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Midodrine Side Effects

Medically reviewed by Drugs.com. Last updated on Oct 26, 2023.

Applies to midodrine: oral tablet.

Warning

Oral route (Tablet)

Can cause marked elevation of supine blood pressure and should be used only in patients whose lives are considerably impaired despite standard clinical care. Clinical benefits of midodrine hydrochloride tablets, principally improved ability to carry out activities of daily living, have not been verified.

Serious side effects of Midodrine

Along with its needed effects, midodrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking midodrine:

More common

Rare

Other side effects of Midodrine

Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

For Healthcare Professionals

Applies to midodrine: oral tablet.

General

The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]

Cardiovascular

Common (1% to 10%): Supine hypertension, flushing

Uncommon (0.1% to 1%): Reflex bradycardia

Rare (less than 0.1%): Tachycardia, palpitations

Frequency not reported: Vasodilation/flushing face[Ref]

Nervous system

Very common (10% or more): Paresthesia (18.3%)

Common (1% to 10%): Headache

Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]

Dermatologic

Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)

Common (1% to 10%): Rash

Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]

Genitourinary

Very common (10% or more): Dysuria (13.4%)

Frequency not reported: Impaired urination[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, stomatitis

Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]

Other

Common (1% to 10%): Chills, pain

Frequency not reported: Asthenia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability

Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]

Hepatic

Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]

Musculoskeletal

Frequency not reported: Backache, leg cramps[Ref]

Ocular

Frequency not reported: Visual field defect[Ref]

References

1. Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer