Promacta Side Effects

Generic Name: eltrombopag

Note: This document contains side effect information about eltrombopag. Some of the dosage forms listed on this page may not apply to the brand name Promacta.

Some side effects of Promacta may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to eltrombopag: oral tablet

Along with its needed effects, eltrombopag (the active ingredient contained in Promacta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eltrombopag:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • pale skin
  • rapid weight gain
  • runny nose
  • sneezing
  • sore throat
  • tingling of the hands or feet
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • yellow eyes or skin
Less common
  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • blindness
  • blood in the urine or stools
  • bloody eye
  • blurred vision
  • bruising
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cloudy urine
  • congestion
  • decreased vision
  • diarrhea
  • difficult, burning, or painful urination
  • dryness or soreness of the throat
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • hoarseness
  • joint pain
  • large, flat, or blue or purplish patches in the skin
  • longer or heavier menstrual periods
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • pinpoint red spots on the skin
  • redness of the eye
  • shivering
  • sweating
  • tender, swollen glands in the neck
  • trouble with sleeping
  • trouble with swallowing
  • voice changes
  • vomiting

Some side effects of eltrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased appetite
  • difficulty with moving
  • hair loss or thinning of the hair
  • itching skin
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pains or stiffness
  • swollen joints
Less common
  • Acid or sour stomach
  • back pain
  • belching
  • bone pain
  • dry mouth
  • heartburn
  • indigestion
  • rash
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to eltrombopag: oral tablet

Hematologic

In clinical studies, hemorrhage was the most common serious adverse reaction and most hemorrhagic reactions followed discontinuation of eltrombopag (the active ingredient contained in Promacta)

Hematologic side effects have included hemorrhage and thrombocytopenia (2%).

Gastrointestinal

Gastrointestinal side effects have included nausea (6%), vomiting (4%), and dyspepsia (2%).

Other

Other side effects have included menorrhagia (4%), paresthesia (3%), and ecchymosis (2%).

Musculoskeletal

Musculoskeletal side effects have included myalgia (3%).

Ocular

Ocular side effects have included cataracts (3%) and conjunctival hemorrhage (2%).

Hepatic

Hepatic side effects have included increased ALT (2%) and increased AST (2%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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