information
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.