Fluonid Side Effects

Generic Name: fluocinolone topical

Note: This page contains information about the side effects of fluocinolone topical. Some of the dosage forms included on this document may not apply to the brand name Fluonid.

Not all side effects for Fluonid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to fluocinolone topical: topical application cream, topical application gel/jelly, topical application kit, topical application lotion, topical application oil, topical application ointment, topical application shampoo, topical application solution

In addition to its needed effects, some unwanted effects may be caused by fluocinolone topical (the active ingredient contained in Fluonid). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking fluocinolone topical:

More common
  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • headache
  • hoarseness
  • lightening of normal skin color
  • lightening of treated areas of dark skin
  • sore throat
  • stuffy or runny nose
  • tender, swollen glands in the neck
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
Less common
  • Acne or pimples
  • accumulation of pus
  • blistering, crusting, irritation, itching, or reddening of the skin
  • burning, itching, and pain in hairy areas, or pus at the root of the hair
  • burning and itching of the skin with pinhead-sized red blisters
  • change in hearing
  • cracked, dry, scaly skin
  • diarrhea
  • dry skin
  • earache or pain in the ear
  • ear drainage
  • flushing or redness of the skin
  • darkening of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • itchy, raised, round, smooth, skin-colored bumps found on just one area of the body
  • ooze thick white fluid
  • raised, dark red, wart-like spots on skin, especially when used on the face
  • redness or swelling in the ear
  • skin irritation
  • skin rash, encrusted, scaly and oozing
  • spots on your skin resembling a blister or pimple
  • swelling
  • swollen, red, tender area of infection
  • thickened patches of the skin
  • vomiting
Incidence not known
  • Redness and scaling around the mouth
  • thinning, weakness, or wasting away of the skin

Some of the side effects that can occur with fluocinolone topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Changes in skin color
  • shiny skin
Incidence not known
  • increased hair growth on the forehead, back, arms, and legs
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • softening of the skin

For Healthcare Professionals

Applies to fluocinolone topical: compounding powder, topical cream, topical kit, topical lotion, topical oil, topical ointment, topical shampoo, topical solution


Local side effects of fluocinolone have commonly included burning, itching, or irritation, especially when applied to denuded skin. Long-term use of topical corticosteroids has resulted in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Allergic contact dermatitis has been occasionally reported.[Ref]

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical fluocinolone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis has occasionally been reported.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.[Ref]


Endocrine side effects have included the rare suppression the hypothalamic-pituitary-adrenal axis. This suppression has been more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.[Ref]


Ocular side effects have included the development of glaucoma in a young male who applied the steroid to his eyelids for a period of several years.[Ref]


1. Tirlapur VG, Rice-Oxley JM "Facial erythema and telangiectasia with synalar cream." Br J Clin Pract 35 (1981): 275-6

2. du Vivier A, Stoughton RB "Tachyphylaxis to the action of topically applied corticosteroids." Arch Dermatol 111 (1975): 581-3

3. Burry JN "Topical drug addiction: adverse effects of fluorinated corticosteroid creams and ointments." Med J Aust 1 (1973): 393-6

4. Jablonska S, Groniowska M, Dabroswki J "Comparative evaluation of skin atrophy in man induced by topical corticoids." Br J Dermatol 100 (1979): 193-206

5. Marsden CW "Fluocinolone acetonide 0.2 per cent cream--a co-operative clinical trial." Br J Dermatol 80 (1968): 614-7

6. "Product Information. Capex (fluocinolone topical)." Galderma Laboratories Inc, Fort Worth, TX.

7. Sneddon I "Adverse effect of topical fluorinated corticosteroids in rosacea." Br Med J 1 (1969): 671-3

8. Weber G "Perioral dermatitis, an important side-effect of corticosteroids." Dermatologica 152 Suppl (1976): 161-72

9. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim

10. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.

11. Weber G "Rosacea-like dermatitis: contraindication or intolerance reaction to strong steroids." Br J Dermatol 86 (1972): 253-9

12. Cotterill JA "Perioral dermatitis." Br J Dermatol 101 (1979): 259-62

13. "Product Information. Derma-Smooth/FS (fluocinolone topical)." Hill Dermaceuticals Inc, Sanford, FL.

14. Reitamo S, Lauerma AI, Stubb S, Kayhko K, Visa K, Forstrom L "Delayed hypersensitivity to topical corticosteroids." J Am Acad Dermatol 14 (1986): 582-9

15. Pasricha JS, Gupta R "Contact sensitivity to betamethasone 17-valerate and fluocinolone acetonide." Contact Dermatitis 9 (1983): 330-1

16. Tang SC, Chan KC, Chow SP "Osteonecrosis of femoral head after topical steroid therapy." J R Coll Surg Edinb 31 (1986): 321-3

17. Cubey RB "Glaucoma following the application of corticosteroid to the skin of the eyelids." Br J Dermatol 95 (1976): 207-8

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