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Gammagard Side Effects

Generic Name: immune globulin intravenous and subcutaneous

Note: This page contains information about the side effects of immune globulin intravenous and subcutaneous. Some of the dosage forms included on this document may not apply to the brand name Gammagard.

For the Consumer

Applies to immune globulin intravenous and subcutaneous: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking immune globulin intravenous and subcutaneous (the active ingredient contained in Gammagard) hives; wheezing, difficulty breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a blood clot in the brain--sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance;

  • signs of a blood clot in the heart or lung--chest pain, rapid heart rate, sudden cough, wheezing, rapid breathing, coughing up blood;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;

  • signs of a kidney problem--swelling, rapid weight gain, and little or no urinating;

  • liver problems--fast heart rate, dark urine, jaundice (yellowing of the skin or eyes);

  • lung problems--chest pain, trouble breathing, blue lips, pale or blue colored appearance in your fingers or toes; or

  • signs of new infection--high fever, flu symptoms, mouth sores, severe headache, neck stiffness, increased sensitivity to light, nausea and vomiting.

Common side effects may include:

  • dizziness, tired feeling;

  • sore throat;

  • joint or muscle pain;

  • diarrhea; or

  • mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to immune globulin intravenous and subcutaneous: injectable solution


Dermatologic side effects have included injection site reactions, rash, erythema, pain, swelling, ecchymosis, purpura, petechia, pruritus, urticaria, Stevens-Johnson syndrome, epidermolysis, erythema multiforme, bullous dermatitis, and hives.[Ref]


Cardiovascular side effects have included hypertension, cardiac arrest, thromboembolism, vascular collapse, and hypotension.[Ref]


Hypersensitivity side effects have included anaphylaxis.[Ref]


General side effects have included accidental injury, ear pain, and cough.[Ref]


Immunologic side effects have included have included influenza, flu syndrome, and aseptic meningitis. All U.S. immune globulin products undergo viral inactivation and/or removal; however, no method has been totally effective in removing all risk and the potential exists for the presence of unknown infectious agents.[Ref]


Hematologic side effects have included hemorrhage (all systems), epistaxis, thrombocytopenia, anemia, hemolytic anemia, pancytopenia, leucopenia, hemolysis, and positive direct antiglobulin (Coombs test).[Ref]


Musculoskeletal side effects have included arthralgia, back pain, neck pain, and rigors.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, fatigue, coma, loss of consciousness, seizures, and tremor.[Ref]


Metabolic side effects have included pyrexia, chills, and asthenia.[Ref]


Gastrointestinal side effects have included nausea, vomiting, abdominal pain, and dyspepsia.[Ref]


Respiratory side effects have included rhinitis, pharyngitis, asthma, apnea, acute respiratory distress syndrome (ARDS), transfusion related acute lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, and bronchospasm.[Ref]


Hepatic side effects have included hepatic dysfunction and transient elevations (less than 3 times the upper limit) of ALT and AST.[Ref]


1. "Product Information. Gamunex-C (immune globulin intravenous and subcutaneous)." Talecris Biotherapeutics, Research Triangle Park, NC.

Not all side effects for Gammagard may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.