Milnacipran Side Effects

Brand Names: Savella

Please note - some side effects for Milnacipran may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Milnacipran - for the Consumer

Milnacipran

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Milnacipran:

Constipation; decreased sexual desire or ability; dizziness; dry mouth; headache; hot flush; increased sweating; loss of appetite; nausea; trouble sleeping; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; bloody or black, tarry stools; confusion; dark urine; decreased concentration; decreased coordination; excessive sweating; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; memory problems; muscle pain or weakness; new or worsening agitation, anxiety, depression, panic attacks, aggressiveness, impulsiveness, irritability, hostility, restlessness, or inability to sit still; pale stools; red, swollen, blistered, or peeling skin; seizures; severe or persistent headache or dizziness; severe or persistent nausea, vomiting, or diarrhea; severe or persistent trouble sleeping; stomach pain; suicidal thoughts or attempts; tremor; trouble urinating; unusual bruising or bleeding; unusual or severe mental or mood changes; unusual weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Gastrointestinal

Gastrointestinal side effects including nausea (37%), constipation (16%), vomiting (7%), dry mouth (5%), abdominal pain (3%), decreased appetite (2%), diarrhea, dyspepsia, gastroesophageal reflux disease, flatulence, and abdominal distension have been reported.

Nervous system

Nervous system side effects including headache (18%), dizziness (10%), migraine (5%), paresthesia (2%), tremor (2%), hypoesthesia (1%), tension headache (1%), somnolence, dysgeusia, convulsions (including grand mal), loss of consciousness, neuroleptic malignant syndrome, Parkinsonism, and serotonin syndrome have been reported.

Psychiatric

Psychiatric side effects including insomnia (12%), anxiety (4%), depression, stress, anorexia, delirium, and hallucination have been reported.

Cardiovascular

Cardiovascular side effects including hot flush (12%), palpitations (7%), increased heart rate (6%), hypertension (5%), flushing (3%), increased blood pressure (3%), tachycardia (2%), supraventricular tachycardia, and hypertensive crisis have been reported. A case of Raynaud's syndrome has also been reported.

Dermatologic

Dermatologic side effects including hyperhidrosis (9%), rash (3%), pruritus (2%), night sweats, erythema multiforme, and Stevens Johnson syndrome have been reported.

Respiratory

Respiratory side effects including upper respiratory tract infection (6%) and dyspnea (2%) have been reported.

General

General side effects including chest pain (2%), chills (2%), chest discomfort (1%), fatigue, peripheral edema, irritability, pyrexia, decreased weight, and increased weight have been reported.

Ocular

Ocular side effects including blurred vision (2%) and accommodation disorder have been reported.

Genitourinary

Genitourinary side effects including dysuria, ejaculation disorder, erectile dysfunction, ejaculation failure, decreased libido, prostatitis, scrotal pain, testicular pain, testicular swelling, urinary hesitation, urinary retention, urethral pain, decreased urine flow, cystitis, and galactorrhea have been reported.

Other

Other side effects including contusion, fall, and physical dependence have been reported.

Milnacipran produces physical dependence, including withdrawal symptoms following drug discontinuation, similar to other SNRIs and SSRIs. These withdrawal symptoms can be severe.

Metabolic

Metabolic side effects including hypercholesterolemia and hyponatremia have been reported.

Renal

Renal side effects including urinary tract infection and acute renal failure have been reported.

Hematologic

Hematologic side effects including leukopenia, neutropenia, and thrombocytopenia have been reported.

Endocrine

Endocrine side effects including hyperprolactinemia have been reported.

Hepatic

Hepatic side effects including hepatitis have been reported.

Musculoskeletal

Musculoskeletal side effects including rhabdomyolysis have been reported.

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