Rezzayo Side Effects

Generic name: rezafungin

Medically reviewed by Drugs.com. Last updated on Dec 29, 2023.

Note: This document contains side effect information about rezafungin. Some dosage forms listed on this page may not apply to the brand name Rezzayo.

Applies to rezafungin: intravenous powder for solution.

Serious side effects of Rezzayo

Along with its needed effects, rezafungin (the active ingredient contained in Rezzayo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking rezafungin:

More common

• Bone pain
• decreased urine
• drowsiness
• dry mouth
• irregular heartbeat
• loss of appetite
• mood or mental changes
• muscle pain, cramps, or spasms
• nausea or vomiting
• numbness or tingling in the hands, feet, or lips
• pale skin
• seizures
• trembling
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness

Less common

• Agitation
• black, tarry stools
• blood in the stools
• blood in the urine
• back pain
• chest tightness
• chills
• coma
• confusion
• coughing or vomiting blood
• decreased urine output
• depression
• difficulty swallowing
• dizziness
• feeling of warmth
• fever
• headache
• hostility
• irritability
• lethargy
• pain, numbness, or tingling of the hands, arms, legs, or feet
• persistent bleeding or oozing from puncture sites, mouth, or nose
• rash
• redness of the face, neck, arms and occasionally, upper chest
• stupor
• swelling of the face, fingers, hands, feet, ankles, or lower legs
• vomiting of blood or material that looks like coffee grounds
• weight gain

Incidence not known

• Dark urine
• increased sensitivity of skin to sunlight
• itching, hives, or welts
• pain or tenderness in the upper stomach
• pale stools
• redness or other discoloration of skin
• severe sunburn
• yellow eyes or skin

Other side effects of Rezzayo

Some side effects of rezafungin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Constipation
• diarrhea
• stomach pain

For Healthcare Professionals

Applies to rezafungin: intravenous powder for injection.

General

The most common adverse reactions occurring in 5% of patients or greater included hypokalemia, pyrexia, diarrhea, anemia, vomiting, nausea, hypomagnesemia, abdominal pain, constipation, and hypophosphatemia.^[Ref]

Dermatologic

Common (less than 5%): Erythema^[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (11%)

Common (1% to 10%): Vomiting, nausea, abdominal pain, constipation

Reported as less than 5%: Dysphagia, gastrointestinal hemorrhage^[Ref]

Hematologic

Very common (10% or more): Anemia (10%)

Common (less than 5%): Disseminated intravascular coagulation^[Ref]

Local

Common (less than 5%): Infusion-related reactions (including flushing, sensation of warmth, urticaria, nausea, and chest tightness)^[Ref]

Metabolic

Very common (10% or more): Hypokalemia (15%),

Common (1% to 10%): Hypomagnesemia, hypophosphatemia, fluid overload (less than 5%)^[Ref]

Other

Very common (10% or more): Pyrexia (12%)^[Ref]

Psychiatric

Common (less than 5%): Insomnia^[Ref]

Renal

Common (less than 5%): Acute kidney injury^[Ref]

Hepatic

Common (less than 5%): Abnormal liver tests (including hypertransaminasemia and increased gamma-glutamyltransferase)^[Ref]

Nervous system

Common (less than 5%): Headache, dizziness, peripheral neuropathy (including neuropathy

peripheral, polyneuropathy, and peroneal nerve palsy), tremors (occurring in second or third weeks of treatment)^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer