Moxilin Side Effects

Generic Name: amoxicillin

Note: This page contains information about the side effects of amoxicillin. Some of the dosage forms included on this document may not apply to the brand name Moxilin.

Not all side effects for Moxilin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amoxicillin: oral capsule, oral powder for suspension, oral tablet, oral tablet for suspension, oral tablet chewable, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by amoxicillin (the active ingredient contained in Moxilin). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amoxicillin:

Incidence not known
  • Abdominal or stomach cramps or tenderness
  • back, leg, or stomach pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine
  • bloody nose
  • chest pain
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • diarrhea
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with breathing
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • fever
  • general body swelling
  • headache
  • heavier menstrual periods
  • hives or welts
  • increased thirst
  • inflammation of the joints
  • itching
  • joint or muscle pain
  • loss of appetite
  • muscle aches
  • nausea or vomiting
  • nosebleeds
  • pain
  • pain in the lower back
  • pain or burning while urinating
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red, irritated eyes
  • redness, soreness, or itching skin
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sores, welting, or blisters
  • sudden decrease in the amount of urine
  • swollen, lymph glands
  • tenderness
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting of blood
  • watery or bloody diarrhea
  • wheezing
  • yellow eyes or skin

Some of the side effects that can occur with amoxicillin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
Incidence not known
  • Agitation
  • black, hairy tongue
  • changes in behavior
  • confusion
  • convulsions
  • discoloration of the tooth (brown, yellow, or gray staining)
  • dizziness
  • sleeplessness
  • trouble with sleeping
  • unable to sleep
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

For Healthcare Professionals

Applies to amoxicillin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet dispersible, oral tablet extended release

Hypersensitivity

Hypersensitivity reactions are more likely in patients with a history of allergy, asthma, hay fever, or urticaria.[Ref]

Hypersensitivity reactions have been reported in up to 10% of patients and have included anaphylaxis, urticarial rash, erythematous maculopapular rash, serum sickness-like reactions, erythema multiforme, urticaria, edema, hypotension, fever, eosinophilia, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis, angioedema, Stevens-Johnson syndrome, and dyspnea.[Ref]

Dermatologic

Dermatologic side effects have included rash, fixed drug eruption, and bullous pemphigoid. Erythematous maculopapular rashes occur frequently in patients with infectious mononucleosis who take amoxicillin (the active ingredient contained in Moxilin) these may be due to hypersensitivity.[Ref]

Three out of four patients with infectious mononucleosis and an amoxicillin-associated rash displayed hypersensitivity to amoxicillin and ampicillin by skin tests and lymphocyte transformation tests. Two of these patients had side-chain-specific sensitization.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, vomiting, generalized abdominal cramps, colitis, hemorrhagic colitis, pseudomembranous colitis (Clostridium difficile associated diarrhea), and black hairy tongue. Abdominal pain has also been reported.[Ref]

Amoxicillin has been associated with hemorrhagic, sometimes inflammatory colitis, which typically affects the ascending colon. Clostridium difficile pseudomembranous colitis has been reported.[Ref]

Renal

Renal side effects have included crystalluria and acute interstitial nephritis, often associated with fever, rash and eosinophilia.[Ref]

Hematologic

A patient undergoing dental extraction and receiving warfarin anticoagulation therapy had prolonged bleeding times (PT and INR), and decreased hemoglobin and hematocrit. The bleeding was felt due to vitamin K deficiency as a result of depletion of intrinsic vitamin K-producing gut flora from use of amoxicillin (the active ingredient contained in Moxilin) for prophylaxis of subacute bacterial endocarditis.[Ref]

Hematologic side effects associated with penicillins have included thrombocytopenia, anemia, leukopenia, thrombocytopenic purpura, agranulocytosis, hemolytic anemia, eosinophilia, and granulocytopenia. These effects are usually reversible and are believed to be due to hypersensitivity reactions.[Ref]

Immunologic

Immunologic side effects have included mucocutaneous candidiasis and vulvovaginal mycotic infection.

Nervous system

Nervous system side effects have rarely included headache, somnolence, dizziness, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and aseptic meningitis. Rare cases of psychosis associated with amoxicillin (the active ingredient contained in Moxilin) therapy have been reported but may have been due to underlying infection or concomitant medication.[Ref]

Hepatic

Hepatic side effects have included moderate elevations of AST (SGOT) and/or ALT (SGPT) levels, cholestatic jaundice, hepatic cholestasis, and acute cytolytic hepatitis.[Ref]

Other

Other side effects have rarely included brown, yellow, or gray tooth discoloration, primarily in pediatric patients. Brushing or dental cleaning reduced or eliminated the discoloration in most cases.[Ref]

Respiratory

Respiratory side effects have included cough and rhinorrhea.[Ref]

References

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7. Appel GB, Garvey G, Silva F, Francke E, Neu HC, Weisman J "Acute interstitial nephritis due to amoxicillin therapy." Nephron 27 (1981): 313-5

8. Lee P, Shanson D "Results of a UK survey of fatal anaphylaxis after oral amoxicillin." J Antimicrob Chemother 60 (2007): 1172-3

9. Macfarlane JT, Prewitt J, Gard P, Guion A "Comparison of amoxycillin and clarithromycin as initial treatment of community-acquired lower respiratory tract infections." Br J Gen Pract 46 (1996): 357-60

10. Shuttleworth D "A localized, recurrent pustular eruption following amoxycillin administration." Clin Exp Dermatol 14 (1989): 367-8

11. Vega JM, Blanca M, Garcia JJ, Carmona MJ, Miranda A, Perezestrada M, Fernandez S, Acebes JM, Terrados S "Immediate allergic reactions to amoxicillin." Allergy 49 (1994): 317-22

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13. Dickinson RJ, Meyer P, Warren RE "Hemorrhagic colitis." Dig Dis Sci 27 (1982): 187

14. Singer DR, Simpson JG, Catto GR, Johnston AW "Drug hypersensitivity causing granulomatous interstitial nephritis." Am J Kidney Dis 11 (1988): 357-9

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16. Roujeau JC, Kelly JP, Naldi L, et al. "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis." N Engl J Med 333 (1995): 1600-7

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18. Sidoroff A, Dunant A, Viboud C, et al. "Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR)." Br J Dermatol 157 (2007): 989-96

19. Vandenplas O, Delwiche JP, DeJonghe M "Asthma to latex and amoxicillin." Allergy 52 (1997): 1147-9

20. Castro SM, Schwartz RH, Nazarian LF "Ampicillin and amoxicillin delayed hypersensitivity: Side-chain-specific allergic reactions in a child." Pediatr Asthma Allerg Immun 10 (1996): 197-203

21. Salvo F, Polimeni G, Moretti U, et al. "Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy." J Antimicrob Chemother 60 (2007): 121-6

22. Adcock BB, Rodman DP "Ampicillin-specific rashes." Arch Fam Med 5 (1996): 301-4

23. Renn CN, Straff W, Dorfmuller A, Al-Masaoudi T, Merk HF, Sachs B "Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity." Br J Dermatol 147 (2002): 1166-70

24. Chowdhury FH "Fixed genital drug eruption." Practitioner 226 (1982): 1450

25. Katz M, Seidenbaum M, Weinrauch L "Penicillin-induced generalized pustular psoriasis." J Am Acad Dermatol 17 (1987): 918-20

26. Arias J, Fernandezrivas M, Panadero P "Selective fixed drug eruption to amoxycillin." Clin Exp Dermatol 20 (1995): 339-40

27. Prieto A, deBarrio M, LopezSaez P, Baeza ML, deBenito V, Olalde S "Recurrent localized pustular eruption induced by amoxicillin." Allergy 52 (1997): 777-8

28. Alcaley J, David M, Ingber A, Hazaz B, Sandbank M "Bullous pemphigold mimicking bullous erythema multiforme: an untoward side effect of penicillins." J Am Acad Dermatol 18 (1988): 345-9

29. Miralles J, Barnadas MA, Baselga E, Gelpi C, Rodriguez JL, deMoragas JM "Bullous pemphigoid-like lesions induced by amoxicillin." Int J Dermatol 36 (1997): 42-7

30. Iravani A, Richard GA, Johnson D, Bryant A "A double-blind, multicenter, comparative study of the safety and efficacy of cefixime versus amoxicillin in the treatment of acute urinary tract infections in adult." Am J Med 85 (1988): 17-23

31. Delpre G, Livni E, Niv Y "Urticaria during triple therapy for Helicobacter pylori infection : Clinical implications." Dig Dis Sci 42 (1997): 728-30

32. Philbrick AM, Ernst ME "Amoxicillin-Associated Hemorrhagic Colitis in the Presence of Klebsiella oxytoca." Pharmacotherapy 27 (2007): 1603-7

33. Keshavarzian A, Saverymuttu SH, Chadwick VS "Indium leucocyte scanning in ampicillin-associated right-sided hemorrhagic colitis." Am J Gastroenterol 79 (1984): 541-2

34. Rydning A, Anderssen R, Narverud G, Hoiby EA "Antibiotic-associated pseudomembranous colitis." J Oslo City Hosp 32 (1982): 141-5

35. Handsfield HH, Clark H, Wallace JF, Holmes KK, Turck M "Amoxicillin, a new penicillin antibiotic." Antimicrob Agents Chemother 3 (1973): 262-5

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39. Bandrowsky T, Vorono AA, Borris TJ, Marcantoni HW "Amoxicillin-related postextraction bleeding in an anticoagulated patient with tranexamic acid rinses." Oral Surg Oral Med Oral Pathol 82 (1996): 610-2

40. Wittmann A, Wooten GF "Amoxicillin-induced aseptic meningitis." Neurology 57 (2001): 1734

41. Bell CL, Watson B, Waring WS "Acute psychosis caused by co-amoxiclav." BMJ 337 (2008): a2117

42. Whyte CA, Shivdat-Nanhoe R, Kramer P "A Case of Amoxicillin-Induced Meningitis." Clin Infect Dis 46 (2008): 642

43. Hong L, Levy SM, Warren JJ, Dawson DV, Bergus GR, Wefel JS "Association of amoxicillin use during early childhood with developmental tooth enamel defects." Arch Pediatr Adolesc Med 159 (2005): 943-8

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