Phenelzine Side Effects

Brand Names: Nardil

Please note - some side effects for Phenelzine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Phenelzine - for the Consumer

Phenelzine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Phenelzine:

Changes in sexual function; constipation; dizziness; drowsiness; headache; sleeping problems; tiredness; tremors; twitching; unusual muscle movements; upset stomach; weakness; weight gain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; changes in heartbeat; chest pain; difficulty sleeping; feelings of irritability or hostility; impulsive behavior or other unusual changes in behavior; mental or mood changes; nausea; neck stiffness; panic attacks; severe anxiety or nervousness; severe headache; severe restlessness; suicidal thoughts or behaviors; urination problems; vomiting; worsening feelings of depression.

Side Effects by Body System

Nervous system

Nervous system side effects have included dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, tremors, twitching, myoclonic movements, and hyperreflexia. Less common side effects have included jitteriness, euphoria, nystagmus, paresthesias, ataxia, manic reaction, and convulsions.

Gastrointestinal

Gastrointestinal side effects have included constipation, dry mouth, and gastrointestinal disturbances.

Hepatic

Hepatic side effects have included elevated serum transaminases (without accompanying signs and symptoms). Less common side effects have included reversible jaundice and fatal progressive necrotizing hepatocellular damage.

Metabolic

Metabolic side effects have included weight gain and hypernatremia. Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated creatine kinase levels, metabolic acidosis, hypoxia, and coma) has been reported rarely and may resemble an overdose.

Cardiovascular

Cardiovascular side effects have included postural hypotension and edema.

Genitourinary

Genitourinary side effects have included sexual disturbances (e.g., anorgasmia, ejaculatory disturbances, and impotence) and urinary retention.

Dermatologic

Dermatologic side effects have included pruritus, skin rash, and sweating.

Ocular

Ocular side effects have included blurred vision and glaucoma.

Hematologic

Hematologic side effects have rarely included leukopenia.

Immunologic

Immunologic side effects have rarely included a lupus-like syndrome.

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