Midodrine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypotension

Symptomatic orthostatic hypotension:

10 mg orally three times a day. Do not give more frequently than every 3 hours, after the evening meal, or less than 4 hours before bedtime.

Single doses of up to 20 mg orally have been administered to healthy adult patients. However, supine/sitting hypertension has been reported in up to 45% of patients with this dose, compared to 7.3% of patients receiving a dose of 10 mg orally.

Single doses of greater than 30 mg have been administered to healthy adult patients. However, the safety and efficacy of this dose has not been established.

Renal Dose Adjustments

CrCl less than 80 mL/min: initiate treatment using 2.5 mg doses. Dose adjustments should be made cautiously.

Liver Dose Adjustments

Use with caution in patients with liver dysfunction.

Precautions

The potential for supine and sitting hypertension should be evaluated before starting therapy.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Desglymidodrine is dialyzable.

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