Lopid Side Effects

Generic name: gemfibrozil

Medically reviewed by Drugs.com. Last updated on Jul 17, 2023.

Note: This document contains side effect information about gemfibrozil. Some dosage forms listed on this page may not apply to the brand name Lopid.

Applies to gemfibrozil: oral tablet.

Serious side effects of Lopid

Along with its needed effects, gemfibrozil (the active ingredient contained in Lopid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking gemfibrozil:

More common

• Bladder pain
• bloody or cloudy urine
• cough or hoarseness
• difficult, burning, or painful urination
• fever or chills
• frequent urge to urinate
• lower back or side pain

Incidence not known

• Black, tarry stools
• chest pain
• dark-colored urine
• indigestion
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• muscle cramps or spasms
• muscle pain or stiffness
• muscular pain, tenderness, wasting, or weakness
• pale skin
• severe nausea or vomiting
• shortness of breath
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• swollen glands
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness

Other side effects of Lopid

Some side effects of gemfibrozil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach
• bad, unusual, or unpleasant (after) taste
• belching
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• change in taste
• diarrhea
• heartburn
• stomach discomfort or upset

Less common

• Difficulty having a bowel movement (stool)
• dizziness or lightheadedness
• feeling of constant movement of self or surroundings
• headache
• nausea
• sensation of spinning
• skin rash, encrusted, scaly and oozing
• vomiting

For Healthcare Professionals

Applies to gemfibrozil: compounding powder, oral tablet.

General

The most frequently reported side effects were gastrointestinal reactions and included dyspepsia, abdominal pain, diarrhea, nausea, vomiting, acute appendicitis, constipation, and flatulence.^[Ref]

Gastrointestinal

Very common (10% or more): Dyspepsia (19.6%)

Common (1% to 10%): Abdominal pain, acute appendicitis, diarrhea, nausea, vomiting, constipation, flatulence

Rare (less than 0.1%): Pancreatitis

Frequency not reported: Colitis^[Ref]

Nervous system

Common (1% to 10%): Headache

Rare (less than 0.1%): Peripheral neuropathy, paresthesia, dizziness, somnolence

Frequency not reported: Peripheral neuritis, convulsions, syncope, hyperesthesia, taste perversion, intracerebral hemorrhage^[Ref]

Hepatic

Rare (less than 0.1%): Hepatitis, cholestatic jaundice, cholelithiasis, cholecystitis, hepatic function abnormal

Frequency not reported: ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased^[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Atrial fibrillation

Frequency not reported: Extrasystoles, vasculitis, peripheral vascular disease^[Ref]

Dermatologic

Common (1% to 10%): Eczema, rash

Rare (less than 0.1%): Angioedema, urticaria, exfoliative dermatitis, dermatitis, pruritus, alopecia, photosensitivity reaction^[Ref]

Other

Common (1% to 10%): Fatigue, vertigo

Rare (less than 0.1%): Creatine phosphokinase increased

Frequency not reported: Weight loss, viral infections, bacterial infections^[Ref]

Musculoskeletal

Rare (less than 0.1%): Myopathy, myalgia, painful extremities, arthralgia, synovitis, rhabdomyolysis, myositis, muscular weakness

Frequency not reported: Lupus-like syndrome, myasthenia^[Ref]

Hematologic

Rare (less than 0.1%): Bone marrow failure, severe anemia, thrombocytopenia, leukopenia, eosinophilia, hemoglobin decreased, hematocrit decreased, WBC decreased

Frequency not reported: Anemia, bone marrow hypoplasia^[Ref]

Ocular

Rare (less than 0.1%): Blurred vision

Frequency not reported: Retinal edema, cataracts^[Ref]

Genitourinary

Rare (less than 0.1%): Erectile dysfunction

Frequency not reported: Impotence, male fertility decreased^[Ref]

Psychiatric

Rare (less than 0.1%): Libido decreased, depression

Frequency not reported: Confusion^[Ref]

Respiratory

Rare (less than 0.1%): Laryngeal edema^[Ref]

Renal

Frequency not reported: Renal dysfunction, renal failure^[Ref]

Oncologic

Frequency not reported: Hepatoma^[Ref]

Immunologic

Frequency not reported: Positive antinuclear antibody, anaphylaxis^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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