Oxandrin Side Effects
Generic name: oxandrolone
Note: This document contains side effect information about oxandrolone. Some of the dosage forms listed on this page may not apply to the brand name Oxandrin.
Some side effects of Oxandrin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to oxandrolone: oral tablet
In rare cases, serious and even fatal cases of liver problems have developed during treatment with oxandrolone (the active ingredient contained in Oxandrin) Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.
If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical attention:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
swelling of the arms or legs (especially ankles);
frequent or persistent erections, or breast tenderness or enlargement (male patients); or
voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients).
Other less serious side effects may also occur. Talk to your doctor if you experience
new or worsening acne;
changes in sexual desire.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to oxandrolone: oral tablet
Cardiovascular side effects have included edema, with and without congestive heart failure.
Genitourinary side effects following chronic administration and/or large dosages of anabolic steroids have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop. Female patients may experience virilization including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of anabolic steroids at signs of mild virilization may prevent irreversible virilization. Alterations in libido may occur (increased/decreased).
Hepatic side effects have included life-threatening peliosis hepatitis and hepatic abnormalities, such as hepatic neoplasms and hepatocellular carcinomas, following prolonged therapy with high doses of anabolic steroids. Tumor regression did not occur in all cases following medication withdrawal. Cholestatic hepatitis, jaundice, and abnormal liver function tests can occur at relatively low dosages.
Hepatic tumors associated with anabolic steroid use are more vascular than other hepatic tumors and may remain silent until the development of life-threatening abdominal hemorrhage. Peliosis hepatitis may present as mild liver dysfunction, but has resulted in liver failure.
Other side effects have included virilization of female patients including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of anabolic steroids at signs of mild virilization may prevent irreversible virilization
Musculoskeletal effects have included termination of linear bone growth due to closure of the epiphyseal growth centers. Appropriate monitoring of bone age is recommended during use in prepubertal patients.
Hematologic side effects have included alterations in clotting factors II, V, VII and X, prolonged prothrombin time (PT), and increased red cell production.
Endocrine side effects have included inhibition of endogenous testosterone release by means of feedback inhibition of pituitary luteinizing hormone (LH). Large doses of exogenous anabolic steroids may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone (FSH). The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction.
Metabolic side effects have included osteolytic-induced hypercalcemia in immobilized patients or those with metastatic breast disease. Anabolic steroids affect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred during anabolic steroid therapy. Decreased glucose tolerance requiring adjustments in hyperglycemic control has been noted in diabetic patients. The androgenic activity of anabolic steroids may decrease levels of thyroxin-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred.
Renal side effects have included retention of nitrogen, sodium, potassium, chloride, water and phosphorus, and decreased urinary excretion of calcium.
Oncologic side effects have included hepatic neoplasms and hepatocellular carcinomas following prolonged therapy with large doses of anabolic steroids.
Gastrointestinal side effects have included nausea, vomiting, and diarrhea.
Psychiatric side effects have included habituation, excitation, insomnia, depression, and libido changes.
Dermatologic side effects have included acne and changes in skin color. The greatest incidence of occurrence has been in women and prepubertal males.
More Oxandrin resources
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.