Drug Information
Side Effects > Midodrine

Midodrine Side Effects

Brand Names: ProAmatine

Please note - some side effects for Midodrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).


For the consumer

For the professional

Side Effects of Midodrine - for the consumer


Midodrine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Midodrine:

Abnormal skin sensations or itching, especially of the scalp; chills; goosebumps; increased or frequent urination.

Seek medical attention right away if any of these SEVERE side effects occur when using Midodrine:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion or abnormal thinking; decreased urination; fainting; headache; increased or unusual dizziness; pounding in the ears or the chest; slow pulse; vision changes.

Top

For the professional


Midodrine

The most frequent adverse reactions seen in controlled trials were supine and sitting hypertension; paresthesia and pruritus, mainly of the scalp; goosebumps; chills; urinary urge; urinary retention and urinary frequency.

The frequency of these events in a 3-week placebo-controlled trial is shown in the following table:

Adverse Events

1Includes hyperesthesia and scalp paresthesia

2Includes dysuria (1), increased urinary frequency (2), impaired urination (1), urinary retention (5), urinary urgency (2)

3Includes scalp pruritus

4Includes patients who experienced an increase in supine hypertension

5Includes abdominal pain and pain increase

Placebo
n=88
Midodrine
n=82
Event # of reports % of patients # of reports % of patients
Total # of reports 22 77
Paresthesia1 4 4.5 15 18.3
Piloerection 0 0 11 13.4
Dysuria2 0 0 11 13.4
Pruritis3 2 2.3 10 12.2
Supine
hypertension4
0 0 6 7.3
Chills 0 0 4 4.9
Pain5 0 0 4 4.9
Rash 1 1.1 2 2.4

Less frequent adverse reactions were headache; feeling of pressure/fullness in the head; vasodilation/flushing face; confusion/thinking abnormality; dry mouth; nervousness/anxiety and rash. Other adverse reactions that occurred rarely were visual field defect; dizziness; skin hyperesthesia; insomnia; somnolence; erythema multiforme; canker sore; dry skin; dysuria; impaired urination; asthenia; backache; pyrosis; nausea; gastrointestinal distress; flatulence and leg cramps.

The most potentially serious adverse reaction associated with Midodrine therapy is supine hypertension. The feelings of paresthesia, pruritus, piloerection and chills are pilomotor reactions associated with the action of Midodrine on the alpha-adrenergic receptors of the hair follicles. Feelings of urinary urgency, retention and frequency are associated with the action of Midodrine on the alpha-receptors of the bladder neck.

Top

More resources:

Cerner Multum midodrine

MedFacts Midodrine

Micromedex Midodrine - Includes detailed dosage instructions.

FDA ProAmatine

FDA Midodrine

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.


MedNotes
Advertisement