Phenelzine Side Effects
Some side effects of phenelzine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to phenelzine: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking phenelzine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Stop using phenelzine and call your doctor at once if you have any of these serious side effects:
sudden and severe headache, rapid heartbeat, stiffness in your neck, nausea, vomiting, cold sweat, sweating, vision problems, sensitivity to light;
chest pain, fast or slow heart rate;
swelling, rapid weight gain;
agitation, unusual thoughts or behavior; or
feeling light-headed, fainting.
Less serious side effects of phenelzine may include:
feeling weak or drowsy;
sleep problems (insomnia);
constipation, upset stomach;
dry mouth, decreased urination; or
impotence, difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
For Healthcare Professionals
Applies to phenelzine: oral tablet
Nervous system side effects have included dizziness, headache, drowsiness, sleep disturbances (including insomnia and hypersomnia), fatigue, tremors, twitching, myoclonic movements, and hyperreflexia. Less common side effects have included jitteriness, euphoria, nystagmus, paresthesias, ataxia, manic reaction, and convulsions.
Gastrointestinal side effects have included constipation, dry mouth, and gastrointestinal disturbances.
Hepatic side effects have included elevated serum transaminases (without accompanying signs and symptoms). Less common side effects have included reversible jaundice and fatal progressive necrotizing hepatocellular damage.
Metabolic side effects have included weight gain and hypernatremia. Hypermetabolic syndrome (which may include, but is not limited to, hyperpyrexia, tachycardia, tachypnea, muscular rigidity, elevated creatine kinase levels, metabolic acidosis, hypoxia, and coma) has been reported rarely and may resemble an overdose.
Cardiovascular side effects have included postural hypotension and edema.
Genitourinary side effects have included sexual disturbances (e.g., anorgasmia, ejaculatory disturbances, and impotence) and urinary retention.
Dermatologic side effects have included pruritus, skin rash, and sweating.
Ocular side effects have included blurred vision and glaucoma.
Hematologic side effects have rarely included leukopenia.
Immunologic side effects have rarely included a lupus-like syndrome.
More phenelzine resources
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