Lucentis Side Effects
Generic Name: ranibizumab ophthalmic
Note: This document contains side effect information about ranibizumab ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Lucentis.
Some side effects of Lucentis may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ranibizumab ophthalmic: intraocular solution
Along with its needed effects, ranibizumab ophthalmic (the active ingredient contained in Lucentis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ranibizumab ophthalmic:More common
- bloody eye
- blurred vision or loss of vision
- decreased vision or other changes in vision
- disturbed color perception
- double vision
- dry eye
- eye pain
- feeling of having something in the eye
- halos around lights
- night blindness
- overbright appearance of lights
- pain or tenderness around the eyes and cheekbones
- red, sore eyes
- redness of the white part of the eyes or inside of the eyelids
- redness, swelling, or itching of the eyelid
- seeing flashes or sparks of light
- seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
- sensitivity of the eye to light
- tearing of the eyes
- tunnel vision
- watering of the eyes
- Body aches or pain
- chest pain
- difficulty with breathing
- dry mouth
- fast, slow, or irregular heartbeat
- general feeling of discomfort or illness
- head congestion
- hoarseness, loss of voice, or other voice changes
- loss of consciousness
- muscle aches and pains
- nasal congestion
- pain in the chest, groin, or legs, especially the calves
- painful blisters on the trunk of the body
- pale skin
- runny nose
- severe, sudden headache
- shortness of breath
- slurred speech
- sore throat
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sudden, unexplained shortness of breath
- tightness in the chest
- trouble sleeping
- troubled breathing
- unexplained weight loss
- unusual tiredness or weakness
Some side effects of ranibizumab ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- difficulty having a bowel movement (stool)
- difficulty with moving
- muscle stiffness
- swelling or redness in the joints
For Healthcare Professionals
Applies to ranibizumab ophthalmic: intraocular solution
Cardiovascular side effects including peripheral edema (up to 6%) and atrial fibrillation (up to 5%).
Although a low rate of arterial thromboembolic events were observed in clinical trials, there is a potential risk of ATE's (nonfatal stroke, nonfatal myocardial infarction, or vascular death) following intravitreal use of VEGF inhibitors.
Gastrointestinal side effects including nausea (up to 10%), constipation (up to 8%), and gastroesophageal reflux disease (up to 6%) have been reported.
General side effects including wound healing complications (up to 1%) have been reported.
Hematologic side effects including anemia (up to 11%) have been reported.
The pretreatment incidence of immunoreactivity to ranibizumab was 0% to 5% across treatment groups. After monthly dosing with ranibizumab for 6 to 24 months, antibodies to ranibizumab were detected in approximately 1% to 8% of patients. The immunogenicity data reflect the percentage of patients whose test results were considered positive for antibodies to ranibizumab in immunoassays and are highly dependent on the sensitivity and specificity of the assay. The clinical significance of immunoreactivity to ranibizumab is unclear at this time, although some patients with the highest levels of immunoreactivity were noted to have iritis or vitritis.
Immunologic side effects including seasonal allergies (up to 8%) and immunogenicity have been reported.
Metabolic side effects include hypercholesterolemia (up to 7%).
Musculoskeletal side effects including arthralgia (up to 11%) have been reported.
Nervous system side effects including headache (up to 12%) and peripheral neuropathy (up to 5%) have been reported.
Conjunctival hemorrhage (up to 74%), eye pain (up to 35%), vitreous floaters (up to 27%), increased intraocular pressure (up to 24%), vitreous detachment (up to 21%), intraocular inflammation (up to 18%), cataract (up to 28%), foreign body sensation in the eye (up to 16%), eye irritation (up to 15%), increased lacrimation (up to 14%), blepharitis (up to 12%), dry eye (up to 12%), visual disturbance or blurred vision (up to 18%), eye pruritus (up to 12%), ocular hyperemia (up to 11%), retinal disorder (up to 10%), maculopathy (up to 11%), retinal degeneration (up to 8%), ocular discomfort (up to 7%), conjunctival hyperemia (up to 7%), posterior capsule opacification (up to 7%), and injection site hemorrhage (up to 5%) have also been reported.
Ocular side effects including endophthalmitis, rhegmatogenous retinal detachments, and iatrogenic traumatic cataracts are serious adverse events related to the injection procedure that have occurred in less than 0.1% of intravitreal injections.
Tear of the retinal pigment epithelium among neovascular AMD patients has been identified postmarketing.
Renal side effects including renal failure (up to 7%) and chronic renal failure (up to 6%) have been reported.
Respiratory side effects including nasopharyngitis (up to 16%), bronchitis (up to 11%), cough (up to 9%), upper respiratory tract infection (up to 9%), sinusitis (up to 8%), influenza (up to 7%), and chronic obstructive pulmonary disease (up to 6%) have been reported.
More about Lucentis (ranibizumab ophthalmic)
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