Iwilfin Side Effects

Generic name: eflornithine

Note: This document contains side effect information about eflornithine. Some dosage forms listed on this page may not apply to the brand name Iwilfin.

Applies to eflornithine: oral tablet.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• hearing problems such as ringing in your ears or hearing loss;

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may change, be delayed, or permanently discontinued if you have certain side effects.

Common side effects may include:

• fever, diarrhea, vomiting;

• ear, sinus, or skin infections;

• pneumonia;

• urinary infection (UTI);

• cold or allergy symptoms such as cough, stuffy, runny, or itchy nose, sneezing, sore throat; or

• red or swollen eyes (pinkeye).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to eflornithine: oral tablet.

General

The most frequently reported side effects included allergic rhinitis, conjunctivitis, cough, diarrhea, hearing loss, otitis media, pneumonia, pyrexia, skin infection, sinusitis, upper respiratory tract infection, urinary tract infection, and vomiting.

The most frequently reported grade 3 or 4 laboratory abnormalities included decreased hemoglobin, decreased neutrophils, increased ALT, and increased AST.^[Ref]

Dermatologic

Common (1% to 10%): Skin infection

Frequency not reported: Alopecia, rash

Gastrointestinal

Diarrhea included colitis.

Very common (10% or more): Diarrhea (15%), vomiting (11%)

Frequency not reported: Colitis

Hematologic

Common (1% to 10%): Decreased hemoglobin, decreased neutrophils, decreased platelets, decreased white blood cells

Frequency not reported: Myelosuppression

Hepatic

Common (1% to 10%): Increased ALT, increased AST

Frequency not reported: Hepatotoxicity

Musculoskeletal

Frequency not reported: Pain in extremity

Ocular

Very common (10% or more): Conjunctivitis (11%)

Other

Very common (10% or more): Otitis media (32%), pyrexia (11%)

Common (1% to 10%): Decreased glucose, decreased potassium, decreased sodium, hearing loss, increased alkaline phosphatase, increased potassium, increased glucose

Respiratory

Very common (10% or more): Allergic rhinitis (11%), cough (15%), infection (11%), pneumonia (12%), sinusitis (13%)

Common (1% to 10%): Upper respiratory tract

Genitourinary

Common (1% to 10%): Urinary tract infection

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer