Midodrine Side Effects
Some side effects of midodrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to midodrine: oral tablet
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
If you experience any of the following serious side effects, stop taking midodrine and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); or
irregular heartbeats, fluttering feeling in the chest, or chest pain.
Other, less serious side effects may be more likely to occur. Continue to take midodrine and talk to your doctor if you experience
chills or goosebumps;
itching or tingling of the skin;
increased need to urinate or difficulty with urination;
feeling of pressure or fullness in the head;
dryness of the mouth; or
nervousness or anxiety.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to midodrine: oral tablet
Marked elevation of supine arterial blood pressure is potentially the most serious side effect reported with midodrine therapy. The manufacturer reports a systolic pressure of 200 mmHg in 13.4% of patients receiving midodrine 10 mg orally. Patients with a mean pretreatment systolic pressure of 170 mmHg were more prone to this effect. There is no experience of midodrine administered to patients with a pretreatment systolic pressure over 180 mmHg.
The patient may be able to control supine hypertension by avoiding a full supine position.
Symptoms of supine hypertension may included, but are not limited to, cardiac awareness, pounding in the ears, headache, and blurred vision.
Cardiovascular side effects have frequently included supine and sitting hypertension.
Nervous system side effects have frequently included paresthesia (18.3%). Confusion, abnormal thinking, nervousness, and anxiety have also been reported. Dizziness, skin hyperesthesia, insomnia, and somnolence have been reported rarely.
Scalp pruritus is the most common form of pruritus reported by patients.
Dermatologic side effects have frequently included piloerection (13.4%) and pruritus (12.2%). Rash has been reported in 2.4% of patients. Erythema multiforme and dry skin have been reported rarely.
Other side effects have frequently included chills (4.9%) and pain/increase in level of pain (4.9%). Headache, feeling of pressure/fullness in the head, vasodilation/flushing of face, and dry mouth have also been reported. Leg cramps, canker sore, and backache have been reported rarely.
Reports of dysuria have included urinary urge, urinary retention, urinary frequency, and impaired urination.
Genitourinary side effects have frequently included dysuria (13.4%).
Ocular side effects have rarely included visual field defect.
Gastrointestinal side effects have rarely included pyrosis, nausea, gastrointestinal distress, and flatulence.
Musculoskeletal side effects have rarely included asthenia.
More midodrine resources
- midodrine Concise Consumer Information (Cerner Multum)
- midodrine MedFacts Consumer Leaflet (Wolters Kluwer)
- midodrine Advanced Consumer (Micromedex) - Includes Dosage Information
- Midodrine Prescribing Information (FDA)
- Midodrine Hydrochloride Monograph (AHFS DI)
- ProAmatine Prescribing Information (FDA)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.