Phenoxybenzamine Side Effects

It is possible that some side effects of phenoxybenzamine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to phenoxybenzamine: oral capsule

In rats and mice, phenoxybenzamine has been found to increase the risk of development of malignant tumors. It is not known if phenoxybenzamine increases the chance of tumors in humans.

As well as its needed effects, phenoxybenzamine may cause unwanted side effects that require medical attention.

Some phenoxybenzamine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position
  • fast heartbeat
  • pinpoint pupils
  • stuffy nose
Less common
  • Confusion
  • drowsiness
  • dryness of mouth
  • headache
  • lack of energy
  • sexual problems in males
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to phenoxybenzamine: compounding powder, oral capsule

Cardiovascular

Cardiovascular side effects have included postural hypotension and tachycardia. These symptoms are evidence of adrenergic blockade and vary according to the degree of blockade.[Ref]

Genitourinary

Genitourinary side effects have included inhibition of ejaculation. This symptom is indicative of adrenergic blockade and varies according to the degree of blockade.[Ref]

Respiratory

Respiratory side effects have included nasal congestion. This symptom is indicative of adrenergic blockade and varies according to the degree of blockade.[Ref]

Ocular

Ocular side effects have included miosis. This symptom is indicative of adrenergic blockade and varies according to the degree of blockade.[Ref]

Nervous system

Nervous system side effects have included drowsiness and fatigue.[Ref]

Gastrointestinal

Gastrointestinal side effects have included gastrointestinal irritation.[Ref]

References

1. "Product Information. Dibenzyline Capsules (phenoxybenzamine)." SmithKline Beecham, Philadelphia, PA.

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