Leucovorin Side Effects

Please note - some side effects for Leucovorin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Leucovorin - for the Consumer

Leucovorin

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with Leucovorin. Seek medical attention right away if any of these SEVERE side effects occur when using Leucovorin:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Leucovorin Powder

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with Leucovorin Powder. Seek medical attention right away if any of these SEVERE side effects occur when using Leucovorin Powder:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Leucovorin Solution

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with Leucovorin Solution. Seek medical attention right away if any of these SEVERE side effects occur when using Leucovorin Solution:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Hypersensitivity

Hypersensitivity side effects, including hives, pruritus, urticaria, anaphylactoid reaction, and anaphylaxis have rarely been associated with both oral and parenteral administration of leucovorin.

Gastrointestinal

Gastrointestinal side effects associated with orally administered leucovorin include transient diarrhea. Diarrhea is usually observed when leucovorin is given with 5-fluorouracil. It typically resolves spontaneously.

Musculoskeletal

Limited data suggest the importance of folic acid antagonism as the basis for methotrexate activity in rheumatoid arthritis. More data are needed.

Musculoskeletal side effects have included increased musculoskeletal complaints and arthralgias, which have been associated with the use of low-dose orally administered leucovorin used to ameliorate side effects from methotrexate in patients with rheumatoid arthritis.

Hematologic

Hematologic side effects have included rare cases of thrombocytosis.

Respiratory

Respiratory side effects have included rare complaints of wheezing.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.