Humatin Side Effects

Generic Name: paromomycin,paromomycin sulfate

Please note - some side effects for Humatin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Humatin - for the Consumer

Humatin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Humatin:

Diarrhea; nausea; stomach cramps.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Humatin Side Effects - for the Professional

Humatin

Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.

Side Effects by Body System - for Healthcare Professionals

Gastrointestinal

Gastrointestinal side effects of paromomycin have commonly included nausea, vomiting, diarrhea, and abdominal discomfort, especially with doses greater than 3 g per day. Malabsorption of xylose and sucrose has been reported. A case of pancreatitis in an AIDS patient has been attributed to paromomycin.

A patient with AIDS developed pancreatitis after five days of therapy with paromomycin for cryptosporidiosis. Serum amylase declined progressively after paromomycin was discontinued, but became elevated after reinstitution of therapy.

Nervous system

Nervous system side effects have rarely included ototoxicity and sensorineural damage, usually in patients who also had hepatic disease. Rarely, patients may also experience headache or vertigo.

Renal

Nephrotoxicity is a consideration with the use of any aminoglycoside, however, paromomycin is poorly absorbed by the gastrointestinal tract. Accumulation of paromomycin may be problematic in patients with impaired renal function and patients treated with multiple or prolonged courses of therapy.

Hepatic

Hepatic side effects have included transient elevated aspartate transaminase (greater than 3 times ULN) and alanine transaminase (greater than 3 times ULN) in patients receiving intramuscular paromomycin during a clinical study.

Local

Local side effects have included injection site pain and swelling in patients receiving intramuscular paromomycin during a clinical study.

Other

Other side effects have included pyrexia in patients receiving intramuscular paromomycin during a clinical study.

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