Intal Side Effects
Generic name: cromolyn
Note: This document contains side effect information about cromolyn. Some of the dosage forms listed on this page may not apply to the brand name Intal.
Some side effects of Intal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cromolyn: oral capsule, oral solution
Other dosage forms:
Get emergency medical help if you have any of these signs of an allergic reaction while taking cromolyn (the active ingredient contained in Intal) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
white patches or sores inside your mouth or on your lips;
swelling of your tongue;
trouble swallowing; or
tight feeling in the chest.
Less serious side effects of cromolyn may include:
mild stomach pain, indigestion, nausea, vomiting;
diarrhea, constipation, gas;
muscle pain; or
feeling tired or irritable.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
For Healthcare Professionals
Applies to cromolyn: compounding powder, inhalation aerosol with adapter, inhalation solution, nasal spray, oral capsule, oral solution
Hypersensitivity reactions have included anaphylaxis. Hypersensitivity side effects have been reported to develop after weeks to years of use.
Respiratory side effects have included throat irritation and transient cough and bronchospasm after inhalation of cromolyn (the active ingredient contained in Intal) powder by Spinhaler. Nasal congestion has been associated with cromolyn use. Pulmonary infiltrates and pulmonary granulomatosis have been rarely reported. Wheezing and chest tightness following cromolyn use have preceded more serious allergic reactions.
Throat irritation may be relieved by drinking water before and after inhalation of cromolyn. Use of a beta-2 agonist prior to cromolyn inhalation may relieve cough and bronchospasm.
Hematologic side effects have included leukocytosis and eosinophilia.
Genitourinary side effects have included urinary burning and irritation.
Dermatologic side effects have included facial or generalized dermatitis, urticaria, and rarely, vasculitis.
Gastrointestinal side effects have been reported with inhaled cromolyn (the active ingredient contained in Intal) including nausea, vomiting, and rarely, esophagitis. Symptoms of lactose intolerance have been reported in a patient with lactase deficiency receiving cromolyn capsules by inhalation.
Hepatic side effects have included liver disease, with eosinophilic infiltrates, in association with eosinophilia.
Cardiovascular side effects have included a single case report of cardiac tamponade associated with eosinophilia.
Musculoskeletal system side effects have rarely included myositis, which involved the lower extremities resulting in pain and fatigue.
More Intal resources
- Intal Advanced Consumer (Micromedex) - Includes Dosage Information
- Intal inhalation Concise Consumer Information (Cerner Multum)
- Intal aerosol solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Intal Prescribing Information (FDA)
- cromolyn Advanced Consumer (Micromedex) - Includes Dosage Information
- Cromolyn Sodium Monograph (AHFS DI)
- Gastrocrom concentrate MedFacts Consumer Leaflet (Wolters Kluwer)
- Gastrocrom Prescribing Information (FDA)
- Gastrocrom Concise Consumer Information (Cerner Multum)
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