FUDR Side Effects

Generic Name: floxuridine

Note: This page contains information about the side effects of floxuridine. Some of the dosage forms included on this document may not apply to the brand name FUDR.

Not all side effects for FUDR may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to floxuridine: injection powder for solution

Along with its needed effects, floxuridine (the active ingredient contained in FUDR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking floxuridine:

More common
  • Diarrhea
  • sores in mouth and on lips
  • stomach pain or cramps
Less common
  • Black, tarry stools
  • heartburn
  • nausea and vomiting
  • scaling or redness of hands or feet
  • swelling or soreness of the tongue
Rare
  • Blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on skin
  • trouble in walking
  • unusual bleeding or bruising
  • yellow eyes or skin

Some side effects of floxuridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare
  • Loss of appetite
  • skin rash or itching

This medicine sometimes causes temporary thinning of hair. After treatment with floxuridine has ended, normal hair growth should return.

For Healthcare Professionals

Applies to floxuridine: injectable powder for injection

Other

The manufacturer reports that adverse reactions to the arterial infusion of floxuridine (the active ingredient contained in FUDR) are generally related to the procedural complications of regional arterial infusion. The procedural complications of regional arterial infusion include arterial aneurysm, arterial ischemia, arterial thrombosis, embolism, fibromyositis, thrombophlebitis, hepatic necrosis, abscesses, infection at the catheter site, bleeding at the catheter site and/or a blocked, leaking, or displaced catheter.

Gastrointestinal

Gastrointestinal side effects frequently include nausea, vomiting, diarrhea, enteritis, and stomatitis. Duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain, possible intra- and extrahepatic biliary sclerosis, and acalculous cholecystitis have also been reported.

Hematologic

Hematologic side effects include anemia, leukopenia, and thrombocytopenia.

Hepatic

Hepatic side effects include elevations of alkaline phosphatase, serum transaminase, serum bilirubin, and lactic dehydrogenase.

Dermatologic

Dermatologic side effects include alopecia, dermatitis, nonspecific skin toxicity, and rash.

Cardiovascular

Cardiovascular side effects include myocardial ischemia and myocardial injury.

General

General side effects include fever, lethargy, malaise, and weakness.

Other

Laboratory abnormalities include BSP, prothrombin, total proteins, sedimentation rate and thrombocytopenia.

Nervous system

Nervous system side effects include neurotoxicity.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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