Hylenex Side Effects

Generic name: hyaluronidase

Note: This document contains side effect information about hyaluronidase. Some of the dosage forms listed on this page may not apply to the brand name Hylenex.

Some side effects of Hylenex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to hyaluronidase: injectable powder for injection, injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking hyaluronidase (the active ingredient contained in Hylenex) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include pain, itching, redness, or swelling where the medication was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hyaluronidase: injectable powder for injection, injectable solution

Local

Local reactions are the most common side effects. The most common side effect during hypodermoclysis is edema.

Other

Hyaluronidase (the active ingredient contained in Hylenex) increases the side effects of coadministered drugs.

Hypersensitivity

Hypersensitivity reactions have included urticaria and angioedema in less than 0.1% of patients. Anaphylactic-like reactions have rarely been reported after intravenous or retrobulbar injection.

One clinic has reported a possible increase in cases of angioedema related to the use of pharmacy-compounded hyaluronidase in cataract surgery as opposed to that seen with the use of manufactured products.

Ocular

Ocular side effects have included case reports of hypersensitivity reactions after retrobulbar injections, which manifested as increased intraorbital pressure and swelling, periorbital edema, and localized pruritus.

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