Leucovorin Side Effects
Some side effects of leucovorin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to leucovorin: injectable, powder for solution, solution, tablet
Along with its needed effects, leucovorin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking leucovorin:Rare
- Skin rash, hives, or itching
Check with your doctor as soon as possible if any of the following side effects occur while taking leucovorin:Rare - reported with use in treatment of cancer
- Convulsions (seizures)
For Healthcare Professionals
Applies to leucovorin: compounding powder, injectable powder for injection, injectable solution, oral tablet
Hypersensitivity side effects, including hives, pruritus, urticaria, anaphylactoid reaction, and anaphylaxis have rarely been associated with both oral and parenteral administration of leucovorin.
Gastrointestinal side effects associated with orally administered leucovorin include transient diarrhea. Diarrhea is usually observed when leucovorin is given with 5-fluorouracil. It typically resolves spontaneously.
Limited data suggest the importance of folic acid antagonism as the basis for methotrexate activity in rheumatoid arthritis. More data are needed.
Musculoskeletal side effects have included increased musculoskeletal complaints and arthralgias, which have been associated with the use of low-dose orally administered leucovorin used to ameliorate side effects from methotrexate in patients with rheumatoid arthritis.
Hematologic side effects have included rare cases of thrombocytosis.
Respiratory side effects have included rare complaints of wheezing.
More about leucovorin
- Leucovorin powder
- Leucovorin solution
- Leucovorin Oral, Intravenous, Injection (Advanced Reading)
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