Picato Side Effects
Generic Name: ingenol topical
Note: This document contains side effect information about ingenol topical. Some of the dosage forms listed on this page may not apply to the brand name Picato.
Some side effects of Picato may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ingenol topical: topical application gel/jelly
Along with its needed effects, ingenol topical (the active ingredient contained in Picato) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ingenol topical:More common
- Blistering, peeling, or loosening of the skin
- pain and itching at the application site
- redness of the skin (severe)
- skin ulcers
- swelling of the skin
- Burning, dry, or itching eyes
- discharge or excessive tearing
- eye pain
- infection at the application site
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- swelling around the eyes
Some side effects of ingenol topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Flaking or scaling of the skin
- redness of the skin (mild)
For Healthcare Professionals
Applies to ingenol topical: topical gel
Local skin reactions were assessed within the selected treatment area and graded on a scale of 0 to 4. A grade of 0 represented no reaction present in the treated area and a grade of 4 indicated a marked and severe skin reaction that extended beyond the treated area. Local skin reactions generally occurred within 1 day of therapy initiation and peaked in intensity up to 1 week after therapy completion. Local skin reactions generally resolved within 2 weeks for areas treated on the face and scalp and within 4 weeks for areas treated on the trunk and extremities.
Local side effects have included application site pain (up to 15%), application site pruritus (8%), application site irritation (4%), application site infection (3%), and local skin reactions. Local skin reactions have included erythema (any Grade: up to 94%; Grade 4: up to 24%), flaking/scaling (any Grade: up to 90%; Grade 4: up to 9%), crusting (any Grade: up to 80%; Grade 4: up to 6%), swelling (any Grade: up to 79%; Grade 4: up to 5%), vesiculation/pustulation (any Grade: up to 56%; Grade 4: up to 5%), and erosion/ulceration (any Grade: up to 32%; Grade 4: up to 1%).
Ocular side effects have included periorbital edema (3%), eye pain, eyelid edema, eyelid ptosis, and conjunctivitis.
Nervous system side effects have included headache (2%).
Respiratory side effects have included nasopharyngitis (2%).
More about Picato (ingenol topical)
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