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Picato Gel

Generic Name: ingenol topical (IN je nol TOP i kal)
Brand Names: Picato

What is Picato gel?

Picato (ingenol) works by causing the death of certain cells in the body.

Picato gel is used to treat actinic keratosis (a condition caused by too much sun exposure).

Picato gel may also be used for purposes not listed in this medication guide.

Important information

Use Picato gel exactly as prescribed by your doctor. Using too much of this medicine, or using it for too long can increase your risk of severe skin reactions. Follow the directions on your prescription label.

Wash your hands with soap and water before and after applying the gel. Do not use Picato on sunburned skin, or on areas of skin that are still healing after surgery or treatment with other medications. Wait until these conditions have healed before using Picato. Do not get this medication in your eyes. If this does happen, rinse with water and call your doctor at once. Avoid getting the medication in your mouth or vagina. If it does get into any of these areas, rinse with water.

Avoid letting treated skin areas come into contact with other people. Avoid touching a treated skin area and then touching your eyes.

Call your doctor if your skin condition does not improve or if it gets worse during treatment.

Before taking this medicine

You should not use Picato gel if you are allergic to ingenol.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether ingenol topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Picato gel?

Use Picato gel exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Use only enough of this medicine to cover the affected areas.

Using too much of this medicine, or using it for too long can increase your risk of severe skin reactions.

Do not take by mouth. Picato gel is for use only on the skin. Do not apply this medicine near your lips, mouth, or vagina.

Do not apply Picato gel less than 2 hours before bedtime. Do not apply the medicine right after taking a shower.

Do not use on sunburned skin, or on areas of skin that are still healing after surgery or treatment with other medications. Wait until these conditions have healed before using Picato gel.

For 0.015% gel: To treat actinic keratosis on the face and scalp, the gel is usually applied once daily for 3 days in a row.

For 0.05% gel: To treat actinic keratosis on the arms and legs or trunk, Picato gel is usually applied once daily for 2 days in a row.

Wash your hands with soap and water after applying Picato gel.

Allow the skin to dry for at least 15 minutes after applying Picato gel. Do not cover the treated skin with a bandage.

Avoid touching or washing the treated skin for 6 hours after applying Picato gel. Avoid activities that may cause heavy sweating. After 6 hours have passed, you may wash the treated skin with a mild soap.

Call your doctor if your symptoms do not improve, or if they get worse.

Each single use tube of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after applying your dose.

Store this medicine in the refrigerator, do not freeze.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Picato dosing information

Usual Adult Dose for Keratosis:

Actinic keratosis:
Face and scalp:
0.015% gel: Apply to the affected area once a day for 3 consecutive days.

Trunk and extremities:
0.05% gel: Apply to the affected area once a day for 2 consecutive days.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe skin irritation.

What should I avoid while using Picato?

Avoid letting treated skin areas come into contact with other people. Avoid touching a treated skin area and then touching your eyes.

If this medicine gets in your eyes, rinse them thoroughly with water and seek medical attention right away.

Picato side effects

Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; difficulty breathing; swelling of your face, lips, tongue, or throat.

Wash off the medicine and call your doctor at once if you have a serious skin reaction to Picato gel such as severe itching, burning, oozing, blisters, redness, swelling, or skin changes where the medicine was applied.

Stop using Picato gel and call your doctor at once if you have:

  • severe eye pain or swelling;

  • puffy eyes; or

  • drooping eyelids.

Common Picato side effects may include:

  • mild skin irritation, itching, dryness, flaking, or crusting of the skin where the medicine was applied;

  • headache; or

  • sore throat, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Picato gel?

It is not likely that other drugs you take orally or inject will have an effect on topically applied ingenol. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Where can I get more information?

  • Your pharmacist can provide more information about Picato gel.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this Picato gel only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 2.01. Revision Date: 2015-08-28, 9:29:57 AM.

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