Entex PSE Side Effects
Generic name: guaifenesin / pseudoephedrine
Note: This document contains side effect information about guaifenesin / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Entex PSE.
Some side effects of Entex PSE may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to guaifenesin / pseudoephedrine: oral capsule, oral liquid, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release
Get emergency medical help if you have any of these signs of an allergic reaction while taking guaifenesin / pseudoephedrine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using guaifenesin and pseudoephedrine and call your doctor at once if you have:
fast, pounding, or uneven heartbeat;
severe dizziness, anxiety, or nervousness;
easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).
Other common side effects may include:
mild dizziness or headache;
feeling restless or excited;
sleep problems (insomnia);
mild nausea, vomiting, or stomach upset;
mild loss of appetite;
warmth, redness, or tingly feeling under your skin; or
skin rash or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to guaifenesin / pseudoephedrine: oral capsule, oral capsule extended release, oral liquid, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release
Cardiovascular side effects have included significant increases in heart rate. Hypertension and arrhythmias have also been problematic in susceptible patients.
Pseudoephedrine may cause vasoconstriction which generally does not produce hypertension, but may be problematic for patients with preexisting hypertension. Arrhythmias may be produced in predisposed patients. Rarely, pseudoephedrine has been reported to cause coronary artery spasm and chest pain.
Nervous system side effects of pseudoephedrine have included stimulation, resulting in tremor, anxiety, and nervousness. Insomnia has been reported in up to 30% of pseudoephedrine-treated patients. Headache has also been reported in patients receiving pseudoephedrine. Guaifenesin has occasionally caused dizziness and headache.
Gastrointestinal side effects associated with pseudoephedrine have included anorexia and gastric irritation in approximately 5% of patients. Dry mouth, nose, or throat has occurred in up to 15% of patients. Gastrointestinal upset and vomiting have been reported with higher than recommended doses of guaifenesin. Doses recommended for expectoration have rarely been associated with gastrointestinal upset.
Hypersensitivity side effects have included fixed drug eruptions secondary to pseudoephedrine.
Dermatologic side effects have included rare reports of rash.
More Entex PSE resources
- Entex PSE controlled-release capsules MedFacts Consumer Leaflet (Wolters Kluwer)
- Congestac MedFacts Consumer Leaflet (Wolters Kluwer)
- Mucinex D Prescribing Information (FDA)
- Mucinex D Consumer Overview
- Pseudovent Consumer Overview
- Robitussin Severe Congestion MedFacts Consumer Leaflet (Wolters Kluwer)
- Zephrex LA sustained-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
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