Lexiscan Side Effects

Generic Name: regadenoson

Note: This page contains side effects data for the generic drug regadenoson. It is possible that some of the dosage forms included below may not apply to the brand name Lexiscan.

It is possible that some side effects of Lexiscan may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to regadenoson: intravenous solution

Along with its needed effects, regadenoson (the active ingredient contained in Lexiscan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking regadenoson:

More common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • difficult or labored breathing
  • fast or irregular heartbeat
  • nausea
  • sweating
  • tightness in the chest
Incidence not known
  • Confusion
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash, hives, or itching skin
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking regadenoson:

Symptoms of overdose
  • Dizziness
  • feeling of warmth
  • increased heart rate
  • redness of the face, neck, arms, and occasionally, upper chest

Some side effects of regadenoson may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
Less common
  • Change in taste
  • loss of taste
  • stomach soreness or discomfort
Incidence not known
  • Diarrhea
  • difficulty with moving
  • joint pain
  • muscle aching or cramping

For Healthcare Professionals

Applies to regadenoson: intravenous solution


Respiratory side effects including dyspnea (28%) have been reported.

Nervous system

Nervous system side effects including headache (26%) and dizziness (8%) have been reported.


Cardiovascular side effects have included tachycardia (22%), flushing (16%), premature ventricular contractions (14%), chest discomfort (13%), angina or ST segment depression (12%), Chest pain (7%), premature atrial contractions (7%), systolic blood pressure decreased greater than 35 mm Hg (7%), ventricular conduction abnormalities (6%) diastolic blood pressure decreased more than 25 mm Hg (4%), first-degree AV block (PR prolongation greater than 220 msec; 3%), second-degree AV block (less than 1%), AV conduction abnormalities (other than AV blocks; less than 1%).


Gastrointestinal side effects including nausea (6%), abdominal discomfort (5%), and dysgeusia (5%) have been reported.


General side effects including feeling hot (5%) have been reported.

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