Pegvisomant use while Breastfeeding
Drugs containing Pegvisomant: Somavert
Pegvisomant Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited data indicate that pegvisomant is poorly excreted into breastmilk. Because pegvisomant is not orally absorbed, it is unlikely to adversely affect the breastfed infant.
Drug Levels
A woman was being treated during pregnancy for acromegaly with subcutaneous pegvisomant at a dosage that was progressively escalated from 15 mg to 25 mg daily during the course of pregnancy, and presumably postpartum. At an unreported time postpartum, pegvisomant was not detectable (<50 mcg/L) in breastmilk. The patient's breastmilk growth hormone concentration was 0.6 mcg/L compared to <0.1 mcg/L in 3 breastmilk samples from normal healthy mothers.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
References
1. Brian SR, Bidlingmaier M, Wajnrajch MP et al. Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects. J Clin Endocrinol Metab. 2007; 92 :3374-7. PMID: 17595256
Pegvisomant Identification
Substance Name
CAS Registry Number
218620-50-9
Drug Class
- Human Growth Hormone Analogues and Derivatives
- Growth Hormone Receptor Antagonists
Administrative Information
LactMed Record Number
607
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2008-04-01
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Pegvisomant use during Pregnancy
- Pegvisomant Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
