Pegvisomant Side Effects

It is possible that some side effects of pegvisomant may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pegvisomant: subcutaneous powder for solution

As well as its needed effects, pegvisomant may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pegvisomant, check with your doctor immediately:

More common
  • Bleeding, blistering, burning, coldness, or discoloration of skin at site of injection
  • bloating or swelling of face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • chills
  • cough
  • dizziness
  • feeling of pressure
  • fever
  • headache
  • hives
  • hoarseness
  • infection, inflammation, itching, or lump at site of injection
  • nervousness
  • lower back or side pain
  • painful or difficult urination
  • pounding in the ears
  • rapid weight gain
  • slow or fast heartbeat
  • tingling of hands or feet
  • unusual weight gain or loss
Less common
  • Thickening of the skin
Incidence not known
  • Abdominal pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • fever
  • itching
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • unusual tiredness or weakness
  • yellow eyes or skin

Some pegvisomant side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Accidental injury
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • general feeling of discomfort or illness
  • joint pain
  • muscle aches and pains
  • pain
  • pain or tenderness around eyes and cheekbones
  • runny or stuffy nose
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • sweating
  • tightness of chest or wheezing
  • trouble sleeping

For Healthcare Professionals

Applies to pegvisomant: subcutaneous powder for injection

Hepatic

During premarketing clinical studies two patients (0.8%) had elevations of serum concentrations of alanine aminotransferase and aspartate aminotransferase greater than 10 times the upper limit of normal. In both patients, the transaminase elevations normalized after discontinuation of the drug. In other studies, up to 12% of patients experienced abnormal liver function tests.

Hepatic side effects have included abnormal liver function tests (elevations of serum concentrations of alanine aminotransferase and aspartate aminotransferase) in up to 12% of patients treated.

Immunologic

Immunologic side effects have included the development of low titer non-neutralizing antigrowth hormone antibodies.

General

General side effects have included infection (23 to 33%), pain (8 to 23%), flu syndrome (12 to 21%), and accidental injury (8 to 18%).

Musculoskeletal

Musculoskeletal side effects have included back pain (8%) and chest pain (4%).

Respiratory

Respiratory side effects have included sinusitis (8%).

Gastrointestinal

Gastrointestinal side effects have included diarrhea (4%) and nausea (8%).

Nervous system

Nervous system side effects have included headache (26%), dizziness (8%) and paresthesias (7%).

Cardiovascular

Cardiovascular side effects have included hypertension (8%) and peripheral edema (8%).

Local

Local side effects have included injection site reactions (11%).

Metabolic

Metabolic side effects have included hypercholesterolemia (14%). Lipohypertrophy has been reported in less than 5% of patients following pegvisomant administration.

Hypersensitivity

Hypersensitivity reactions have included postmarketing reports of systemic hypersensitivity reactions including anaphylactic reactions, laryngospasm, angioedema, and generalized skin reactions (rash, erythema, pruritus, and urticaria).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)